Label: AMINOCAPROIC ACID- aminocaproic acid tablet

  • NDC Code(s): 69680-115-00, 69680-115-30, 69680-116-00, 69680-116-30
  • Packager: Vitruvias Therapeutics
  • Category: HUMAN PRESCRIPTION DRUG LABEL
  • DEA Schedule: None
  • Marketing Status: Abbreviated New Drug Application

Drug Label Information

Updated December 3, 2018

If you are a consumer or patient please visit this version.

  • SPL UNCLASSIFIED SECTION

    Rx only

    Close
  • DESCRIPTION

    Aminocaproic Acid Tablets (aminocaproic acid} is 6-aminohexanoic acid, which acts as an inhibitor of fibrinolysis. Its chemical structure is:

    Chemical Structure

    C16H13NO2    M.W. 131.17

    Aminocaproic acid is soluble in water, acid, and alkaline solutions; it is sparingly soluble in methanol and practically insoluble in chloroform.

    Each Aminocaproic Acid Tablets, for oral administration contains 500 mg or 1000 mg of aminocaproic acid and the following inactive ingredients: povidone, crospovidone, stearic acid, and magnesium stearate.

    Close
  • CLINICAL PHARMACOLOGY

    The fibrinolysis-inhibitory effects of Aminocaproic Acid Tablets appear to be exerted principally via inhibition of plasminogen activators and to a lesser degree through antiplasmin activity.

    In adults, oral absorption appears to be a zero-order process with an absorption rate of 5.2 g/hr. The mean lag time in absorption is 10 minutes. After a single oral dose of 5 g, absorption was complete (F=1 ). Mean ± SD peak plasma concentrations (164 ± 28 mcg/ml) were reached within 1.2 ± 0.45 hours.

    After oral administration, the apparent volume of distribution was estimated to be 23.1 ± 6.6 L (mean ± SD). Correspondingly, the volume of distribution after intravenous administration has been reported to be 30.0 ± 8.2 L. After prolonged administration, Aminocaproic Acid Tablets has been found to distribute throughout extravascular and intravascular compartments of the body, penetrating human red blood cells as well as other tissue cells.

    Renal excretion is the primary route of elimination. Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11 % of the dose appears as the metabolite adipic acid. Renal clearance (116 mL/min) approximates endogenous creatinine clearance. The total body clearance is 169 ml/min. The terminal elimination half-life for Aminocaproic Acid Tablets is approximately 2 hours.

    Close
  • INDICATIONS AND USAGE

    Aminocaproic Acid Tablets is useful in enhancing hemostasis when fibrinolysis contributes to bleeding. In life-threatening situations, transfusion of appropriate blood products and other emergency measures may be required.

    Fibrinolytic bleeding may frequently be associated with surgical complications following heart surgery (with or without cardiac bypass procedures) and portacaval shunt; hematological disorders such as amegakaryocytic thrombocytopenia (accompanying aplastic anemia); acute and life-threatening abruptio placentae; hepatic cirrhosis; and neoplastic disease such as carcinoma of the prostate, lung, stomach, and cervix.

    Urinary fibrinolysis, usually a normal physiological phenomenon, may contribute to excessive urinary tract fibrinolytic bleeding associated with surgical hematuria (following prostatectomy and nephrectomy) or nonsurgical hematuria (accompanying polycystic or neoplastic diseases of the genitourinary system). (See WARNINGS.)

    Close
  • CONTRAINDICATIONS

    Aminocaproic Acid Tablets should not be used when there is evidence of an active intravascular clotting process.

    When there is uncertainty as to whether the cause of bleeding is primary fibrinolysis or disseminated intravascular coagulation (DIC), this distinction must be made before administering Aminocaproic Acid Tablets.

    The following tests can be applied to differentiate the two conditions:

    • Platelet count is usually decreased in DIC but normal in primary fibrinolysis.
    • Protamine paracoagulation test is positive in DIC; a precipitate forms when protamine sulfate is dropped into citrated plasma. The test is negative in the presence of primary fibrinolysis.
    • The euglobulin clot lysis test is abnormal in primary fibrinolysis but normal in DIC.

    Aminocaproic Acid Tablets must not be used in the presence of DIC without concomitant heparin.

    Close
  • WARNINGS

    In patients with upper urinary tract bleeding, Aminocaproic Acid Tablets administration have been known to cause intrarenal obstruction in the form of glomerular capillary thrombosis or clots in the renal pelvis and ureters. For this reason, Aminocaproic Acid Tablets should not be used in hematuria of upper urinary tract origin, unless the possible benefits outweigh the risk.

