REBIF - interferon beta-1a
REBIF REBIDOSE - interferon beta-1a
REBIF- interferon beta-1a  injection, solution
REBIF - interferon beta-1a injection, solution
REBIF REBIDOSE- interferon beta-1a  injection, solution
EMD Serono, Inc.

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MEDICATION GUIDE
REBIF
interferon beta-1a
Injection for subcutaneous use

Read this Medication Guide before you start using REBIF and each time you get a refill. There may be new information. The information does not take the place of talking with your healthcare provider about your medical condition or your treatment.

What is the most important information I should know about REBIF?

REBIF can cause serious side effects . Tell your healthcare provider right away if you have any of the symptoms listed below while taking REBIF.

1.
Behavioral health problems including depression and suicidal thoughts . You may have mood problems including:
  • depression (feeling hopeless or feeling bad about yourself)
  • thoughts of hurting yourself or suicide
2.
Liver problems or worsening of liver problems including liver failure . Symptoms may include:
  • nausea
  • loss of appetite
  • tiredness
  • dark colored urine and pale stools
  • yellowing of your skin or the white part of your eye
  • bleeding more easily than normal
  • confusion
  • sleepiness
During your treatment with REBIF you will need to see your healthcare provider regularly and have regular blood tests to check for side effects.
3.
Serious allergic and skin reactions . Symptoms may include:
  • itching
  • swelling of your face, eyes, lips, tongue or throat
  • trouble breathing
  • anxiousness
  • feeling faint
  • skin rash, hives, sores in your mouth, or skin blisters and peels
4.
Injection site problems . Symptoms at the injection site may include:
  • redness
  • pain
  • swelling
  • color changes (blue or black)
  • drainage of fluid

What is REBIF?

REBIF is a prescription medicine used to treat relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults. It is a form of protein called beta interferon that is produced in the body.

It is not known if REBIF is safe and effective in children.

Who should not take REBIF?

Do not take REBIF if you:

What should I tell my healthcare provider before taking REBIF?

Before you take REBIF, tell your healthcare provider if have or have had any of the following conditions:

Tell your healthcare provider about all medicines you take , including prescription and over-the-counter medicines, vitamins and herbal supplements.

REBIF and other medicines may affect each other causing side effects.

Ask your healthcare provider or pharmacist for a list of these medicines, if you are not sure.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I use REBIF?

What are the possible side effects of REBIF?

REBIF may cause serious side effects, including:

The most common side effects of REBIF include:

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of REBIF. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

How should I store REBIF?

Keep REBIF and all medicines out of the reach of children.

General information about the safe and effective use of REBIF

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use REBIF for a condition for which it was not prescribed. Do not give REBIF to other people, even if they have they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about REBIF. If you would like more information, talk with your healthcare provider. You may ask your healthcare provider or pharmacist for information about REBIF that is written for healthcare professionals.

For more information, go to www.REBIF.com or call toll-free 1-877-447-3243.

What are the ingredients in REBIF?

Active ingredient: interferon beta-1a

Inactive ingredients: albumin (human), mannitol, sodium acetate, water for injection

This Medication Guide has been approved by the U.S. Food and Drug Administration.

07/2019

Revised: 7/2019
EMD Serono, Inc.