Label: EPIFOAM- hydrocortisone acetate and pramoxine hydrochloride aerosol, foam

  • NDC Code(s): 68220-144-10
  • Packager: Alaven Pharmaceutical LLC
  • Category: HUMAN PRESCRIPTION DRUG LABEL
  • DEA Schedule: None
  • Marketing Status: Abbreviated New Drug Application

Drug Label Information

Updated 11/09

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  • SPL UNCLASSIFIED SECTION

    topical aerosol

    Rx Only

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  • DESCRIPTION

    Epifoam® (hydrocortisone acetate 1% and pramoxine hydrochloride 1%) is a topical aerosol foam containing: hydrocortisone acetate 1% and pramoxine hydrochloride 1% in a base containing: propylene glycol, cetyl alcohol, glyceryl monostearate and PEG 100 stearate blend, laureth-23, polyoxyl-40 stearate, methylparaben, propylparaben, trolamine, purified water and inert propellants: isobutane and propane.

    Epifoam® contains a synthetic corticosteroid used as an anti-inflammatory/antipruritic agent and a local anesthetic.

    Hydrocortisone acetate

    Molecular weight: 404.50. Solubility of hydrocortisone acetate in water: 1mg/100mL.

    Chemical name: Pregn-4-ene-3, 20-dione, 21-(acetyloxy)-11, 17-dihydroxy-(11β)-.

    Chemical Structure

    Pramoxine hydrochloride

    Molecular weight: 329.86. Pramoxine hydrochloride is freely soluble in water.

    Chemical name: morpholine, 4-[3-(4-butoxyphenoxy) propyl]-, hydrochloride.

    Chemical Structure
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  • CLINICAL PHARMACOLOGY

    Topical corticosteroids share anti-inflammatory, antipruritic and vasoconstrictive actions. The mechanism of anti-inflammatory activity of the topical corticosteroids is unclear. Various laboratory methods, including vasoconstrictor assays, are used to compare and predict potencies and/or clinical efficacies of the topical corticosteroids. There is some evidence to suggest that a recognizable correlation exists between vasoconstrictor potency and therapeutic efficacy in man.

    Pramoxine Hydrochloride

    A surface or local anesthetic which is not chemically related to the "caine" types of local anesthetics. Its unique chemical structure is likely to minimize the danger of cross-sensitivity reactions in patients allergic to other local anesthetics.

    Pharmacokinetics

    The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings.

    Topical corticosteroids can be absorbed from normal intact skin. Inflammation and/or disease processes in the skin increase the percutaneous absorption of topical corticosteroids. Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses. (See DOSAGE AND ADMINISTRATION.)

    Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids. Corticosteroids are bound to plasma proteins in varying degrees. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys. Some of the topical corticosteroids and their metabolites are also excreted into the bile.

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  • INDICATIONS AND USAGE

    Topical corticosteroids are indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

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  • CONTRAINDICATIONS

    Topical corticosteroid products are contraindicated in those patients with a history of hypersensitivity to any of the components of the preparation.

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  • WARNINGS

    Not for prolonged use. If redness, pain, irritation or swelling persists, discontinue use and consult a physician. Contents of the container are under pressure. Do not burn or puncture the aerosol container. Do not store at temperatures above 120°F (49°C). Keep this and all medicines out of the reach of children.

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  • PRECAUTIONS

    General

    Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia and glucosuria in some patients.

    Conditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use and the addition of occlusive dressings.

    Therefore, patients receiving a large dose of a potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, to reduce the frequency of application, or to substitute a less potent steroid.

    Recovery of HPA axis function is generally prompt and complete upon discontinuation of the drug. Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids.

    In pediatric patients absorption may result in higher blood levels and thus more susceptibility to systemic toxicity. (See PRECAUTIONS-Pediatric Use.) If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted.

    In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

    Information for the Patient

    Patients using topical corticosteroids should receive the following information and instructions:

    1. This medication is to be used as directed by the physician. It is for external use only. Avoid contact with the eyes.
    2. Do not use this medication for any disorder other than for which it has been prescribed.
    3. The treated skin area should not be bandaged or otherwise covered or wrapped as to be occlusive unless directed by the physician.
    4. Report any signs of local adverse reactions especially under occlusive dressings.
    5. Do not use any tight fitting diapers or plastic pants on a pediatric patient being treated in the diaper area, as these garments may constitute occlusive dressings.

    Laboratory Tests

    The following tests may be helpful in evaluating the HPA axis suppression:

     
    Urinary free cortisol test
     
    ACTH stimulation test

    Carcinogenesis, Mutagenesis, and Impairment of Fertility

    Long-term animal studies have not been performed to evaluate carcinogenic potential or the effect on fertility of topical corticosteroids.

    Studies to determine mutagenicity with prednisolone and hydrocortisone have revealed negative results.

    Pregnancy Category C

    Corticosteroids are generally teratogenic in laboratory animals when administered systemically at relatively low dosage levels. The more potent corticosteroids have been shown to be teratogenic after dermal application in laboratory animals. There are no adequate and well-controlled studies in pregnant women of teratogenic effects from topically applied corticosteroids. Therefore, topical corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Drugs of this class should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time.

