MS CONTIN- morphine sulfate tablet 
Rhodes Pharmaceuticals L.P.


Medication Guide
MS CONTIN® (MS-KON-tin) (morphine sulfate extended-release tablets), CII
This Medication Guide has been approved by the U.S. Food and Drug Administration.Revised: 12/2023
  • A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage severe and persistent pain that required an extended treatment period with a daily opioid pain medicine, when other pain medicines do not treat your pain well enough or you cannot tolerate them.
  • A long-acting (extended-release) opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death.
  • Not to be taken on an "as needed" basis.
Important information about MS CONTIN:
  • Get emergency help or call 911 right away if you take too much MS CONTIN (overdose). When you first start taking MS CONTIN, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur. Talk to your healthcare provider about naloxone, a medicine for the emergency treatment of an opioid overdose.
  • Taking MS CONTIN with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
  • Never give anyone else your MS CONTIN. They could die from taking it. Selling or giving away MS CONTIN is against the law.
  • Store MS CONTIN securely, out of sight and reach of children, and in a location not accessible by others, including visitors to the home.
Do not take MS CONTIN if you have:
  • severe asthma, trouble breathing, or other lung problems.
  • a bowel blockage or have narrowing of the stomach or intestines.
Before taking MS CONTIN, tell your healthcare provider if you have a history of:
  • Head injury, seizures
  • problems urinating
  • liver, kidney, thyroid problems
  • pancreas or gallbladder problems
  • abuse of street or prescription drugs, alcohol addiction, opioid overdose, or mental health problems.
Tell your healthcare provider if you are:
  • Noticing your pain getting worse. If your pain gets worse after you take MS CONTIN, do not take more of MS CONTIN without first talking to your healthcare provider. Talk to your healthcare provider if the pain you that have increases, if you feel more sensitive to pain, or if you have new pain after taking MS CONTIN.
  • Pregnant or planning to become pregnant. Use of MS CONTIN for an extended period of time during pregnancy can cause withdrawal symptoms in your newborn baby that could be life- threatening if not recognized and treated.
  • Breastfeeding. Not recommended during treatment with MS CONTIN. It may harm your baby.
  • Living in a household where there are small children or someone who has abused street or prescription drugs.
  • Taking prescription or over-the-counter medicines, vitamins, or herbal supplements. Taking MS CONTIN with certain other medicines can cause serious side effects.
When taking MS CONTIN:
  • Do not change your dose. Take MS CONTIN exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest duration.
  • Take your prescribed dose every 8 to 12 hours, as directed by your healthcare provider. Do not take more than your prescribed dose. If you miss a dose, take your next dose at the usual time.
  • Swallow MS CONTIN whole. Do not cut, break, chew, crush, dissolve, snort, or inject MS CONTIN because this may cause you to overdose and die.
  • Call your healthcare provider if the dose you are taking does not control your pain.
  • Do not stop taking MS CONTIN without talking to your healthcare provider.
  • Dispose of expired, unwanted, or unused MS CONTIN by promptly flushing down the toilet, if a drug take-back option is not readily available. Visit for additional information on disposal of unused medicines.
While taking MS CONTIN DO NOT:
  • Drive or operate heavy machinery, until you know how MS CONTIN affects you. MS CONTIN can make you sleepy, dizzy, or lightheaded.
  • Drink alcohol or use prescription or over-the-counter medicines that contain alcohol. Using products containing alcohol during treatment with MS CONTIN may cause you to overdose and die.
The possible side effects of MS CONTIN are:
  • Constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain. Call your healthcare provider if you have any of these symptoms and they are severe.
Get emergency medical help or call 911 right away if you have:
  • trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue or throat, extreme drowsiness, light-headedness when changing positions, feeling faint, agitation, high body temperature, trouble walking, stiff muscles, or mental changes such as confusion.
These are not all the possible side effects of MS CONTIN. Call your healthcare provider for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information, go to
Manufactured by: Purdue Pharma L.P., Stamford, CT 06901-3431, or call 1-888-726-7535
Marketed by: Rhodes Pharmaceuticals, Wilson, NC 27893 US,, or call 1-888-827-0616.
Revised: 12/2023
Rhodes Pharmaceuticals L.P.