Label: ACETAMINOPHEN, CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HBR kit

  • NDC Code(s): 51316-451-01, 51316-983-01, 51316-984-03
  • Packager: CVS Pharmacy, Inc
  • Category: HUMAN OTC DRUG LABEL
  • DEA Schedule: None

Drug Label Information

Updated March 31, 2025

If you are a consumer or patient please visit this version.

  • Day Time Flu Relief Maximum Strength

    Drug Facts

    Active ingredients (in each caplet)

    Acetaminophen 500 mg

    Dextromethorphan HBr 15 mg

    Purposes

    Pain reliever/Fever reducer

    Cough suppressant

    Uses

    • temporarily relieves these symptoms due to a common cold or flu:
      • headache
      • minor aches and pains
      • cough due to minor throat and bronchial irritation
      • minor sore throat pain
    • temporarily reduces fever

    Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

    • more than 4,000 mg of acetaminophen in 24 hours
    • with other drugs containing acetaminophen
    • 3 or more alcoholic drinks every day while using this product

    Allergy alert: Acetaminophen may cause severe skin reactions.

    Symptoms may include: • skin reddening • blisters • rash

    If a skin reaction occurs, stop use and seek medical help right away.

    Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting consult a doctor promptly.

    • in a child under 12 years of age
    • if you are allergic to acetaminophen
    • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
    • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease) or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

    • liver disease
    • a breathing problem such as emphysema or chronic bronchitis
    • cough that occurs with too much phlegm (mucus)
    • cough that lasts or is chronic such as occurs with smoking, asthma or emphysema

    • taking the blood thinning drug warfarin

    When using this product do not use more than directed.

    • pain or cough gets worse or lasts more than 7 days
    • fever gets worse or lasts more than 3 days
    • redness or swelling is present
    • new symptoms occur
    • cough comes back or occurs with a rash or headache that lasts

    These could be signs of a serious condition.

    If pregnant or breast-feeding, ask a doctor before use.

    Keep out of reach of children.

    In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) immediately. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

    Directions

    • do not use more than directed
    • adults and children 12 years and over: take 2 caplets every 6 hours, while symptoms persist
    • do not take more than 6 caplets in 24 hours unless directed by a doctor
    • children under 12 years of age: do not use
      AgeDose
      adults and children 12 years of age and over2 caplets every 6 hours
      children under 12 years of agedo not use

    Other information

    Store in a dry place at 15º - 30°C (59° -86°F).

    corn starch, crospovidone, FD&C blue #2 lake, FD&C red #40 lake, hypromellose, magnesium stearate, medium chain triglycerides,
    microcrystalline cellulose, mineral oil, polydextrose, polyethylene glycol, povidone, sodium starch glycolate, stearic acid, talc, titanium dioxide.

    1-800-231-4670

  • Nighttime Flu Relief Maximu Strength

    Drug facts

    Active ingredients (in each caplet)

    Acetaminophen 500 mg

    Chlorpheniramine maleate 2 mg

    Dextromethorphan HBr 15 mg

    Purposes

    Pain reliever/Fever reducer

    Antihistamine

    Cough suppressant

    Uses

    • temporarily relieves these symptoms due to a common cold or flu:
    • headache
    • minor aches and pains
    • cough due to minor throat and bronchial irritation
    • minor sore throat pain
    • runny nose
    • temporarily reduces fever

    Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take

    • more than 4,000 mg of acetaminophen in 24 hours
    • with other drugs containing acetaminophen
    • 3 or more alcoholic drinks every day while using this product

    Allergy alert: Acetaminophen may cause severe skin reactions.

    Symptoms may include: • skin reddening • blisters • rash

    If a skin reaction occurs, stop use and seek medical help right away.

    Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting consult a doctor promptly.

    • in a child under 12 years of age
    • if you are allergic to acetaminophen
    • with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
    • if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson's disease) or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.

    • liver disease
    • a breathing problem such as emphysema or chronic bronchitis
    • glaucoma
    • trouble urinating due to an enlarged prostate gland
    • cough that occurs with too much phlegm (mucus)
    • cough that lasts or is chronic such as occurs with smoking, asthma or emphysema

    • taking the blood thinning drug warfarin
    • taking sedatives or tranquilizers

    • avoid alcoholic drinks
    • marked drowsiness may occur
    • alcohol, sedatives and tranquilizers may increase drowsiness
    • be careful when driving a motor vehicle or operating machinery
    • excitability may occur, especially in children

    • pain or cough gets worse or lasts more than 7 days
    • fever gets worse or lasts more than 3 days
    • redness or swelling is present
    • new symptoms occur
    • cough comes back or occurs with a rash or headache that lasts

    These could be signs of a serious condition.