    Nursing mothers

    It is not known whether topical administration of corticosteroids could result in sufficient systemic absorption to produce detectable quantities in breast milk. Systemically administered corticosteroids are secreted into breast milk in quantities not likely to have a deleterious effect on the infant. Caution should be exercised when any topical corticosteroids are administered to a nursing woman.

    Pediatric Use

    PEDIATRIC PATIENTS MAY DEMONSTRATE GREATER SUSCEPTIBILTY TO TOPICAL CORTICOSTEROID-INDUCED HPA AXIS SUPPRESSION AND CUSHING'S SYNDROME THAN MATURE PATIENTS BECAUSE OF A LARGER SKIN SURFACE AREA TO BODY WEIGHT RATIO.

    Hypothalamic-pituitary-adrenal (HPA) axis suppression, Cushing's syndrome and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids. Manifestations of adrenal suppression in pediatric patients include linear growth retardation, delayed weight gain, low plasma cortisone levels and absence of response to ACTH stimulation. Manifestations of intracranial hypertension include bulging fontanelles, headaches, and bilateral papilledema.

    Administration of topical corticosteroids to pediatric patients should be limited to the least amount compatible with an effective therapeutic regimen. Chronic corticosteroid therapy may interfere with the growth and development of pediatric patients.

    Geriatric Use

    Reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious using the least amount compatible with an effective therapeutic regimen and reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.

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  • ADVERSE REACTIONS

    The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximately decreasing order of occurrence:

    Burning, Itching, Irritation, Dryness, Folliculitis, Hypertrichosis, Acneiform eruptions, Hypopigmentation, Perioral dermatitis, Allergic contact dermatitis, Maceration of the skin, Secondary infection, Skin atrophy, Striae, Miliaria

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  • OVERDOSAGE

    Topically applied corticosteroids can be absorbed in sufficient amounts to produce systemic effects. (See PRECAUTIONS.)

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  • DOSAGE AND ADMINISTRATION

    Apply to affected area 3 to 4 times daily.

    Occlusive dressings may be used for the management of psoriasis or recalcitrant conditions. If an infection develops, the use of occlusive dressings should be discontinued and appropriate antimicrobial therapy instituted.

    Directions For Use

    1. Shake the container vigorously for 5-10 seconds before each use.
    2. While holding container upright, prime the container by pressing down several times on container cap until foam appears. Apply a small amount directly to affected area 3-4 times daily depending on severity of the condition. Alternatively, dispense a small amount to a pad and apply to affected areas.
      NOTE: The aerosol container should never be inserted into vagina or anus.
    3. The container and cap should be disassembled and rinsed with warm water after use.
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  • HOW SUPPLIED

    Epifoam® is supplied in 10 g pressurized cans.

     
    NDC 68220-144-10                    10 g

    Store upright at controlled room temperature 20° – 25°C (68° – 77°F). DO NOT REFRIGERATE.

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  • SPL UNCLASSIFIED SECTION

    Marketed and Distributed by:
    ALAVEN®
    PHARMACEUTICAL LLC
    Marietta, GA 30067
    For Medical Inquiries,
    call toll-free 1-888-317-0001
    www.alavenpharm.com

    4009474
    Rev. 08/08

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  • PRINCIPAL DISPLAY PANEL - 10 g Carton

    NDC 68220-144-10
    STORE UPRIGHT

    epifoam®
    (hydrocortisone acetate 1% and
    pramoxine hydrochloride 1%)

    topical aerosol

    Rx Only

    ALAVEN®
    PHARMACEUTICAL LLC

    10 g net wt

    Principal Display Panel - 10 g Carton
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  • PRINCIPAL DISPLAY PANEL - 10 g Label

    NDC 68220-144-10
    STORE UPRIGHT

    10 g net wt

    epifoam®
    (hydrocortisone acetate 1% and
    pramoxine hydrochloride 1%)

    topical aerosol

    Rx Only

    HOLD UPRIGHT TO DISPENSE

    WARNINGS: Contents of
    the container are under
    pressure. Do not burn or
    puncture the aerosol
    container. Do not store at
    temperatures above 120°F
    (49°C).

    Principal Display Panel - 10 g Label
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  • INGREDIENTS AND APPEARANCE
    EPIFOAM 
    hydrocortisone acetate and pramoxine hydrochloride aerosol, foam
    Product Information
    Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:68220-144
    Route of Administration TOPICAL DEA Schedule     
    Active Ingredient/Active Moiety
    Ingredient Name Basis of Strength Strength
    hydrocortisone acetate (hydrocortisone) hydrocortisone 100 mg  in 10 g
    pramoxine hydrochloride (pramoxine) pramoxine 100 mg  in 10 g
    Inactive Ingredients
    Ingredient Name Strength
    propylene glycol  
    cetyl alcohol  
    glyceryl monostearate  
    laureth-23  
    polyoxyl 40 stearate  
    methylparaben  
    propylparaben  
    trolamine  
    water  
    isobutane  
    propane  
    Packaging
    # Item Code Package Description Marketing Start Date Marketing End Date
    1 NDC:68220-144-10 1 in 1 CARTON
    1 10 g in 1 CONTAINER
    Marketing Information
    Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
    ANDA ANDA086457 12/19/1979
    Labeler - Alaven Pharmaceutical LLC (140210829)
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