Label: AMILORIDE HYDROCHLORIDE tablet

  • NDC Code(s): 57721-671-01, 57721-671-05, 57721-671-06, 57721-671-10, view more
    57721-671-16, 57721-671-30
  • Packager: WINDLAS HEALTHCARE PRIVATE LIMITED
  • Category: HUMAN PRESCRIPTION DRUG LABEL
  • DEA Schedule: None
  • Marketing Status: Abbreviated New Drug Application

Drug Label Information

Updated November 26, 2018

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  • DESCRIPTION

    Amiloride hydrochloride, an antikaliuretic-diuretic agent, is a pyrazine-carbonyl-guanidine that is unrelated chemically to other known antikaliuretic or diuretic agents. It is the salt of a moderately strong base (pKa 8.7). It is designated chemically as 3,5-diamino-6-chloro-N-(diaminomethylene) pyrazinecarboxamide monohydrochloride, dihydrate and has a molecular weight of 302.12. Its molecular formula is C 6H 8CIN 7O•HCl•2H 2O and its structural formula is:

    structure

    Amiloride hydrochloride is a pale-yellow to greenish-yellow powder. It is freely soluble in dimethylsulphoxide; slightly soluble in water, ethyl alcohol and isopropyl alcohol; sparingly soluble in methyl alcohol; practically insoluble in acetone, chloroform, diethyl ether and ethyl acetate.

    Each amiloride hydrochloride tablet intended for oral administration contains 5 mg of amiloride hydrochloride, calculated on the anhydrous basis. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, croscarmellose sodium, D&C yellow #10 aluminum lake, dibasic calcium phosphate dihydrate, FD & C yellow #6 aluminum lake, magnesium stearate, microcrystalline cellulose and povidone.

  • CLINICAL PHARMACOLOGY

    Amiloride hydrochloride is a potassium-conserving (antikaliuretic) drug that possesses weak (compared with thiazide diuretics) natriuretic, diuretic, and antihypertensive activity. These effects have been partially additive to the effects of thiazide diuretics in some clinical studies. When administered with a thiazide or loop diuretic, amiloride hydrochloride has been shown to decrease the enhanced urinary excretion of magnesium which occurs when a thiazide or loop diuretic is used alone. Amiloride hydrochloride has potassium-conserving activity in patients receiving kaliuretic-diuretic agents.

    Amiloride hydrochloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.

    Amiloride hydrochloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. This mechanism accounts in large part for the potassium sparing action of amiloride.

    Amiloride hydrochloride usually begins to act within 2 hours after an oral dose. Its effect on electrolyte excretion reaches a peak between 6 and 10 hours and lasts about 24 hours. Peak plasma levels are obtained in 3 to 4 hours and the plasma half-life varies from 6 to 9 hours. Effects on electrolytes increase with single doses of amiloride hydrochloride up to approximately 15 mg.

    Amiloride hydrochloride is not metabolized by the liver but is excreted unchanged by the kidneys. About 50 percent of a 20 mg dose of amiloride hydrochloride is excreted in the urine and 40 percent in the stool within 72 hours. Amiloride hydrochloride has little effect on glomerular filtration rate or renal blood flow. Because amiloride hydrochloride is not metabolized by the liver, drug accumulation is not anticipated in patients with hepatic dysfunction, but accumulation can occur if the hepatorenal syndrome develops.

  • INDICATIONS AND USAGE

    Amiloride hydrochloride tablets are indicated as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension to:

    a. help restore normal serum potassium levels in patients who develop hypokalemia on the kaliuretic diuretic.

    b. prevent development of hypokalemia in patients who would be exposed to particular risk if hypokalemia were to develop, e.g., digitalized patients or patients with significant cardiac arrhythmias.

    The use of potassium-conserving agents is often unnecessary in patients receiving diuretics for uncomplicated essential hypertension when such patients have a normal diet. Amiloride hydrochloride has little additive diuretic or antihypertensive effect when added to a thiazide diuretic.