    Subendocardial hemorrhages have been observed in dogs given intravenous infusions of 0.2 times the maximum human therapeutic dose of AminocaproicAcid Tablets and in monkeys given 8 times the maximum human therapeutic dose of AminocaproicAcid Tablets.

    Fatty degeneration of the myocardium has been reported in dogs given intravenous doses of Aminocaproic Acid Tablets at 0.8 to 3.3 times the maximum human therapeutic dose and in monkeys given intravenous doses of Aminocaproic Acid Tablets at 6 times the maximum human therapeutic dose.

    Rarely, skeletal muscle weakness with necrosis of muscle fibers has been reported following prolonged administration.

    Clinical presentation may range from mild myalgias with weakness and fatigue to a severe proximal myopathy with rhabdomyolysis, myoglobinuria, and acute renal failure. Muscle enzymes, especially creatine phosphokinase (CPK) are elevated. CPK levels should be monitored in patients on long-term therapy. Aminocaproic Acid Tablets administration should be stopped if a rise in CPK is noted. Resolution follows discontinuation of Aminocaproic Acid Tablets; however, the syndrome may recur if Aminocaproic Acid Tablets is restarted.

    The possibility of cardiac muscle damage should also be considered when skeletal myopathy occurs. One case of cardiac and hepatic lesions observed in man has been reported. The patient received 2 g of aminocaproic acid every 6 hours for a total dose of 26 g. Death was due to continued cerebrovascular hemorrhage. Necrotic changes in the heart and liver were noted at autopsy.

    Close
  • PRECAUTIONS

    General

    Aminocaproic Acid Tablets inhibits both the action of plasminogen activators and to a lesser degree, plasmin activity. The drug should NOT be administered without a definite diagnosis and/or laboratory finding indicative of hyperfibrinolysis (hyperplasminemia)1.

    Inhibition of fibrinolysis by aminocaproic acid may theoretically result in clotting or thrombosis. However, there is no definite evidence that administration of aminocaproic acid has been responsible for the few reported cases of intravascular clotting which followed this treatment. Rather, it appears that such intravascular clotting was most likely due to the patient's preexisting clinical condition, e.g., the presence of DIC. It has been postulated that extravascular clots formed in vivo may not undergo spontaneous lysis as do normal clots.

    Reports have appeared in the literature of an increased incidence of certain neurological deficits such as hydrocephalus, cerebral ischemia, or cerebral vasospasm associated with the use of antifibrinolytic agents in the treatment of subarachnoid hemorrhage (SAH). All of these events have also been described as part of the natural course of SAH, or as a consequence of diagnostic procedures such as angiography. Drug relatedness remains unclear.

    Aminocaproic acid should not be administered with Factor IX Complex concentrates or Anti-Inhibitor Coagulant concentrates, as the risk of thrombosis may be increased.

    Laboratory Tests

    The use of Aminocaproic Acid Tablets should be accompanied by tests designed to determine the amount of fibrinolysis present. There are presently available: (a) general tests such as those for the determination of the lysis of a clot of blood or plasma; and (b) more specific tests for the study of various phases of the fibrinolytic mechanisms. These latter tests include both semiquantitative and quantitative techniques for the determination of profibrinolysin, fibrinolysin, and antifibrinolysin.

    Drug Laboratory Test Interactions

    Prolongation of the template bleeding time has been reported during continuous intravenous infusion of Aminocaproic Acid Tablets at dosages exceeding 24 g/day. Platelet function studies in these patients have not demonstrated any significant platelet dysfunction. However, in vitro studies have shown that at high concentrations (7.4 mMol/L or 0.97 mg/ml and greater) aminocaproic acid inhibits ADP and collagen-induced platelet aggregation, the release of ATP and serotonin, and the binding of fibrinogen to the platelets in a concentration-response manner. Following a 10 g bolus of Aminocaproic Acid Tablets, transient peak plasma concentrations of 4.6 mMol/L or 0.60 mg/ml have been obtained. The concentration of Aminocaproic Acid Tablets necessary to maintain inhibition of fibrinolysis is 0.99 mMol/L or 0.13 mg/ml. Administration of a 5 g bolus followed by 1 to 1.25 g/hr should achieve and sustain plasma levels of 0.13 mg/ml. Thus, concentrations which have been obtained in vivo clinically in patients with normal renal function are considerably lower than the in vitro concentrations found to induce abnormalities in platelet function tests. However, higher plasma concentrations of Aminocaproic Acid Tablets may occur in patients with severe renal failure.