    If pregnant or breast-feeding, ask a doctor before use.

    Keep out of reach of children.

    In case of overdose, get medical help or contact a Poison Control Center (1-800-222-1222) immediately. Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

    Directions

    • do not use more than directed
    • adults and children 12 years and over: take 2 caplets every 6 hours, while symptoms persist
    • do not take more than 6 caplets in 24 hours unless directed by a doctor
    • children under 12 years of age: do not use

    AgeDose
    adults and children 12 years of age and over2 caplets every 6 hours
    children under 12 years of agedo not use

    Other information

    Store in a dry place at 15° – 30°C (59° – 86°F).

    corn starch, crospovidone, FD&C blue #2 lake, hypromellose, magnesium stearate, microcrystalline cellulose, mineral oil, polyethylene glycol, povidone, sodium starch glycolate, stearic acid, titanium dioxide, triacetin.

    1-800-231-4670

  • SPL UNCLASSIFIED SECTION

    † These products are not manufactured or distributed by Haleon, distributor of Theraflu.

    Distributed by: CVS Pharmacy, Inc.
    One CVS Drive, Woonsocket, RI 02895
    © 2024 CVS/pharmacy
    CVS.com® 1-800-SHOP CVS

    *Maximum Strength per 6 hour dose.

    TAMPER EVIDENT FEATURE: FLU RELIEF MAX STRENGTH CAPLETS ARE SEALED IN BLISTER PACKETS. USE ONLY IF THE INDIVIDUAL SEAL IS UNBROKEN.

    READ ALL WARNINGS AND DIRECTIONS ON CARTON BEFORE USE.
    KEEP CARTON FOR REFERENCE. DO NOT DISCARD.

    DO NOT TAKE A DOSE OF THE NIGHTTIME PRODUCT SOONER THAN 6 HOURS AFTER
    THE LAST DOSE OF THE DAYTIME PRODUCT UNLESS DIRECTED BY YOUR DOCTOR.

    DO NOT TAKE THE DAYTIME AND NIGHTTIME PRODUCTS AT THE SAME TIME.
    DO NOT TAKE MORE THAN 3 DOSES IN TOTAL IN ANY 24 HOUR PERIOD.

  • PRINCIPAL DISPLAY PANEL

    CVS Health

    Compare to the active ingredients in Theraflu Flu Relief Maximum Strength Daytime & Nighttime caplets†