    Amiloride hydrochloride tablets should rarely be used alone. It has weak (compared with thiazides) diuretic and antihypertensive effects. Used as single agents, potassium sparing diuretics, including amiloride hydrochloride, result in an increased risk of hyperkalemia (approximately 10% with amiloride). Amiloride hydrochloride tablets should be used alone only when persistent hypokalemia has been documented and only with careful titration of the dose and close monitoring of serum electrolytes.

  • CONTRAINDICATIONS

    Hyperkalemia

    Amiloride hydrochloride tablets should not be used in the presence of elevated serum potassium levels (greater than 5.5 mEq per liter).

    Antikaliuretic Therapy or Potassium Supplementation

    Amiloride hydrochloride should not be given to patients receiving other potassium-conserving agents, such as spironolactone or triamterene. Potassium supplementation in the form of medication, potassium-containing salt substitutes or a potassium-rich diet should not be used with amiloride hydrochloride except in severe and/or refractory cases of hypokalemia. Such concomitant therapy can be associated with rapid increases in serum potassium levels. If potassium supplementation is used, careful monitoring of the serum potassium level is necessary.

    Impaired Renal Function

    Anuria, acute or chronic renal insufficiency, and evidence of diabetic nephropathy are contraindications to the use of amiloride hydrochloride. Patients with evidence of renal functional impairment (blood urea nitrogen [BUN] levels over 30 mg per 100 mL or serum creatinine levels over 1.5 mg per 100 mL) or diabetes mellitus should not receive the drug without careful, frequent and continuing monitoring of serum electrolytes, creatinine, and BUN levels. Potassium retention associated with the use of an antikaliuretic agent is accentuated in the presence of renal impairment and may result in the rapid development of hyperkalemia.

    Hypersensitivity

    Amiloride hydrochloride is contraindicated in patients who are hypersensitive to this product.

  • WARNINGS

  • BOXED WARNING (What is this?)

    Hyperkalemia

    Like other potassium-conserving agents, amiloride may cause hyperkalemia (serum potassium levels greater than 5.5 mEq per liter) which, if uncorrected, is potentially fatal. Hyperkalemia occurs commonly (about 10%) when amiloride is used without a kaliuretic diuretic. This incidence is greater in patients with renal impairment, diabetes mellitus (with or without recognized renal insufficiency), and in the elderly. When amiloride hydrochloride is used concomitantly with a thiazide diuretic in patients without these complications, the risk of hyperkalemia is reduced to about 1 to 2 percent. It is thus essential to monitor serum potassium levels carefully in any patient receiving amiloride, particularly when it is first introduced, at the time of diuretic dosage adjustments, and during any illness that could affect renal function.

  • SPL UNCLASSIFIED SECTION

    The risk of hyperkalemia may be increased when potassium-conserving agents, including amiloride hydrochloride, are administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus. (See PRECAUTIONS, Drug Interactions.) Warning signs or symptoms of hyperkalemia include paresthesias, muscular weakness, fatigue, flaccid paralysis of the extremities, bradycardia, shock, and ECG abnormalities. Monitoring of the serum potassium level is essential because mild hyperkalemia is not usually associated with an abnormal ECG.

    When abnormal, the ECG in hyperkalemia is characterized primarily by tall, peaked T waves or elevations from previous tracings. There may also be lowering of the R wave and increased depth of the S wave, widening and even disappearance of the P wave, progressive widening of the QRS complex, prolongation of the PR interval, and ST depression.

    Treatment of hyperkalemia:

    If hyperkalemia occurs in patients taking amiloride hydrochloride, the drug should be discontinued immediately. If the serum potassium level exceeds 6.5 mEq per liter, active measures should be taken to reduce it. Such measures include the intravenous administration of sodium bicarbonate solution or oral or parenteral glucose with a rapid-acting insulin preparation. If needed, a cation exchange resin such as sodium polystyrene sulfonate may be given orally or by enema. Patients with persistent hyperkalemia may require dialysis.

    Diabetes Mellitus

    In diabetic patients, hyperkalemia has been reported with the use of all potassium-conserving diuretics, including amiloride hydrochloride, even in patients without evidence of diabetic nephropathy. Therefore, amiloride hydrochloride should be avoided, if possible, in diabetic patients and, if it is used, serum electrolytes and renal function must be monitored frequently.

