Label: EFFERVESCENT ANTACID AND PAIN RELIEF- aspirin, citric acid, sodium bicarbonate tablet, effervescent

  • NDC Code(s): 37808-421-68
  • Packager: H. E. Butt Grocery Company
  • DEA Schedule: None
  • Marketing Status: OTC monograph final

DISCLAIMER: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

Drug Label Information

Updated December 19, 2022

If you are a consumer or patient please visit this version.

  • Active ingredients

    (in each effervescent tablet)

    Aspirin 325 mg (NSAID)*

    Citric acid 1000 mg

    Sodium bicarbonate (heat-treated) 1916 mg

    *Nonsteroidal anti-inflammatory drug

  • Purpose

    Aspirin 325 mg (NSAID)*. . . . . . . . . . . . . . . . . . . . . .Pain reliever

    Citric acid 1000 mg . . . . . . . . . . . . . . . . . . . . . .. . . . Antacid

    Sodium bicarbonate (heat-treated) 1916 mg . . . . . . Antacid

    *Nonsteroidal anti-inflammatory drug

  • Uses

    Uses for the temporary relief of

    ■ heartburn, acid indigestion and sour stomach when accompanied by headache or body aches and pains

    ■ upset stomach with headache from overindulgence in food or drink

    ■ pain alone (headaches or body aches and pains)

  • Warnings

    Reye’s syndrome: Children and teenagers who have or are recovering from chicken pox or flu-like symptoms should not use this product. When using this product, if changes in behavior with nausea and vomiting occur, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

    Allergy alert: Aspirin may cause a severe allergic reaction which may include: ■ hives ■ facial swelling ■ asthma (wheezing) ■ shock

    Stomach bleeding warning: This product contains a nonsteroidal anti-inflammatory drug (NSAID), which may cause severe stomach bleeding. The chance is higher if you ■ are age 60 or older ■ have had stomach ulcers or bleeding problems ■ take a blood thinning (anticoagulant) or steroid drug ■ take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others) ■ have 3 or more alcoholic drinks every day while using this product ■ take more or for a longer time than directed

  • Do not use

    Do not use ■ if you have ever had an allergic reaction to any other pain reliever/fever reducer ■ if you are allergic to aspirin ■ if overly full from food or drink. Ask a doctor if severe stomach pain occurs after taking this product.

  • Ask a doctor before use if

    Ask a doctor before use if ■ stomach bleeding warning applies to you ■ you have a history of stomach problems, such as heartburn ■ you have high blood pressure, heart disease, liver cirrhosis, or kidney disease ■ you are taking a diuretic ■ you have a sodium-restricted diet

  • Ask a doctor or pharmacist before use if you are

    Ask a doctor or pharmacist before use if you are ■ presently taking a prescription drug. Antacids may interact with certain prescription drugs. ■ taking a prescription drug for anticoagulation (thinning the blood), diabetes, gout or arthritis

  • When using this product

    When using this product do not take more than 8 tablets (adults) or 4 tablets (60 years and over) in a 24-hour period or use the maximum dosage for more than 10 days

  • Stop use and ask a doctor if

    Stop use and ask a doctor if ■ you experience any of the following signs of stomach bleeding

    ■ feel faint ■ vomit blood ■ have bloody or black stools ■ have stomach pain that does not get better

    ■ an allergic reaction occurs. Seek medical help right away.

    ■ pain lasts for more than 10 days or gets worse ■ new symptoms occur

    ■ redness or swelling is present ■ ringing in the ears or a loss of hearing occurs

  • If pregnant or breast-feeding

    If pregnant or breast-feeding, ■ ask a health professional before use. It is especially important not to use aspirin during the last 3 months of pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

  • Keep out of reach of children

    Keep out of reach of children.


    In case of overdose, get medical help or contact a Poison Control Center right away.

  • Directions

    ■ do not exceed recommended dosage

    ■ to avoid serious injury, completely dissolve tablets in 4 oz. of water before taking

    adults and children 12 years and over (up to 60 years of age): 2 tablets every 4 hours - do not exceed 8 tablets in 24 hours

    60 years and over: 2 tablets every 4 hours - do not exceed 4 tablets in 24 hours

    Take this product any time - morning, noon or night - when you need relief from heartburn, acid indigestion, sour stomach with headache or body aches and pains. Place two (2) tablets in 4 oz. of water. Dissolve tablets completely. You do not have to drink any of the residue that may be on the bottom of the glass. The medicines are in the water.

  • Other information

    each tablet contains: sodium 524 mg

    ■ store at room temperature (59-86ºF)

  • Inactive ingredients

    ■ none

  • Questions or comments?



    HEB Pain 36ct

    aspirin, citric acid, sodium bicarbonate tablet, effervescent
    Product Information
    Product TypeHUMAN OTC DRUGItem Code (Source)NDC:37808-421
    Route of AdministrationORAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    Product Characteristics
    ColorwhiteScoreno score
    FlavorImprint Code L421
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:37808-421-6818 in 1 CARTON08/10/2011
    12 in 1 POUCH; Type 0: Not a Combination Product
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    OTC monograph finalpart34308/10/2011
    Labeler - H. E. Butt Grocery Company (007924756)