|
MEDICATION GUIDE
|
|
WEGOVY® (wee-GOH-vee)
(semaglutide)
injection, for subcutaneous use
|
WEGOVY® (wee-GOH-vee)
(semaglutide)
tablets, for oral use
|
|
Do not share your pen, Wegovy FlexTouch or needles with other people, even if the needle has been changed. You may give other people a serious infection, or get a serious infection from them.
|
|
Read this Medication Guide and Instructions for Use before you start using WEGOVY and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
|
|
What is the most important information I should know about WEGOVY?
WEGOVY may cause serious side effects, including:
- •
-
Possible thyroid tumors, including cancer. Tell your healthcare provider if you get a lump or swelling in your neck, hoarseness, trouble swallowing, or shortness of breath. These may be symptoms of thyroid cancer. In studies with rodents, WEGOVY and other medicines that work like WEGOVY caused thyroid tumors, including thyroid cancer. It is not known if WEGOVY will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in people.
- •
- Do not use WEGOVY if you or any of your family have ever had a type of thyroid cancer called medullary thyroid carcinoma (MTC), or if you have an endocrine system condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).
|
|
What is WEGOVY?
- •
- WEGOVY injection is a prescription medicine used with a reduced-calorie diet and increased physical activity to:
- o
- reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight.
- o
- help adults and children aged 12 years and older with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to lose weight and keep the weight off.
- o
- treat adults with metabolic dysfunction-associated steatohepatitis (MASH) with moderate to advanced liver scarring (fibrosis), but not with cirrhosis of the liver.
- •
- WEGOVY tablets are a prescription medicine used with a reduced-calorie diet and increased physical activity to:
- o
- reduce the risk of major cardiovascular events such as death, heart attack, or stroke in adults with known heart disease and with either obesity or overweight.
- o
- help adults with obesity, or some adults with excess weight (overweight) who also have weight-related medical problems to lose weight and keep the weight off.
- •
- WEGOVY contains semaglutide and should not be used with other semaglutide-containing products or other GLP-1 receptor agonist medicines.
- •
- It is not known if WEGOVY injection is safe and effective:
- o
- to reduce the risk of major cardiovascular events (death, heart attack, or stroke) in people under 18 years.
- o
- to help children under 12 years of age lose weight and keep the weight off.
- o
- for the treatment of MASH in people under 18 years of age.
- •
- It is not known if WEGOVY tablets are safe and effective for use in people under 18 years of age.
|
|
Do not use WEGOVY if:
- •
- you or any of your family have ever had a type of thyroid cancer called MTC or if you have an endocrine system condition called MEN 2.
- •
- you have had a serious allergic reaction to semaglutide or any of the ingredients in WEGOVY injection or WEGOVY tablets. See the end of this Medication Guide for a complete list of ingredients in WEGOVY injection and WEGOVY tablets. See “What are the possible side effects of WEGOVY?” for symptoms of a serious allergic reaction.
|
|
Before using WEGOVY, tell your healthcare provider if you have any other medical conditions, including if you:
- •
- have or have had problems with your pancreas or kidneys.
- •
- have type 2 diabetes and a history of diabetic retinopathy.
- •
- are scheduled to have surgery or other procedures that use anesthesia or deep sleepiness (deep sedation).
- •
- are pregnant or plan to become pregnant. WEGOVY may harm your unborn baby. You should stop using WEGOVY 2 months before you plan to become pregnant.
- o
-
Pregnancy Exposure Registry: There is a pregnancy exposure registry for women who use WEGOVY during pregnancy. The purpose of this registry is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry or you may contact Novo Nordisk at 1-877-390-2760 or www.wegovypregnancyregistry.com.
- •
- are breastfeeding or plan to breastfeed. Breastfeeding is not recommended during treatment with WEGOVY tablets. It is not known if WEGOVY when received through an injection passes into your breast milk. You should talk with your healthcare provider about the best way to feed your baby while using WEGOVY.
-
-
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. WEGOVY may affect the way some medicines work and some medicines may affect the way WEGOVY works. Tell your healthcare provider if you are taking other medicines to treat diabetes, including sulfonylureas or insulin. WEGOVY slows stomach emptying and can affect medicines that need to pass through the stomach quickly.
Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.
|
|
How should I use WEGOVY?
- •
- Use WEGOVY exactly as your healthcare provider tells you to.
- •
- Use WEGOVY with a reduced-calorie diet and increased physical activity.
- •
- If you take too much WEGOVY, you may have severe nausea, severe vomiting and severe low blood sugar. Call your healthcare provider or Poison Help line at 1-800-222-1222 or go to the nearest hospital emergency room right away. Advice is also available online at poisonhelp.org.