    Carcinogenesis, Mutagenesis, Impairment of Fertility

    Long-term studies in animals to evaluate the carcinogenic potential of Aminocaproic Acid Tablets and studies to evaluate its mutagenic potential have not been conducted. Dietary administration of an equivalent of the maximum human therapeutic dose of Aminocaproic Acid Tablets to rats of both sexes impaired fertility as evidenced by decreased implantations, litter sizes and number of pups born.

    Pregnancy

    Pregnancy Category C

    Animal reproduction studies have not been conducted with Aminocaproic Acid Tablets. It is also not known whether Aminocaproic Acid Tablets can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Aminocaproic Acid Tablets should be given to a pregnant woman only if clearly needed.

    Nursing Mothers

    It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Aminocaproic Acid Tablets is administered to a nursing woman.

    Pediatric Use

    Safety and effectiveness in pediatric patients have not been established.

    Close
  • ADVERSE REACTIONS

    Aminocaproic Acid Tablets is generally well tolerated. The following adverse experiences have been reported:

    General: Edema, headache, malaise.

    Hypersensitivity Reactions: Allergic and anaphylactoid reactions, anaphylaxis.

    Cardiovascular: Bradycardia, hypotension, peripheral ischemia, thrombosis.

    Gastrointestinal: Abdominal pain, diarrhea, nausea, vomiting.

    Hematologic: Agranulocytosis, coagulation disorder, leukopenia, thrombocytopenia.

    Musculoskeletal: CPK increased, muscle weakness, myalgia, myopathy (see WARNINGS), myositis, rhabdomyolysis.

    Neurologic: Confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.

    Respiratory: Dyspnea, nasal congestion, pulmonary embolism.

    Skin: Pruritis, rash.

    Special Senses: Tinnitus, vision decreased, watery eyes.

    Urogenital: BUN increased, renal failure. There have been some reports of dry ejaculation during the period of Aminocaproic Acid Tablets treatment. These have been reported to date only in hemophilia patients who received the drug after undergoing dental surgical procedures. However, this symptom resolved in all patients within 24 to 48 hours of completion of therapy.

    Close
  • OVERDOSAGE

    A few cases of acute overdosage with Aminocaproic Acid Tablets administered intravenously have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. One patient with a history of brain tumor and seizures experienced seizures after receiving an 8 gram bolus injection of Aminocaproic Acid Tablets. The single dose of Aminocaproic Acid Tablets causing symptoms of overdosage or considered to be life-threatening is unknown. Patients have tolerated doses as high as 100 grams while acute renal failure has been reported following a dose of 12 grams.

    The intravenous and oral LD50 of Aminocaproic Acid Tablets were 3.0 and 12.0 g/kg, respectively, in the mouse and 3.2 and 16.4 g/kg, respectively, in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog. On intravenous administration, tonic-clonic convulsions were observed in dogs and mice.

    No treatment for overdosage is known, although evidence exists that Aminocaproic Acid Tablets is removed by hemodialysis and may be removed by peritoneal dialysis. Pharmacokinetic studies have shown that total body clearance of Aminocaproic Acid Tablets is markedly decreased in patients with severe renal failure.

    Close
  • DOSAGE AND ADMINISTRATION

    An identical dosage regimen may be followed by administering AminocaproicAcid Tablets as follows:

    For the treatment of acute bleeding syndromes due to elevated fibrinolytic activity, it is suggested that 5 Aminocaproic Acid Tablets, 1000 mg or 10 Aminocaproic Acid Tablets, 500 mg (5 g) be administered during the first hour of treatment, followed by a continuing rate of 1 Aminocaproic Acid Tablets, 1000 mg or 2 Aminocaproic Acid Tablets, 500 mg (1 g) per hour. This method of treatment would ordinarily be continued for about 8 hours or until the bleeding situation has been controlled.

    Close
  • HOW SUPPLIED

    Aminocaproic Acid Tablets, USP 500 mg

    Each round, white to off-white tablet, bisect debossed with logo "010" on top and bottom of the scored line on one side and the other side is blank, contains 500 mg of aminocaproic acid.

    Bottle of 30 – NDC 69680-115-30
    Bottle of 100 – NDC 69680-115-00

    Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]; Dispense in Tight Containers.

