Label: MESTINON- pyridostigmine bromide solution
MESTINON- pyridostigmine bromide tablet
MESTINON- pyridostigmine bromide tablet, extended release
- NDC Code(s): 0187-3010-30, 0187-3012-20, 0187-3013-30
- Packager: Bausch Health US, LLC
- Category: HUMAN PRESCRIPTION DRUG LABEL
- DEA Schedule: None
- Marketing Status: New Drug Application
Updated April 8, 2020
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MESTINON (pyridostigmine bromide) tablets, USP is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is:
MESTINON is available in the following forms: Oral Solution containing 60 mg pyridostigmine bromide per teaspoonful in a vehicle containing 5% alcohol, glycerin, lactic acid, sodium benzoate, sorbitol, sucrose, FD&C Red No. 40, FD&C Blue No. 1, flavors and water. Tablets containing 60 mg pyridostigmine bromide; each tablet also contains lactose, silicon dioxide and stearic acid. TIMESPAN Tablets containing 180 mg pyridostigmine bromide; each tablet also contains carnauba wax, corn-derived proteins, isopropyl alcohol, magnesium stearate, silica gel, tribasic calcium phosphate and water.
MESTINON inhibits the destruction of acetylcholine by cholinesterase and thereby permits freer transmission of nerve impulses across the neuromuscular junction. Pyridostigmine is an analog of neostigmine (PROSTIGMIN™), but differs from it in certain clinically significant respects; for example, pyridostigmine is characterized by a longer duration of action and fewer gastrointestinal side effects.
Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of MESTINON may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness, and thus may be difficult to distinguish from cholinergic crisis on a symptomatic basis. Such differentiation is extremely important, since increases in doses of MESTINON or other drugs of this class in the presence of cholinergic crisis or of a refractory or “insensitive” state could have grave consequences. Osserman and Genkins1 indicate that the differential diagnosis of the two types of crisis may require the use of TENSILON™ (edrophonium chloride) as well as clinical judgment. The treatment of the two conditions obviously differs radically. Whereas the presence of myasthenic crisis suggests the need for more intensive anticholinesterase therapy, the diagnosis of cholinergic crisis, according to Osserman and Genkins1, calls for the prompt withdrawal of all drugs of this type. The immediate use of atropine in cholinergic crisis is also recommended.
Atropine may also be used to abolish or obtund gastrointestinal side effects or other muscarinic reactions; but such use, by masking signs of overdosage, can lead to inadvertent induction of cholinergic crisis.
For detailed information on the management of patients with myasthenia gravis, the physician is referred to one of the excellent reviews such as those by Osserman and Genkins2, Grob3 or Schwab.4,5
The side effects of MESTINON are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.
To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
DOSAGE AND ADMINISTRATION:
MESTINON is available in three dosage forms:
Oral Solution -
raspberry-flavored, containing 60 mg pyridostigmine bromide per teaspoonful (5 mL). This form permits accurate dosage adjustment for children and “brittle” myasthenic patients who require fractions of 60 mg doses. It is more easily swallowed, especially in the morning, by patients with bulbar involvement.
TIMESPAN Tablets -
each containing 180 mg pyridostigmine bromide. This form provides uniformly slow release, hence prolonged duration of drug action; it facilitates control of myasthenic symptoms with fewer individual doses daily. The immediate effect of a 180 mg TIMESPAN Tablet is about equal to that of a 60 mg Conventional Tablet; however, its duration of effectiveness, although varying in individual patients, averages 2½ times that of a 60 mg dose.
The size and frequency of the dosage must be adjusted to the needs of the individual patient.
Oral Solution and Conventional Tablets -
The average dose is ten 60 mg tablets or ten 5 mL teaspoonfuls daily, spaced to provide maximum relief when maximum strength is needed. In severe cases as many as 25 tablets or teaspoonfuls a day may be required, while in mild cases one to six tablets or teaspoonfuls a day may suffice.
TIMESPAN Tablets -
One to three 180 mg tablets, once or twice daily, will usually be sufficient to control symptoms; however, the needs of certain individuals may vary markedly from this average. The interval between doses should be at least 6 hours. For optimum control, it may be necessary to use the more rapidly acting regular tablets or oral solution in conjunction with TIMESPAN therapy.
NOTE: For information on a diagnostic test for myasthenia gravis, and for the evaluation and stabilization of therapy, please see product literature on TENSILON (edrophonium chloride).
Oral Solution, 60 mg pyridostigmine bromide per teaspoonful (5 mL) and 5% alcohol - bottles of 16 fluid ounces (1 pint) (NDC 0187-3012-20).
Tablets, are available as white, flat-faced tablets containing 60 mg pyridostigmine bromide in bottles of 100 (NDC 0187-3010-30). Each tablet is engraved “MESTINON 60 V” on one side and is quadrisect scored on the other.
TIMESPAN Tablets are available as light straw-colored, capsule-shaped tablets containing 180 mg pyridostigmine bromide in bottles of 30 (NDC 0187-3013-30).
Each tablet is engraved “MES V 180” on one side and is single-scored on the other.
Note: Because of the hygroscopic nature of the TIMESPAN Tablets, mottling may occur. This does not affect their efficacy.