WEGOVY Injection
- •
- Read the Instructions for Use that comes with WEGOVY.
- •
-
Your healthcare provider should tell you which WEGOVY product you will be using (for example – single-dose pen or syringe, single-patient-use pen, or tablets). Before you use WEGOVY injection for the first time, your healthcare provider should show you how to use it. Once you have been trained, you may inject WEGOVY yourself if your healthcare provider determines that you are able to do so safely. If you are visually impaired, the WEGOVY FlexTouch pen is not recommended for self-injection.
- •
- If you are prescribed a different WEGOVY product at any point, make sure you receive new training for the new product and read the Instructions for Use that come with it.
- •
- WEGOVY is injected under the skin (subcutaneously) of your stomach (abdomen), thigh, or upper arm. Do not inject WEGOVY into a muscle (intramuscularly) or vein (intravenously).
- •
- Change (rotate) your injection site with each injection. Do not use the same site for each injection.
- •
-
Use WEGOVY 1 time each week, on the same day each week, at any time of the day.
- •
- If you need to change the day of the week, you may do so as long as your last dose of WEGOVY was given 2 or more days before.
- •
- If you miss a dose of WEGOVY and the next scheduled dose is more than 2 days away (48 hours), take the missed dose as soon as possible. If you miss a dose of WEGOVY and the next scheduled dose is less than 2 days away (48 hours), do not administer the dose. Take your next dose on the regularly scheduled day.
- •
- If you miss doses of WEGOVY for 2 or more consecutive weeks, contact your healthcare provider to talk about how to restart your treatment.
- •
- You can take WEGOVY with or without food.
WEGOVY Tablets
- •
- Take 1 WEGOVY tablet by mouth on an empty stomach in the morning with water (no more than 4 ounces). Do not take WEGOVY tablets with any other liquids besides water.
- •
-
Do not split, crush, chew or dissolve WEGOVY tablets. Swallow WEGOVY tablets whole.
- •
-
Do not take more than 1 WEGOVY tablet each day.
- •
- After 30 minutes, you can eat, drink, or take other oral medicines.
- •
- If you miss a dose of WEGOVY, skip the missed dose and go back to your regular schedule for the next dose.
|
|
What are the possible side effects of WEGOVY?
WEGOVY may cause serious side effects, including:
- •
-
See “What is the most important information I should know about WEGOVY?”
- •
-
inflammation of your pancreas (pancreatitis). Stop using WEGOVY and call your healthcare provider right away if you have severe pain in your stomach area (abdomen) that will not go away, with or without nausea or vomiting. Sometimes you may feel the pain from your abdomen to your back.
- •
-
gallbladder problems. WEGOVY may cause gallbladder problems including gallstones. Some gallbladder problems need surgery. Call your healthcare provider if you have any of the following symptoms:
|
- o
- pain in your upper stomach (abdomen)
|
- o
- yellowing of skin or eyes (jaundice)
|
- o
- fever
|
- o
- clay-colored stools
|
- •
-
increased risk of low blood sugar (hypoglycemia) in patients with type 2 diabetes, especially those who also take medicines to treat type 2 diabetes mellitus such as an insulin or a sulfonylureas. Low blood sugar in patients with type 2 diabetes who receive WEGOVY can be both a serious and common side effect. Talk to your healthcare provider about how to recognize and treat low blood sugar. You should check your blood sugar before you start taking WEGOVY and while you take WEGOVY. Signs and symptoms of low blood sugar may include:
|
- o
- dizziness or light-headedness
|
- o
- sweating
|
- o
- shakiness
|
- o
- blurred vision
|
- o
- slurred speech
|
- o
- weakness
|
- o
- anxiety
|
- o
- hunger
|
- o
- headache
|
- o
- irritability or mood changes
|
- o
- confusion or drowsiness
|
- o
- fast heartbeat
|
| |
- o
- feeling jittery
|
- •
-
dehydration leading to kidney problems. Diarrhea, nausea, and vomiting may cause a loss of fluids (dehydration) which may cause kidney problems. It is important for you to drink fluids to help reduce your chance of dehydration. Tell your healthcare provider right away if you have nausea, vomiting, or diarrhea that does not go away.
- •
-
severe stomach problems. Stomach problems, sometimes severe, have been reported in people who use WEGOVY. Tell your healthcare provider if you have stomach problems that are severe or will not go away.
- •
-
serious allergic reactions. Stop using WEGOVY and get medical help right away, if you have any symptoms of a serious allergic reaction including:
|
- o
- swelling of your face, lips, tongue or throat
|
- o
- severe rash or itching
|
- o
- very rapid heartbeat
|
- o
- problems breathing or swallowing
|
- o
- fainting or feeling dizzy
| |
- •
-
change in vision in people with type 2 diabetes. Tell your healthcare provider if you have changes in vision during treatment with WEGOVY.