    Amiloride hydrochloride should be discontinued at least three days before glucose tolerance testing.

    Metabolic or Respiratory Acidosis

    Antikaliuretic therapy should be instituted only with caution in severely ill patients in whom respiratory or metabolic acidosis may occur, such as patients with cardiopulmonary disease or poorly controlled diabetes. If amiloride hydrochloride is given to these patients, frequent monitoring of acid-base balance is necessary. Shifts in acid-base balance alter the ratio of extracellular/intracellular potassium, and the development of acidosis may be associated with rapid increases in serum potassium levels.

  • PRECAUTIONS

    General

    Electrolyte Imbalance and BUN Increases

    Hyponatremia and hypochloremia may occur when amiloride hydrochloride is used with other diuretics and increases in BUN levels have been reported. These increases usually have accompanied vigorous fluid elimination, especially when diuretic therapy was used in seriously ill patients, such as those who had hepatic cirrhosis with ascites and metabolic alkalosis, or those with resistant edema. Therefore, when amiloride hydrochloride is given with other diuretics to such patients, careful monitoring of serum electrolytes and BUN levels is important. In patients with pre-existing severe liver disease, hepatic encephalopathy, manifested by tremors, confusion, and coma, and increased jaundice, have been reported in association with diuretics, including amiloride hydrochloride.

    Drug Interactions

    When amiloride hydrochloride is administered concomitantly with an angiotensin-converting enzyme inhibitor, an angiotensin II receptor antagonist, cyclosporine or tacrolimus, the risk of hyperkalemia may be increased. Therefore, if concomitant use of these agents is indicated because of demonstrated hypokalemia, they should be used with caution and with frequent monitoring of serum potassium. (See WARNINGS).

    Lithium generally should not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity. Read circulars for lithium preparations before use of such concomitant therapy.

    In some patients, the administration of a non-steroidal anti-inflammatory agent can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium-sparing and thiazide diuretics. Therefore, when amiloride hydrochloride and non-steroidal anti-inflammatory agents are used concomitantly, the patient should be observed closely to determine if the desired effect of the diuretic is obtained. Since indomethacin and potassium-sparing diuretics, including amiloride hydrochloride, may each be associated with increased serum potassium levels, the potential effects on potassium kinetics and renal function should be considered when these agents are administered concurrently.

    Carcinogenesis, Mutagenesis, Impairment of Fertility

    There was no evidence of a tumorigenic effect when amiloride hydrochloride was administered for 92 weeks to mice at doses up to 10 mg/kg/day (25 times the maximum daily human dose). Amiloride hydrochloride has also been administered for 104 weeks to male and female rats at doses up to 6 and 8 mg/kg/day (15 and 20 times the maximum daily dose for humans, respectively) and showed no evidence of carcinogenicity.

    Amiloride hydrochloride was devoid of mutagenic activity in various strains of Salmonella typhimurium with or without a mammalian liver microsomal activation system (Ames test).

    Pregnancy

    Pregnancy Category B.

    Teratogenicity studies with amiloride hydrochloride in rabbits and mice given 20 and 25 times the maximum human dose, respectively, revealed no evidence of harm to the fetus, although studies showed that the drug crossed the placenta in modest amounts. Reproduction studies in rats at 20 times the expected maximum daily dose for humans showed no evidence of impaired fertility. At approximately 5 or more times the expected maximum daily dose for humans, some toxicity was seen in adult rats and rabbits and a decrease in rat pup growth and survival occurred.

    There are, however, no adequate and well-controlled studies in pregnant women. Because animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed.

    Nursing Mothers

    Studies in rats have shown that amiloride hydrochloride is excreted in milk in concentrations higher than those found in blood, but it is not known whether amiloride is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from amiloride hydrochloride, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

    Pediatric Use

    Safety and effectiveness in pediatric patients have not been established.

    Geriatric Use

    Clinical studies of amiloride hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

    This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. (See CONTRAINDICATIONS, Impaired Renal Function.)

