Medication Guide for Non-Steroidal

Anti-Inflammatory Drugs (NSAIDs)

(See the end of this Medication Guide for a list of

prescription NSAID medicines)

What is the most important information I should know

about medicines called Non-Steroidal Anti-Inflammatory

Drugs (NSAIDs)?

NSAID medicines may increase the chance of a heart attack

or stroke that can lead to death.This chance increases:

-with longer use of NSAID medicines

-in people who have heart disease

NSAID medicines should never be used right before or after

a heart surgery called a "coronary artery bypass

graft (CABG)."

NSAID medicines can cause ulcers and bleeding in the

stomach and intestines at any time during treatment.

Ulcers and bleeding:

-can happen without warning symptoms

-may cause death.

The chance of a person getting an ulcer or bleeding

increases with:

-taking medicines called "corticosteroids" and "anticoagulants"

-longer use

-smoking

-drinking alcohol

-older age

-having poor health

NSAID medicines should only be used:

-exactly as prescribed

-at the lowest dose possible for your treatment

-for the shortest time needed

What are Non-Steroidal Anti-Inflammatory Drugs

(NSAIDs)?

NSAID medicines are used to treat pain and redness, swelling,

and heat (inflammation) form medical conditions such as:

-different types of arthritis

-menstrual cramps and other types of short-term pain

Who should not take a Non-Steroidal Anti-Inflammatory

Drug (NSAID)?

Do not take an NSAID medicine:

-if you had an asthma attack, hives, or other allergic

reaction with aspirin or any other NSAID medicine

-for pain right before or after heart bypass surgery

Tell your healthcare provider:

-about all of your medical conditions

-about all of the medicines you take. NSAIDs and some

other medicines can interact with each other and cause

serious side effects. Keep a list of your medicines to

show to your healthcare provider and pharmacist.

-if you are pregnant. NSAID medicines should not be

used by pregnant women late in their pregnancy.

-if you are breastfeeding. Talk to your doctor.

What are the possible side effects of Non-Steroidal Anti-

Inflammatory Drugs (NSAIDs)?

Serious side effects include:                    Other side effects include:

-heart attack                                                -stomach pain

-stroke                                                         -constipation

-high blood pressure                                     -diarrhea

-heart failure from body

swelling (fluid retention)                                -gas

-kidney problems including

kidney failure                                               -heartburn

-bleeding and ulcers in the stomach

and intestines                                              -nausea

-low red blood cells

(anemia)                                                     -vomiting

-life-threatening skin

reactions                                                    -dizziness

-life-threatening allergic reactions

-liver problems including liver failure

-asthma attacks in people who have asthma

Get emergency help right away if you have any of the

following symptoms:

-shortness of breath or trouble breathing

-chest pain

-weakness in one part or side of your body

-slurred speech

-swelling of the face or throat

Stop your NSAID medicine and call your healthcare provider

right away if you have any of the following symptoms:

-nausea

-more tired or weaker than usual

-itching

-your skin or eyes look yellow

-stomach pain

-flu-like symptoms

-vomit blood

-there is blood in your bowel movement or it is black and

sticky like tar

-unusual weight gain

-skin rash or blisters with fever

-swelling of the arms and legs, hands and feet

These are not all the side effects with NSAID medicines. Talk

to your healthcare provider or pharmacist for more information

about NSAID medicines.

Other information about Non-Steroidal Anti-Inflammatory

Drugs (NSAIDs)

-Aspirin is an NSAID medicine but it does not increase the

chance of a heart attack. Aspirin can cause bleeding in the

brain, stomach and intestines. Aspirin can also cause

ulcers in the stomach and intestines.

-Some of these NSAID medicines are sold in lower doses

without a prescription (over - the - counter). Talk to your

healthcare provider before using over - the - counter NSAIDs

for more than 10 days.

NSAID medicines that need a prescription

Generic Name                                  Tradename

Celecoxib                                           Celebrex

Diclofenac                                          Cataflam, Voltaren, Arthrotec (combined with misoprostol)

Diflunisal                                            Dolobid

Etodolac                                             Lodine, Lodine XL

Fenoprofen                                         Nalfrom, Nalfrom 200

Flurbiprofen                                         Ansaid

Ibuprofen                                             Motrin, Tab-Profen, Vicoprofen (combined with hydrocodone), Combunox (combined with oxycodone)

Indomethacin                                       Indocin, Indocin SR, Indo-Lemmon, Indomethagan

Ketoprofen                                           Oruvail

Ketorolac                                              Toradol

Mefanamic Acid                                     Ponstel

Meloxicam                                             Mobic

Nabumetone                                          Relafen

Naproxen                                               Naprosyn, Anaprox, Anaprox DS, EC-Naproxyn, Neprelan, Naprapac (copackaged with lansoprazole)

Oxaprozin                                              Daypro

Piroxicam                                               Feldene

Sulindac                                                 Clinoril

Tolmetin                                                 Tolectin, Tolectin DS, Tolectin 600

-Vicoprofen contains the same dose of ibuprofen as over - the - counter

(OTC) NSAIDs, and is usually used for less than 10 days to

treat pain. The OTC NSAID label warns that long term continuous

use may increase the risk of heart attack or stroke.

These are not all the side effects with NSAID medicines. Talk

to your healthcare provider or pharmacist for more information

and NSAID medicines. Call your doctor for medical advice

about side effects. You may report side effects to FDA

at 1-800-FDA-1088 and / or Able Wholesalers at

1-800-430-9814.

This Medication Guide has been approved by the U.S. Food

and Drug Administration

Revision: R306/09

Distributed by:

Able Wholesalers

1329A Baptist World Center Dr.

Nashville, TN  37207

1-800-430-9814