Label: DIPHENHYDRAMINE HCL AND ZINC ACETATE- diphenhydramine hydrochloride, zinc acetate cream

  • NDC Code(s): 45802-358-03
  • Packager: Padagis Israel Pharmaceuticals Ltd
  • Category: HUMAN OTC DRUG LABEL
  • DEA Schedule: None

Drug Label Information

Updated January 14, 2026

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  • Active ingredients

    Diphenhydramine hydrochloride 2%

    Zinc acetate 0.1%

  • Purpose

    Topical analgesic

    Skin protectant

  • Uses

    •
    temporarily relieves pain and itching associated with:
    •
    insect bites
    •
    minor burns
    •
    sunburn
    •
    minor skin irritations
    •
    minor cuts
    •
    scrapes
    •
    rashes due to poison ivy, poison oak and poison sumac
    •
    dries the oozing and weeping of poison ivy, poison oak and poison sumac
  • Warnings

    For external use only

    Do not use

    •
    on large areas of the body
    •
    with any other product containing diphenhydramine, even one taken by mouth

    Ask a doctor before use

    •
    on chicken pox
    •
    on measles

    When using this product

    •
    avoid contact with the eyes

    Stop use and ask a doctor if

    •
    condition worsens or does not improve within 7 days
    •
    symptoms persist for more than 7 days or clear up and occur again within a few days

    Keep out of reach of children.

    If swallowed, get medical help or contact a Poison Control Center right away.

  • Directions

    •
    do not use more than directed
    •
    adults and children 2 years of age and older: apply to affected area no more than 3 to 4 times daily
    •
    children under 2 years of age: ask a doctor
  • Other information

    •
    store at 20°-25°C (68°-77°F)
  • Inactive ingredients

    cetyl alcohol, diazolidinyl urea, methylparaben, PEG-2 stearate, PEG-20 stearate, propylene glycol, propylparaben, purified water

  • Questions or comments?

    1-800-719-9260

  • Principal Display Panel

    Extra Strength Itch Relief Cream

    • Relieves Itches from Insect Bites and Skin Irritations

    Compare to Extra Strength Benadryl® Cream active ingredients

    Diphenhydramine HCl & Zinc Acetate

    Extra Strength Itch Relief Cream

    Topical Analgesic • Skin Protectant

    NET WT 1 OZ (28 g)

    Padagis™

    DIPHENHYDRAMINE HCL & ZINC ACETATE CARTON IMAGE 1 OF 2
    DIPHENHYDRAMINE HCL & ZINC ACETATE CARTON IMAGE 2 OF 2
  • INGREDIENTS AND APPEARANCE
    DIPHENHYDRAMINE HCL AND ZINC ACETATE 
    diphenhydramine hydrochloride, zinc acetate cream
    Product Information
    Product TypeHUMAN OTC DRUGItem Code (Source)NDC:45802-358
    Route of AdministrationTOPICAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    DIPHENHYDRAMINE HYDROCHLORIDE (UNII: TC2D6JAD40) (DIPHENHYDRAMINE - UNII:8GTS82S83M) DIPHENHYDRAMINE HYDROCHLORIDE2 g  in 100 g
    ZINC ACETATE (UNII: FM5526K07A) (ZINC CATION - UNII:13S1S8SF37) ZINC ACETATE0.1 g  in 100 g
    Inactive Ingredients
    Ingredient NameStrength
    CETYL ALCOHOL (UNII: 936JST6JCN)  
    DIAZOLIDINYL UREA (UNII: H5RIZ3MPW4)  
    METHYLPARABEN (UNII: A2I8C7HI9T)  
    PROPYLENE GLYCOL (UNII: 6DC9Q167V3)  
    PROPYLPARABEN (UNII: Z8IX2SC1OH)  
    WATER (UNII: 059QF0KO0R)  
    PEG-20 STEARATE (UNII: NBX892EA57)  
    DIETHYLENE GLYCOL MONO- AND DIPALMITOSTEARATE (UNII: 94YQ11Y95F)  
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:45802-358-031 in 1 CARTON12/05/2005
    128 g in 1 TUBE; Type 0: Not a Combination Product
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    OTC Monograph DrugM01712/05/2005
    Labeler - Padagis Israel Pharmaceuticals Ltd (600093611)
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