  • ADVERSE REACTIONS

    Amiloride hydrochloride is usually well tolerated and, except for hyperkalemia (serum potassium levels greater than 5.5 mEq per liter – see WARNINGS), significant adverse effects have been reported infrequently. Minor adverse reactions were reported relatively frequently (about 20%) but the relationship of many of the reports to amiloride hydrochloride is uncertain and the overall frequency was similar in hydrochlorothiazide treated groups. Nausea/anorexia, abdominal pain, flatulence, and mild skin rash have been reported and probably are related to amiloride. Other adverse experiences that have been reported with amiloride are generally those known to be associated with diuresis, or with the underlying disease being treated.

    The adverse reactions for amiloride hydrochloride listed in the following table have been arranged into two groups: (1) incidence greater than one percent; and (2) incidence one percent or less. The incidence for group (1) was determined from clinical studies conducted in the United States (837 patients treated with amiloride hydrochloride). The adverse effects listed in group (2) include reports from the same clinical studies and voluntary reports since marketing. The probability of a causal relationship exists between amiloride hydrochloride and these adverse reactions, some of which have been reported only rarely.

    Incidence > 1%

    Incidence 1%

    Body as a Whole

    Headache*

    Back pain

    Weakness

    Chest pain

    Fatigability

    Neck/shoulder ache

    Pain, extremities

    Cardiovascular

    None

    Angina pectoris

    Orthostatic hypotension

    Arrhythmia

    Palpitation

    Digestive

    Nausea/anorexia*

    Jaundice

    Diarrhea*

    GI bleeding

    Vomiting*

    Abdominal fullness

    Abdominal pain

    GI disturbance

    Gas pain

    Thirst

    Appetite changes

    Heartburn

    Constipation

    Flatulence

    Dyspepsia

    Metabolic Elevated serum potassium levels (>5.5 mEq per liter)**

    None

    Skin

    None

    Skin rash

    Itching

    Dryness of mouth

    Pruritus

    Alopecia

    Musculoskeletal

    Muscle cramps

    Joint pain

    Leg ache

    Nervous

    Dizziness

    Paresthesia

    Encephalopathy

    Tremors

    Vertigo

    Psychiatric

    None

    Nervousness

    Mental confusion

    Insomnia

    Decreased libido

    Depression

    Somnolence

    Respiratory

    Cough

    Shortness of Breath

    Dyspnea

    Special Senses

    None

    Visual disturbances

    Nasal congestion

    Tinnitus

    Increased intraocular pressure

    Urogenital

    Impotence

    Polyuria

    Dysuria

    Urinary frequency

    Bladder spasms

    Gynecomastia

    *Reactions occurring in 3% to 8% of patients treated with amiloride hydrochloride.

    (Those reactions occurring in less than 3% of the patients are unmarked.)

    **See WARNINGS.

    Causal Relationship Unknown

    Other reactions have been reported but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, that possibility cannot be excluded. Therefore, these observations are listed to serve as alerting information to physicians.

    Activation of probable pre-existing peptic ulcer

    Aplastic anemia

    Neutropenia

    Abnormal liver function

  • OVERDOSAGE

    No data are available in regard to overdosage in humans.

    The oral LD 50 of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. It is not known whether the drug is dialyzable.

    The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance. These can be treated by established procedures. Therapy with amiloride hydrochloride should be discontinued and the patient observed closely. There is no specific antidote. Emesis should be induced or gastric lavage performed. Treatment is symptomatic and supportive. If hyperkalemia occurs, active measures should be taken to reduce the serum potassium levels.

  • DOSAGE AND ADMINISTRATION

    Amiloride hydrochloride should be administered with food.

    Amiloride hydrochloride, one 5 mg tablet daily, should be added to the usual antihypertensive or diuretic dosage of a kaliuretic diuretic. The dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets of amiloride hydrochloride daily usually are not needed, and there is little controlled experience with such doses. If persistent hypokalemia is documented with 10 mg, the dose can be increased to 15 mg, then 20 mg, with careful monitoring of electrolytes.

    In treating patients with congestive heart failure after an initial diuresis has been achieved, potassium loss may also decrease and the need for amiloride hydrochloride should be re-evaluated. Dosage adjustment may be necessary. Maintenance therapy may be on an intermittent basis.

