VENLAFAXINE - venlafaxine hydrochloride tablet 
Aurobindo Pharma Limited


Medication Guide

Venlafaxine Tablets, USP

(ven'' la fax' een hye'' droe klor' ide)

Read the Medication Guide that comes with venlafaxine tablets before you start taking them and each time you get a refill. There may be new information. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or treatment. Talk with your healthcare provider if there is something you do not understand or want to learn more about.

What is the most important information I should know about venlafaxine tablets?

Venlafaxine tablets
and other antidepressant medicines may cause serious side effects, including:

1. Suicidal thoughts or actions:

Keep all follow-up visits with your healthcare provider and call between visits if you are worried about symptoms. 
Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency, especially if they are new, worse, or worry you:

Call your healthcare provider right away if you have any of the following symptoms, or call 911 if an emergency. Venlafaxine tablets may be associated with these serious side effects:

2. Serotonin Syndrome

This condition can be life-threatening and may include:

3. Changes in blood pressure. Venlafaxine tablets may:

4. Enlarged pupils (mydriasis).

5. Sexual problems (dysfunction).
Taking serotonin and norepinephrine reuptake inhibitors (SNRIs), including venlafaxine tablets, may cause sexual problems.

Symptoms in males may include:

Symptoms in females may include:

Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment with venlafaxine tablets. There may be treatments your healthcare provider can suggest.

6. Anxiety and insomnia.

7. Changes in appetite or weight.

8. Manic/hypomanic episodes:

9. Low salt (sodium) levels in the blood.

Elderly people may be at greater risk for this. Symptoms may include:

10. Seizures or convulsions.

11. Abnormal bleeding: Venlafaxine tablets and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAIDs, like ibuprofen or naproxen), or aspirin.

12. Elevated cholesterol.

13. Lung disease and pneumonia: Venlafaxine tablets may cause rare lung problems. Symptoms include:

14. Severe allergic reactions:

15. Visual problems.

Only some people are at risk for these problems. You may want to undergo an eye examination to see if you are at risk and receive preventative treatment if you are.

Do not stop venlafaxine tablets without first talking to your healthcare provider.

Stopping venlafaxine tablets too quickly or changing from another antidepressant too quickly may cause serious symptoms including:

What are venlafaxine tablets?

Venlafaxine tablets
are a prescription medicine used to treat depression. It is important to talk with your healthcare provider about the risks of treating depression and also the risks of not treating it. You should discuss all treatment choices with your healthcare provider.

Talk to your healthcare provider if you do not think that your condition is getting better with venlafaxine tablets treatment.

Who should not take venlafaxine tablets?

Do not take venlafaxine tablets if you:  

People who take venlafaxine tablets close in time to an MAOI may have serious or even life-threatening side effects. Get medical help right away if you have any of these symptoms: 

What should I tell my healthcare provider before taking venlafaxine tablets? Ask if you are not sure.

Before starting venlafaxine tablets, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines that you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Venlafaxine tablets and some medicines may interact with each other, may not work as well, or may cause serious side effects.

Your healthcare provider or pharmacist can tell you if it is safe to take venlafaxine tablets with your other medicines. Do not start or stop any medicine while taking venlafaxine tablets without talking to your healthcare provider first.

 If you take venlafaxine tablets, you should not take any other medicines that contain (venlafaxine) including: venlafaxine hydrochloride.

How should I take venlafaxine tablets?

  • Take venlafaxine tablets exactly as prescribed. Your healthcare provider may need to change the dose of venlafaxine tablets until it is the right dose for you.
  • Venlafaxine tablets are to be taken with food.
  • If you miss a dose of venlafaxine tablets, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of venlafaxine tablets at the same time.
  • If you take too much venlafaxine hydrochloride, call your healthcare provider or poison control center right away, or get emergency treatment.
  • When switching from another antidepressant to venlafaxine tablets your doctor may want to lower the dose of the initial antidepressant first to avoid side effects.

What should I avoid while taking venlafaxine tablets?

Venlafaxine tablets can cause sleepiness or may affect your ability to make decisions, think clearly, or react quickly. You should not drive, operate heavy machinery, or do other dangerous activities until you know how venlafaxine tablets affect you. Do not drink alcohol while using venlafaxine tablets.

What are the possible side effects of venlafaxine tablets?

Venlafaxine tablets may cause serious side effects, including:

  • See “What is the most important information I should know about venlafaxine tablets?”
  • Increased cholesterol- have your cholesterol checked regularly
  • Newborns whose mothers take venlafaxine tablets in the third trimester may have problems right after birth including:
    • problems feeding and breathing
    • seizures
    • shaking, jitteriness or constant crying
  • Narrow-angle glaucoma/enlarged pupils. Check eye pressure regularly if you:
    • have a history of increased eye pressure
    • are at risk for certain types of glaucoma

Common possible side effects in people who take venlafaxine tablets include:

  • unusual dreams
  • sexual problems
  • loss of appetite, constipation, diarrhea, nausea or vomiting, or dry mouth
  • feeling tired, fatigued or overly sleepy
  • change in sleep habits, problems sleeping
  • yawning
  • tremor or shaking
  • dizziness, blurred vision
  • sweating
  • feeling anxious, nervous or jittery
  • headache
  • increase in heart rate

Tell your healthcare provider if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of venlafaxine tablets. For more information, ask your healthcare provider or pharmacist.


How should I store venlafaxine tablets?

  • Store venlafaxine tablets at room temperature between 20° to 25°C (68° to 77°F). 
  • Keep venlafaxine tablets in a dry place.

Keep venlafaxine tablets and all medicines out of the reach of children.

General information about venlafaxine tablets

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use venlafaxine tablets for a condition for which it was not prescribed. Do not give venlafaxine tablets to other people, even if they have the same condition. They may harm them.

This Medication Guide summarizes the most important information about venlafaxine tablets. If you would like more information, talk with your healthcare provider. You may ask your healthcare provider or pharmacist for information about venlafaxine tablets that is written for healthcare professionals.

For more information about venlafaxine tablets call 1-866-850-2876.

What are the ingredients in venlafaxine tablets

Active ingredient: venlafaxine hydrochloride

Inactive ingredients:

  • Tablets: lactose monohydrate, microcrystalline cellulose, sodium starch glycolate, ferric oxide brown, ferric oxide yellow, povidone (Kollidone 30), and magnesium stearate.

This Medication Guide has been approved by the U.S. Food and Drug Administration for all antidepressants.

Coumadin® is a registered trademark of Bristol Myers Squibb.
Jantoven® is a registered trademark of Upsher-Smith Laboratories Inc.

Dispense with Medication Guide available at:

Distributed by:
Aurobindo Pharma USA, Inc.
279 Princeton-Hightstown Road
East Windsor, NJ 08520

Manufactured by:
Aurobindo Pharma Limited
Hyderabad–500 032, India

Revised: 08/2023

Revised: 8/2023
Aurobindo Pharma Limited