PROMETHAZINE HYDROCHLORIDE- promethazine hydrochloride tablet 
Advanced Rx Pharmacy of Tennessee, LLC



This is a summary of the most important information about promethazine. For details, talk to your healthcare professional.

What Is Promethazine?

Promethazine is an antihistamine which can be taken by mouth as a tablet or syrup, rectally as a suppository, or by injection. It can be used for:

Who Should Not Use Promethazine?

Promethazine should not be given to:

What Are The Risks?

The following are the major potential risks and side effects of promethazine therapy. However, this list is not complete.

Severe drowsiness and reduced mental alertness. Promethazine may cause drowsiness which may impair your ability to ride a bike, drive a car, or operate machinery. This may be worsened if taken with alcohol or other drugs that also cause central nervous system (CNS) slowing such as sedatives, pain medicines, tranquilizers or certain drugs for depression.

Serious breathing problems. Promethazine should not be used in patients with poor lung function such as chronic obstructive lung disease or breathing problems while sleeping (sleep apnea).

Increased risk of seizures. Promethazine should be used with caution in patients with seizures or who are on other medicines which may also increase the risk of seizures.

Bone-marrow problems and blood cell production. Promethazine should not be used in patients with bone-marrow problems or used with other drugs that affect the bone marrow's production of blood cells.

Neuroleptic malignant syndrome. This potentially deadly syndrome includes symptoms such as fever, muscle rigidity mental changes, changes in pulse or blood pressure, fast heartbeat, increased sweating or irregular heart rhythm.

What Should I Tell My Healthcare Professional?

Before you start taking promethazine, tell your healthcare professional if you:

Can Other Medicines Or Food Affect Promethazine?

Promethazine and certain other medicines can interact with each other. Tell your healthcare professional about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how promethazine works or promethazine may affect how your other medicines work. Know the medicines you take. Keep a list of them with you to show your healthcare professional.

Especially tell your healthcare professional if you take:

Revised: 2/2023
Advanced Rx Pharmacy of Tennessee, LLC