    If it is necessary to use amiloride hydrochloride alone (see INDICATIONS), the starting dosage should be one 5 mg tablet daily. This dosage may be increased to 10 mg per day, if necessary. More than two 5 mg tablets usually are not needed, and there is little controlled experience with such doses. If persistent hypokalemia is documented with 10 mg, the dose can be increased to 15 mg, then 20 mg, with careful monitoring of electrolytes.

  • HOW SUPPLIED

    Amiloride Hydrochloride Tablets USP, 5 mg are yellow colored, may be spotted, round shaped, biconvex, uncoated tablets, debossed with "671" on one side and plain on the other side and are supplied as follows:

    NDC 57721-671-06 in bottle of 30 tablets

    NDC 57721-671-16 in bottle of 90 tablets

    NDC 57721-671-01 in bottle of 100 tablets

    NDC 57721-671-05 in bottle of 500 tablets

    NDC 57721-671-10 in bottle of 1000 tablets

    NDC 57721-671-30 in unit-dose blister cartons of 100 (10 X 10) unit-dose tablets

    Storage

    Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].

    Dispense in a tight container (USP).

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

    Manufactured by:

    Cadila Healthcare Ltd.

    Baddi, India

    Distributed by:

    Windlas Inc.
    325 Sharon Park Drive
    PMB # 202
    Menlo Park, CA 94025

    Rev.: 12/17

  • PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

    NDC 57721-671-01 in bottle of 100 tablets

    Amiloride Hydrochloride Tablets, USP

    5 mg

    Rx only

    100 Tablets

    Windlas Healthcare Pvt. Ltd.

    bottle-label

  • INGREDIENTS AND APPEARANCE
    AMILORIDE HYDROCHLORIDE 
    amiloride hydrochloride tablet
    Product Information
    Product TypeHUMAN PRESCRIPTION DRUGItem Code (Source)NDC:57721-671
    Route of AdministrationORAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    AMILORIDE HYDROCHLORIDE (UNII: FZJ37245UC) (AMILORIDE - UNII:7DZO8EB0Z3) AMILORIDE HYDROCHLORIDE ANHYDROUS5 mg
    Inactive Ingredients
    Ingredient NameStrength
    MICROCRYSTALLINE CELLULOSE (UNII: OP1R32D61U)  
    SILICON DIOXIDE (UNII: ETJ7Z6XBU4)  
    CROSCARMELLOSE SODIUM (UNII: M28OL1HH48)  
    D&C YELLOW NO. 10 (UNII: 35SW5USQ3G)  
    DIBASIC CALCIUM PHOSPHATE DIHYDRATE (UNII: O7TSZ97GEP)  
    FD&C YELLOW NO. 6 (UNII: H77VEI93A8)  
    MAGNESIUM STEARATE (UNII: 70097M6I30)  
    POVIDONE K30 (UNII: U725QWY32X)  
    Product Characteristics
    ColoryellowScoreno score
    ShapeROUNDSize7mm
    FlavorImprint Code 671
    Contains    
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:57721-671-0630 in 1 BOTTLE; Type 0: Not a Combination Product10/14/2019
    2NDC:57721-671-1690 in 1 BOTTLE; Type 0: Not a Combination Product10/14/2019
    3NDC:57721-671-01100 in 1 BOTTLE; Type 0: Not a Combination Product10/14/2019
    4NDC:57721-671-05500 in 1 BOTTLE; Type 0: Not a Combination Product10/14/2019
    5NDC:57721-671-101000 in 1 BOTTLE; Type 0: Not a Combination Product10/14/2019
    6NDC:57721-671-3010 in 1 CARTON10/14/2019
    610 in 1 BLISTER PACK; Type 0: Not a Combination Product
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    ANDAANDA20418010/14/2019
    Labeler - WINDLAS HEALTHCARE PRIVATE LIMITED (862102160)
    Registrant - USpharma Windlas LLC (081039234)
    Establishment
    NameAddressID/FEIBusiness Operations
    Cadila Healthcare Limited677605858analysis(57721-671) , manufacture(57721-671)