SPL RESOURCES: Download All Indexing & REMS Files

The following indexing files are available for download as zip files.

• BILLING UNIT INDEXING FILES

  billing_unit_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 174,245
  • File size: 523.82MB
  • MD5 checksum: fd07f550375716df88c7a414c86166ac
  • Last Modified: Sep 18, 2025

• BIOLOGIC OR DRUG SUBSTANCE INDEXING FILES

  biologic_or_drug_substance_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 20
  • File size: 26.51KB
  • MD5 checksum: ad4ed67ffb1987666c8cb341dd19e631
  • Last Modified: Sep 10, 2018

• FDA-INITIATED COMPLIANCE ACTION - DRUG LISTING INACTIVATION INDEXING FILES

  fda_initiated_inactive_ndcs_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 134,169
  • File size: 167.34MB
  • MD5 checksum: 0c61816cb231731c33ec2f26be711017
  • Last Modified: Oct 6, 2025

• PHARMACOLOGIC CLASS INDEXING FILES

  pharmacologic_class_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 2,948
  • File size: 3.84MB
  • MD5 checksum: a5951bfd2d3d1327c0567ee19a55a0b6
  • Last Modified: Aug 25, 2025

• PRODUCT CONCEPT INDEXING FILES

  product_concept_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 3,295
  • File size: 6.08MB
  • MD5 checksum: fa59612debaa75a0dfa4006289a4a113
  • Last Modified: Aug 4, 2025

• REMS & REMS INDEXING FILES

  rems_document_and_rems_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of REMS files: 49
  • Number of REMS Indexing files: 0
  • File size: 261.47MB
  • MD5 checksum: 14928b83dee4b231af9c483a9325a0c1
  • Last Modified: Oct 6, 2025

• SUBSTANCE INDEXING FILES

  substance_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 108,331
  • File size: 196.56MB
  • MD5 checksum: 72ea9ce6c4d8168c8e58c225b21f9f95
  • Last Modified: Feb 7, 2022

• WARNING LETTER ALERT INDEXING FILES

  warning_letter_alert_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 10
  • File size: 16.23KB
  • MD5 checksum: 9d24df6b5510a82b0acb81673fec2742
  • Last Modified: Mar 11, 2022