SPL RESOURCES: Download All Indexing & REMS Files

The following indexing files are available for download as zip files.

• BILLING UNIT INDEXING FILES

  billing_unit_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 171,689
  • File size: 520.85MB
  • MD5 checksum: 1c5a759c0d8a9d5cadc381c694f1eb7d
  • Last Modified: Jun 18, 2025

• BIOLOGIC OR DRUG SUBSTANCE INDEXING FILES

  biologic_or_drug_substance_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 20
  • File size: 26.51KB
  • MD5 checksum: ad4ed67ffb1987666c8cb341dd19e631
  • Last Modified: Sep 10, 2018

• FDA-INITIATED COMPLIANCE ACTION - DRUG LISTING INACTIVATION INDEXING FILES

  fda_initiated_inactive_ndcs_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 132,431
  • File size: 165.16MB
  • MD5 checksum: 69d69ba10ddf75e946bffe15c1d42539
  • Last Modified: Jul 11, 2025

• PHARMACOLOGIC CLASS INDEXING FILES

  pharmacologic_class_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 2,936
  • File size: 3.83MB
  • MD5 checksum: 2cd6d6ec0dd653be1f09b00b8ff9ff50
  • Last Modified: Jul 4, 2025

• PRODUCT CONCEPT INDEXING FILES

  product_concept_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 3,274
  • File size: 6.04MB
  • MD5 checksum: 0a996646063692b33123e8e328039f63
  • Last Modified: Jun 30, 2025

• REMS & REMS INDEXING FILES

  rems_document_and_rems_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of REMS files: 46
  • Number of REMS Indexing files: 0
  • File size: 263.61MB
  • MD5 checksum: bc1e906163bca40c10409785cf72d089
  • Last Modified: Jul 11, 2025

• SUBSTANCE INDEXING FILES

  substance_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 108,331
  • File size: 196.56MB
  • MD5 checksum: 72ea9ce6c4d8168c8e58c225b21f9f95
  • Last Modified: Feb 7, 2022

• WARNING LETTER ALERT INDEXING FILES

  warning_letter_alert_indexing_spl_files.zip [ HTTPS / FTP ]
  • Number of files: 10
  • File size: 16.23KB
  • MD5 checksum: 9d24df6b5510a82b0acb81673fec2742
  • Last Modified: Mar 11, 2022