Label: HEAD AND SHOULDERS 2IN1 CLINICAL STRENGTH DANDRUFF DEFENSE INTENSIVE ITCH RELIEF- selenium sulfide lotion/shampoo

  • NDC Code(s): 69423-527-40
  • Packager: The Procter & Gamble Manufacturing Company
  • Category: HUMAN OTC DRUG LABEL
  • DEA Schedule: None

Drug Label Information

Updated December 31, 2025

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  • SPL UNCLASSIFIED SECTION

    Drug Facts

  • Active ingredient

    Selenium Sulfide 1%

  • Purpose

    Anti-dandruff, anti-seborrheic dermatitis

  • Uses

    helps prevent recurrence of flaking, itching, irritation, scaling and redness associated with dandruff and seborrheic dermatitis.

  • Warnings

    For external use only.

    Ask a doctor before use if you have a condition that covers a large area of the body.

    avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water.

    Stop use and ask a doctor if

    condition worsens or does not improve after regular use of this product as directed

    Keep this and all drugs out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

  • Directions

    • for best results use at least twice a week or as directed by a doctor.
    • for maximum dandruff control, use every time you shampoo.
    • shake before use.
    • wet hair, massage onto scalp, rinse, repeat if desired.
    • caution: if used on bleached, tinted, grey, or permed hair, rinse for 5 minutes.
  • Inactive ingredients

    Water, sodium lauryl sulfate, glycol distearate, sodium chloride, cocamidopropyl betaine, sodium citrate, dimethicone, sodium xylenesulfonate,menthol, fragrance, citric acid, sodium benzoate, tetrasodium EDTA, hydroxypropyl methylcellulose, mentha piperita (peppermint) oil,mentha arvensis leaf oil, red 4.

  • Questions (or comments)?

    1-800-723-9569

  • SPL UNCLASSIFIED SECTION

    Dist. by PROCTER & GAMBLE,
    CINCINNATI, OH 45202

  • PRINCIPAL DISPLAY PANEL - 400 mL BOTTLE LABEL

    head &

    shoulders ®
    selenium sulfide dandruff &

    seborrheic dermatitis shampoo

    2in1

    Clinical Strength

    Dandruff Defense

    Intensive

    Itch Relief

    Extra strength formula

    with Intense Cooling Menthol

    13.5 FL OZ (400 mL)

    HS

  • INGREDIENTS AND APPEARANCE
    HEAD AND SHOULDERS 2IN1 CLINICAL STRENGTH DANDRUFF DEFENSE INTENSIVE ITCH RELIEF 
    selenium sulfide lotion/shampoo
    Product Information
    Product TypeHUMAN OTC DRUGItem Code (Source)NDC:69423-527
    Route of AdministrationTOPICAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    SELENIUM SULFIDE (UNII: Z69D9E381Q) (SELENIUM SULFIDE - UNII:Z69D9E381Q) SELENIUM SULFIDE1 g  in 100 mL
    Inactive Ingredients
    Ingredient NameStrength
    MENTHA ARVENSIS LEAF OIL (UNII: 1AEY1M553N)  
    PEPPERMINT OIL (UNII: AV092KU4JH)  
    EDETATE DISODIUM (UNII: 7FLD91C86K)  
    MENTHOL, UNSPECIFIED FORM (UNII: L7T10EIP3A)  
    HYPROMELLOSE, UNSPECIFIED (UNII: 3NXW29V3WO)  
    WATER (UNII: 059QF0KO0R)  
    SODIUM LAURYL SULFATE (UNII: 368GB5141J)  
    GLYCOL DISTEARATE (UNII: 13W7MDN21W)  
    SODIUM CHLORIDE (UNII: 451W47IQ8X)  
    SODIUM XYLENESULFONATE (UNII: G4LZF950UR)  
    DIMETHICONE (UNII: 92RU3N3Y1O)  
    SODIUM BENZOATE (UNII: OJ245FE5EU)  
    FD&C RED NO. 4 (UNII: X3W0AM1JLX)  
    SODIUM CITRATE (UNII: 1Q73Q2JULR)  
    CITRIC ACID MONOHYDRATE (UNII: 2968PHW8QP)  
    COCAMIDOPROPYL BETAINE (UNII: 5OCF3O11KX)  
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:69423-527-40400 mL in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product11/17/202012/01/2026
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    OTC Monograph DrugM03211/17/202012/01/2026
    Labeler - The Procter & Gamble Manufacturing Company (004238200)
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