Label: DOUXO S3 PYO- ophytrium, chlorhexidine shampoo

  • NDC Code(s): 13744-154-01, 13744-154-02
  • Packager: Ceva Sante Animale
  • Category: OTC ANIMAL DRUG LABEL
  • DEA Schedule: None
  • Marketing Status: unapproved drug other

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Drug Label Information

Updated April 17, 2026

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  • SPL UNCLASSIFIED SECTION

    Soap, sulfate, paraben, phthalate, colorant and nanoparticle FREE

    Hypoallergenic fragrance, adjusted pH. Formulated and tested by veterinary dermatology experts.

  • DESCRIPTION

    ACTIVE INGREDIENT: Chlorhexidine Digluconate 3%, Ophytrium® 0.5%

    INACTIVE INGREDIENTS: Water, cocamidopropyl hydroxysultaine, decyl glucoside, capryloyl glycine, panthenol, saccharide isomerate, niacinamide, coco+vanilla hypoallergenic fragrance, PEG-200 glyceryl stearate, phenoxyethanol, citric acid, sodium hydroxide.

  • SPL UNCLASSIFIED SECTION

    PROPERTIES: Chlorhexidine provides antiseptic cleansing and Ophytrium® is a purified, natural ingredient from the S3 - Safe Skincare Selection. Ophytrium® has been carefully selected for its high tolerance and simultaneous threefold action on the skin's ecosystem:

    • Helps support the skin's physical barrier for supple, hydrated skin
    • Helps support the microbial flora for healthy skin
    • Helps soothe irritated skin
  • VETERINARY INDICATIONS

    INDICATIONS: For use on dogs or cats with bacterial or yeast skin infections that are responsive to chlorhexidine. Antiseptic shampoo that cleanses while hydrating the skin. Detangles the fur and leaves the coat soft and shiny.

  • DOSAGE & ADMINISTRATION

    DIRECTIONS: Use one pump for every 4 lbs. Double the dosage for long and/or thick fur. Wet with cool water from the neck down. First, gently massage shampoo onto the problem area. Repeat on entire body and leave on for 5-10 minutes before rinsing. Repeat if necessary. Wash hands after use. Use DOUXO® S3 PYO Mousse for a leave-on solution.

  • PRECAUTIONS

    CAUTIONS: For external use on dogs or cats only. Avoid contact with eyes. If eye contact occurs, rinse thoroughly and consult your veterinarian. If skin irritation occurs or increases, discontinue use and consult with your veterinarian. Keep out of reach of children.

  • STORAGE AND HANDLING

    Store at room temperature.

  • SPL UNCLASSIFIED SECTION

    D98410M
    18-L1-v2

    "How to use" video
    www.douxo.com

    Manufactured for Ceva Animal Health, LLC, Lenexa, KS 66215,
    800-999-0297. All trademarks are owned by
    Ceva Santé Animale S.A. or its affiliates.
    *Based on a survey of 400 veterinarians.

  • PRINCIPAL DISPLAY PANEL - 200 mL Bottle Label

    DOUXO S3®
    PYO
    Chlorhexidine 3%
    Ophytrium® 0.5%

    Shampoo

    Bacterial or yeast
    skin infections

    Antiseptic | Hydrating

    WITH
    OPHYTRIUM
    FROM
    S3
    SAFE SKINCARE SELECTION®

    For use on dogs & cats

    DOUXO® is the
    #1 topical brand
    recommended
    by VETERINARIANS*

    6.7 fl oz (200 mL)

    Ceva

    PRINCIPAL DISPLAY PANEL - 200 mL Bottle Label
  • PRINCIPAL DISPLAY PANEL - 500 mL Bottle Label

    DOUXO S3®
    PYO
    Chlorhexidine 3%
    Ophytrium® 0.5%

    Shampoo

    Bacterial or yeast
    skin infections

    Antiseptic | Hydrating

    WITH
    OPHYTRIUM
    FROM
    S3
    SAFE SKINCARE SELECTION®

    For use on dogs & cats

    DOUXO® is the
    #1 topical brand
    recommended
    by VETERINARIANS*

    16.9 fl oz (500 mL)

    Ceva

    PRINCIPAL DISPLAY PANEL - 500 mL Bottle Label
  • INGREDIENTS AND APPEARANCE
    DOUXO S3  PYO
    ophytrium, chlorhexidine shampoo
    Product Information
    Product TypeOTC ANIMAL DRUGItem Code (Source)NDC:13744-154
    Route of AdministrationTOPICAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    OPHIOPOGON JAPONICUS ROOT (UNII: 90PS6JV9GZ) (OPHIOPOGON JAPONICUS ROOT - UNII:90PS6JV9GZ) OPHIOPOGON JAPONICUS ROOT5.0 mg  in 1 mL
    CHLORHEXIDINE (UNII: R4KO0DY52L) (CHLORHEXIDINE - UNII:R4KO0DY52L) CHLORHEXIDINE30 mg  in 1 mL
    Inactive Ingredients
    Ingredient NameStrength
    COCAMIDOPROPYL HYDROXYSULTAINE (UNII: 62V75NI93W)  
    DECYL GLUCOSIDE (UNII: Z17H97EA6Y)  
    CAPRYLOYL GLYCINE (UNII: 8TY5YO42NJ)  
    SACCHARIDE ISOMERATE (UNII: W8K377W98I)  
    PEG-200 GLYCERYL STEARATE (UNII: Z8ROG2A0LZ)  
    PHENOXYETHANOL (UNII: HIE492ZZ3T)  
    CITRIC ACID MONOHYDRATE (UNII: 2968PHW8QP)  
    SODIUM HYDROXIDE (UNII: 55X04QC32I)  
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:13744-154-01200 mL in 1 BOTTLE, PLASTIC
    2NDC:13744-154-02500 mL in 1 BOTTLE, PLASTIC
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    unapproved drug other11/25/2020
    Labeler - Ceva Sante Animale (261126049)
    Registrant - Ceva Sante Animale (261126049)
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