    Aminocaproic Acid Tablets, USP 1000 mg

    Each oblong, white to off-white tablet, bisect debossed with logo "009" on left and right of the scored line on one side and the other side is blank, contains 1000 mg of aminocaproic acid.

    Bottle of 30 – NDC 69680-116-30
    Bottle of 100 – NDC 69680-116-00

    Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]; Dispense in Tight Containers.

    Close
  • REFERENCE

    1Stefanini M, Dameshek W: The Hemorrhagic Disorders, Ed.

    2, New York, Grune and Stratton; 1962:510-514.

    Close
  • SPL UNCLASSIFIED SECTION

    Mfg. By
    Lotus Pharmaceutical Co., Ltd.
    Nantou County 540, Taiwan

    Distributed by
    Vitruvias Therapeutics
    Auburn, AL 36830 USA

    To request medical information or to report SUSPECTED ADVERSE REACTIONS, contact Vitruvias Therapeutics at 1-844-451-5944 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

    I114 0518R0

    Close
  • PRINCIPAL DISPLAY PANEL - 500 mg Tablet Bottle Label

    NDC 69680-115-30

    Rx only

    Aminocaproic Acid
    Tablets USP, 500mg

    30 Tablets

    VITRUVIAS
    therapeutics

    PRINCIPAL DISPLAY PANEL - 500 mg Tablet Bottle Label
    Close
  • PRINCIPAL DISPLAY PANEL - 1000 mg Tablet Bottle Label

    NDC 69680-116-30

    Rx only

    Aminocaproic Acid
    Tablets USP, 1000mg

    30 Tablets

    VITRUVIAS
    therapeutics

    PRINCIPAL DISPLAY PANEL - 1000 mg Tablet Bottle Label
    Close
  • INGREDIENTS AND APPEARANCE
    AMINOCAPROIC ACID 
    aminocaproic acid tablet
    Product Information
    Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:69680-115
    Route of Administration ORAL
    Active Ingredient/Active Moiety
    Ingredient Name Basis of Strength Strength
    Aminocaproic Acid (UNII: U6F3787206) (Aminocaproic Acid - UNII:U6F3787206) Aminocaproic Acid 500 mg
    Inactive Ingredients
    Ingredient Name Strength
    POVIDONE K30 (UNII: U725QWY32X)  
    CROSPOVIDONE, UNSPECIFIED (UNII: 2S7830E561)  
    Stearic Acid (UNII: 4ELV7Z65AP)  
    Magnesium Stearate (UNII: 70097M6I30)  
    Product Characteristics
    Color WHITE Score 2 pieces
    Shape ROUND Size 13mm
    Flavor Imprint Code 010;010
    Contains     
    Packaging
    # Item Code Package Description Marketing Start Date Marketing End Date
    1 NDC:69680-115-30 30 in 1 BOTTLE; Type 0: Not a Combination Product 12/03/2018
    2 NDC:69680-115-00 100 in 1 BOTTLE; Type 0: Not a Combination Product 12/03/2018
    Marketing Information
    Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
    ANDA ANDA209060 12/03/2018
    AMINOCAPROIC ACID 
    aminocaproic acid tablet
    Product Information
    Product Type HUMAN PRESCRIPTION DRUG Item Code (Source) NDC:69680-116
    Route of Administration ORAL
    Active Ingredient/Active Moiety
    Ingredient Name Basis of Strength Strength
    Aminocaproic Acid (UNII: U6F3787206) (Aminocaproic Acid - UNII:U6F3787206) Aminocaproic Acid 1000 mg
    Inactive Ingredients
    Ingredient Name Strength
    POVIDONE K30 (UNII: U725QWY32X)  
    CROSPOVIDONE, UNSPECIFIED (UNII: 2S7830E561)  
    Stearic Acid (UNII: 4ELV7Z65AP)  
    Magnesium Stearate (UNII: 70097M6I30)  
    Product Characteristics
    Color WHITE Score 2 pieces
    Shape ROUND Size 22mm
    Flavor Imprint Code 009;009
    Contains     
    Packaging
    # Item Code Package Description Marketing Start Date Marketing End Date
    1 NDC:69680-116-30 30 in 1 BOTTLE; Type 0: Not a Combination Product 12/03/2018
    2 NDC:69680-116-00 100 in 1 BOTTLE; Type 0: Not a Combination Product 12/03/2018
    Marketing Information
    Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
    ANDA ANDA209060 12/03/2018
    Labeler - Vitruvias Therapeutics (079200795)
    Close