- Osserman KE, Genkins G. Studies in myasthenia gravis: Reduction in mortality rate after crisis. JAMA. Jan 1963; 183:97-101.
- Osserman KE, Genkins G. Studies in myasthenia gravis. NY State J Med. June 1961; 61:2076-2085.
- Grob D. Myasthenia gravis. A review of pathogenesis and treatment. Arch Intern Med. Oct 1961; 108:615-638.
- Schwab RS. Management of myasthenia gravis. New Eng J Med. Mar 1963; 268:596-597.
- Schwab RS. Management of myasthenia gravis. New Eng J Med. Mar 1963; 268:717-719.
- Cronnelly R, Stanski DR, Miller RD, Sheiner LB. Pyridostigmine kinetics with and without renal function. Clin Pharmacol Ther. 1980; 28: No. 1, 78-81.
- Miller RD. Pharmacodynamics and pharmacokinetics of anticholinesterase. In: Ruegheimer E, Zindler M, ed. Anaesthesiology. (Hamburg, Germany: Congress; Sep 14-21, 1980; 222-223.) (Int Congr. No. 538), Amsterdam, Netherlands: Excerpta Medica; 1981.
- Breyer-Pfaff U, Maier U, Brinkmann AM, Schumm F. Pyridostigmine kinetics in healthy subjects and patients with myasthenia gravis. Clin Pharmacol Ther. 1985; 5:495-501.
- SPL UNCLASSIFIED SECTION
- PRINCIPAL DISPLAY PANEL - 473 mL Bottle Label
PRINCIPAL DISPLAY PANEL - 60 mg Tablets Bottle Label
contains 60 mg
Dispense in tight containers as defined in USP/NF.
IMPORTANT: These tablets are hygrosciopic. Keep in dry place with the silica gel enclosed.
Usual Dosage: See accompanying package insert.
Store at 25°C (77°F); excursions permitted to 15° to 30°C (59° to 86°F).
- PRINCIPAL DISPLAY PANEL - 180 mg Bottle Label
INGREDIENTS AND APPEARANCE
pyridostigmine bromide solution
Product Information Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:0187-3012 Route of Administration ORAL Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength pyridostigmine bromide (UNII: KVI301NA53) (pyridostigmine - UNII:19QM69HH21) pyridostigmine bromide 60 mg in 5 mL Inactive Ingredients Ingredient Name Strength alcohol (UNII: 3K9958V90M) glycerin (UNII: PDC6A3C0OX) LACTIC ACID, UNSPECIFIED FORM (UNII: 33X04XA5AT) sodium benzoate (UNII: OJ245FE5EU) sorbitol (UNII: 506T60A25R) sucrose (UNII: C151H8M554) FD&C Red No. 40 (UNII: WZB9127XOA) FD&C Blue No. 1 (UNII: H3R47K3TBD) water (UNII: 059QF0KO0R) Product Characteristics Color Score Shape Size Flavor RASPBERRY Imprint Code Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0187-3012-20 473 mL in 1 BOTTLE; Type 0: Not a Combination Product 01/25/1965 Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA015193 01/25/1965 MESTINON
pyridostigmine bromide tablet
Product Information Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:0187-3010 Route of Administration ORAL Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength pyridostigmine bromide (UNII: KVI301NA53) (pyridostigmine - UNII:19QM69HH21) pyridostigmine bromide 60 mg Inactive Ingredients Ingredient Name Strength LACTOSE, UNSPECIFIED FORM (UNII: J2B2A4N98G) silicon dioxide (UNII: ETJ7Z6XBU4) stearic acid (UNII: 4ELV7Z65AP) Product Characteristics Color WHITE Score 4 pieces Shape ROUND Size 10mm Flavor Imprint Code Mestinon;V;60 Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0187-3010-30 100 in 1 BOTTLE; Type 0: Not a Combination Product 04/06/1995 Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA009829 04/06/1955 MESTINON
pyridostigmine bromide tablet, extended release
Product Information Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:0187-3013 Route of Administration ORAL Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength pyridostigmine bromide (UNII: KVI301NA53) (pyridostigmine - UNII:19QM69HH21) pyridostigmine bromide 180 mg Inactive Ingredients Ingredient Name Strength carnauba wax (UNII: R12CBM0EIZ) magnesium stearate (UNII: 70097M6I30) silicon dioxide (UNII: ETJ7Z6XBU4) tribasic calcium phosphate (UNII: 91D9GV0Z28) WATER (UNII: 059QF0KO0R) ISOPROPYL ALCOHOL (UNII: ND2M416302) Product Characteristics Color YELLOW (light straw) Score no score Shape OVAL (capsule-shaped) Size 19mm Flavor Imprint Code MES;V;180 Contains Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:0187-3013-30 30 in 1 BOTTLE; Type 0: Not a Combination Product 01/12/1959 Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA011665 01/12/1959 Labeler - Bausch Health US, LLC (831922468) Establishment Name Address ID/FEI Business Operations Bausch Health Companies Inc. 245141858 MANUFACTURE(0187-3012, 0187-3010, 0187-3013) , LABEL(0187-3012, 0187-3010, 0187-3013) , PACK(0187-3012, 0187-3010, 0187-3013)