SPL RESOURCES: Download All Indexing & REMS Files

The following indexing files are available for download as zip files.

• BILLING UNIT INDEXING FILES

  billing_unit_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 170,882
  • File size: 519.92MB
  • MD5 checksum: 5050581fc8070e3cae49c3b9c2fc9606
  • Last Modified: May 23, 2025

• BIOLOGIC OR DRUG SUBSTANCE INDEXING FILES

  biologic_or_drug_substance_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 20
  • File size: 26.51KB
  • MD5 checksum: ad4ed67ffb1987666c8cb341dd19e631
  • Last Modified: Sep 10, 2018

• FDA-INITIATED COMPLIANCE ACTION - DRUG LISTING INACTIVATION INDEXING FILES

  fda_initiated_inactive_ndcs_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 132,307
  • File size: 165.00MB
  • MD5 checksum: 679debdea22c9a3a553f6282fcbc93e6
  • Last Modified: Jun 13, 2025

• PHARMACOLOGIC CLASS INDEXING FILES

  pharmacologic_class_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 2,931
  • File size: 3.82MB
  • MD5 checksum: de5411abba1ff3c56fe0482afb5ee1f1
  • Last Modified: May 19, 2025

• PRODUCT CONCEPT INDEXING FILES

  product_concept_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 3,250
  • File size: 5.99MB
  • MD5 checksum: 36c05020fcfcde0346c04219124a7819
  • Last Modified: Apr 25, 2025

• REMS & REMS INDEXING FILES

  rems_document_and_rems_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of REMS files: 41
  • Number of REMS Indexing files: 0
  • File size: 233.12MB
  • MD5 checksum: 3cf746aef825ed87c3d6e2dd80294bde
  • Last Modified: Jun 13, 2025

• SUBSTANCE INDEXING FILES

  substance_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 108,331
  • File size: 196.56MB
  • MD5 checksum: 72ea9ce6c4d8168c8e58c225b21f9f95
  • Last Modified: Feb 7, 2022

• WARNING LETTER ALERT INDEXING FILES

  warning_letter_alert_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 10
  • File size: 16.23KB
  • MD5 checksum: 9d24df6b5510a82b0acb81673fec2742
  • Last Modified: Mar 11, 2022