    Multi-Symptom

    DAYTIME

    MAXIMUM STRENGTH*

    Flu Relief

    ACETAMINOPHEN

    Pain reliever; Fever reducer

    DEXTROMETHORPHAN HBr

    Cough suppressant

    Relieves: Fever, Body aches, Headache, Sore throat pain, Cough

    20 CAPLETS

    NIGHTTIME

    MAXIMUM STRENGTH*

    Flu Relief

    ACETAMINOPHEN

    Pain reliever; Fever reducer

    CHLORPHENIRAMINE MALEATE

    Antihistamine

    DEXTROMETHORPHAN HBr

    Cough suppressant

    Additional relief of: Runny nose

    20 CAPLETS

    40 TOTAL CAPLETS

    CVS label

  • INGREDIENTS AND APPEARANCE
    ACETAMINOPHEN, CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HBR 
    acetaminophen, chlorpheniramine maleate, dextromethorphan hbr kit
    Product Information
    Product TypeHUMAN OTC DRUGItem Code (Source)NDC:51316-984
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:51316-984-031 in 1 CARTON; Type 1: Convenience Kit of Co-Package07/10/2024
    Quantity of Parts
    Part #Package QuantityTotal Product Quantity
    Part 12 BLISTER PACK 20   in 40 
    Part 22 BLISTER PACK 20   in 40 
    Part 1 of 2
    ACETAMINOPHEN, CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HBR 
    acetaminophen, chlorpheniramine maleate, dextromethorphan hbr tablet, film coated
    Product Information
    Item Code (Source)NDC:51316-451
    Route of AdministrationORAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    DEXTROMETHORPHAN HYDROBROMIDE (UNII: 9D2RTI9KYH) (DEXTROMETHORPHAN - UNII:7355X3ROTS) DEXTROMETHORPHAN HYDROBROMIDE15 mg
    ACETAMINOPHEN (UNII: 362O9ITL9D) (ACETAMINOPHEN - UNII:362O9ITL9D) ACETAMINOPHEN500 mg
    CHLORPHENIRAMINE MALEATE (UNII: V1Q0O9OJ9Z) (CHLORPHENIRAMINE - UNII:3U6IO1965U) CHLORPHENIRAMINE MALEATE2 mg
    Inactive Ingredients
    Ingredient NameStrength
    CROSPOVIDONE (UNII: 2S7830E561)  
    FD&C BLUE NO. 2 ALUMINUM LAKE (UNII: 4AQJ3LG584)  
    HYPROMELLOSES (UNII: 3NXW29V3WO)  
    MAGNESIUM STEARATE (UNII: 70097M6I30)  
    POLYETHYLENE GLYCOL, UNSPECIFIED (UNII: 3WJQ0SDW1A)  
    SODIUM STARCH GLYCOLATE TYPE A (UNII: H8AV0SQX4D)  
    STEARIC ACID (UNII: 4ELV7Z65AP)  
    STARCH, CORN (UNII: O8232NY3SJ)  
    TITANIUM DIOXIDE (UNII: 15FIX9V2JP)  
    MICROCRYSTALLINE CELLULOSE (UNII: OP1R32D61U)  
    TRIACETIN (UNII: XHX3C3X673)  
    MINERAL OIL (UNII: T5L8T28FGP)  
    POVIDONE (UNII: FZ989GH94E)  
    Product Characteristics
    ColorblueScoreno score
    ShapeOVALSize18mm
    FlavorImprint Code C451
    Contains    
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:51316-451-0110 in 1 BLISTER PACK; Type 0: Not a Combination Product
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    OTC Monograph DrugM01207/10/2024
    Part 2 of 2
    ACETAMINOPHEN, DEXTROMETHORPHAN HBR 
    acetaminophen, dextromethorphan hbr tablet, film coated
    Product Information
    Item Code (Source)NDC:51316-983
    Route of AdministrationORAL
    Active Ingredient/Active Moiety
    Ingredient NameBasis of StrengthStrength
    DEXTROMETHORPHAN HYDROBROMIDE (UNII: 9D2RTI9KYH) (DEXTROMETHORPHAN - UNII:7355X3ROTS) DEXTROMETHORPHAN HYDROBROMIDE15 mg
    ACETAMINOPHEN (UNII: 362O9ITL9D) (ACETAMINOPHEN - UNII:362O9ITL9D) ACETAMINOPHEN500 mg
    Inactive Ingredients
    Ingredient NameStrength
    TITANIUM DIOXIDE (UNII: 15FIX9V2JP)  
    FD&C BLUE NO. 2 ALUMINUM LAKE (UNII: 4AQJ3LG584)  
    STEARIC ACID (UNII: 4ELV7Z65AP)  
    POVIDONE (UNII: FZ989GH94E)  
    MICROCRYSTALLINE CELLULOSE (UNII: OP1R32D61U)  
    POLYDEXTROSE (UNII: VH2XOU12IE)  
    SODIUM STARCH GLYCOLATE TYPE A (UNII: H8AV0SQX4D)  
    FD&C RED NO. 40 ALUMINUM LAKE (UNII: 6T47AS764T)  
    MINERAL OIL (UNII: T5L8T28FGP)  
    CROSPOVIDONE (UNII: 2S7830E561)  
    MEDIUM-CHAIN TRIGLYCERIDES (UNII: C9H2L21V7U)  
    STARCH, CORN (UNII: O8232NY3SJ)  
    HYPROMELLOSES (UNII: 3NXW29V3WO)  
    POLYETHYLENE GLYCOL, UNSPECIFIED (UNII: 3WJQ0SDW1A)  
    MAGNESIUM STEARATE (UNII: 70097M6I30)  
    TALC (UNII: 7SEV7J4R1U)  
    Product Characteristics
    ColorredScoreno score
    ShapeOVALSize18mm
    FlavorImprint Code C642
    Contains    
    Packaging
    #Item CodePackage DescriptionMarketing Start DateMarketing End Date
    1NDC:51316-983-0110 in 1 BLISTER PACK; Type 0: Not a Combination Product
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    OTC Monograph DrugM01207/10/2024
    Marketing Information
    Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
    OTC Monograph DrugM01207/10/2024
    Labeler - CVS Pharmacy, Inc (062312574)