- •
-
increased heart rate. WEGOVY can increase your heart rate while you are at rest. Your healthcare provider should check your heart rate while you take WEGOVY. Tell your healthcare provider if you feel your heart racing or pounding in your chest and it lasts for several minutes.
- •
-
food or liquid getting into the lungs during surgery or other procedures that use anesthesia or deep sleepiness (deep sedation). WEGOVY may increase the chance of food getting into your lungs during surgery or other procedures. Tell all your healthcare providers that you are taking WEGOVY before you are scheduled to have surgery or other procedures.
-
-
The most common side effects of WEGOVY in adults or children aged 12 years and older may include:
|
- •
- nausea
|
- •
- stomach (abdomen) pain
|
- •
- dizziness
|
- •
- gas
|
- •
- diarrhea
|
- •
- changes in skin sensations
|
- •
- feeling bloated
| |
- •
- vomiting
|
- •
- headache
|
- •
- belching
|
- •
- stomach flu
|
- •
- constipation
|
- •
- tiredness (fatigue)
- •
- upset stomach
|
- •
- low blood sugar in people with type 2 diabetes
|
- •
- heartburn
- •
- hair loss
|
|
Talk to your healthcare provider about any side effect that bothers you or does not go away. These are not all the possible side effects of WEGOVY.
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1‑800‑FDA‑1088.
|
|
How should I store WEGOVY?
WEGOVY injection
- •
- Do not store WEGOVY in the freezer or directly beside the refrigerator cooling element.
- •
-
Do not freeze WEGOVY and do not use WEGOVY if it has been frozen.
- •
-
WEGOVY single-dose pen and single-dose syringe:
- o
- Store in the refrigerator between 36°F to 46°F (2°C to 8°C).
- o
- If needed, before removing the pen or syringe cap, WEGOVY single-dose pen and single-dose syringe can be stored from 46°F to 86°F (8°C to 30°C) in the original carton for up to 28 days.
- o
- Keep WEGOVY single-dose pen and syringe in the original carton to protect it from light.
- o
- Throw away the WEGOVY single-dose pen or syringe if it has been frozen, has been exposed to light or temperatures above 86°F (30°C), has been out of the refrigerator for 28 days or longer, or after use.
- •
-
WEGOVY FlexTouch single-patient-use pen:
- o
- Store in the refrigerator between 36°F to 46°F (2°C to 8°C).
- o
- After first use, store WEGOVY FlexTouch pen between 59°F to 86°F (15°C to 30°C) or in the refrigerator between 36°F to 46°F (2°C to 8°C) for up to 56 days.
- o
- Protect WEGOVY FlexTouch pen from excessive heat and light.
- o
- Keep the pen cap on when not in use.
- o
- Always remove and safely discard the needle after each injection.
- o
- Store WEGOVY FlexTouch pen without an injection needle attached.
- o
- Always use a new needle for each injection.
- o
- Throw away if the WEGOVY FlexTouch pen if it has been frozen, has been exposed to light or temperatures above 86°F (30°C), or has been out of the refrigerator for 56 days or longer.
WEGOVY tablets
- •
- Store WEGOVY tablets at room temperature between 68°F to 77°F (20°C to 25°C).
- •
- Store tablets in the original closed WEGOVY bottle until you are ready to take one. Do not store in any other container.
- •
- Store in a dry place away from moisture.
Keep WEGOVY and all medicines out of the reach of children.
|
|
General information about the safe and effective use of WEGOVY.
Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use WEGOVY for a condition for which it was not prescribed. Do not give WEGOVY to other people, even if they have the same condition that you have. It may harm them. You can ask your pharmacist or healthcare provider for information about WEGOVY that is written for health professionals.
|
|
What are the ingredients in WEGOVY?
Active Ingredient: semaglutide
Inactive Ingredients in WEGOVY injection:disodium phosphate dihydrate, sodium chloride, water for injection. Phenol and propylene glycol are also inactive ingredients in the single-patient-use WEGOVY FlexTouch. Hydrochloric acid or sodium hydroxide may be added to adjust pH.
Inactive Ingredients in WEGOVY tablets: salcaprozate sodium (SNAC) and magnesium stearate
|
|
Marketed by: Novo Nordisk Inc., Plainsboro, NJ 08536
WEGOVY® and FlexTouch® are registered trademarks of Novo Nordisk A/S.
Patent Information: http://novonordisk-us.com/products/product-patents.html
© 2026 Novo Nordisk
For more information, go to startWegovy.com or call 1-833-Wegovy-1.
|