TETRABENAZINE- tetrabenazine tablet 
TAGI Pharma, Inc.

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MEDICATION GUIDE

Tetrabenazine (TET ra BEN a Zeen) Tablets

Read the Medication Guide that comes with Tetrabenazine tablet before you start taking it and each time you refill the prescription. There may be new information. This information does not take the place of talking with your doctor about your medical condition or your treatment. You should share this information with your family members and caregivers.

What is the most important information I should know about Tetrabenazine tablet?

  • Tetrabenazine tablet can cause serious side effects, including:
    • depression
    • suicidal thoughts
    • suicidal actions
  • You should not start taking Tetrabenazine tablet if you are depressed (have untreated depression or depression that is not well controlled by medicine) or have suicidal thoughts.
  • Pay close attention to any changes, especially sudden changes, in mood, behaviors, thoughts or feelings. This is especially important when Tetrabenazine tablet is started and when the dose is changed.

Call the doctor right away if you become depressed or have any of the following symptoms, especially if they are new, worse, or worry you:

  • feel sad or have crying spells
  • loose interest in seeing your friends or doing things you used to enjoy
  • sleep a lot more or a lot less than usual
  • feel unimportant
  • feel guilty
  • feel hopeless or helpless
  • more irritable, angry or aggressive than usual
  • more or less hungry than usual or notice a big change in your body weight
  • have trouble paying attention
  • feel tired or sleepy all the time
  • have thoughts about hurting yourself or ending your life

What is Tetrabenazine tablet?

Tetrabenazine tablet is a medicine that is used to treat the involuntary movements (chorea) of Huntington's disease. Tetrabenazine tablet does not cure the cause of the involuntary movements, and it does not treat other symptoms of Huntington's disease, such as problems with thinking or emotions.

It is not known whether Tetrabenazine tablet is safe and effective in children.

Who should not take Tetrabenazine tablet?

Do not take Tetrabenazine tablet if you:

  • are depressed or have thoughts of suicide. See "What is the most important information I should know about Tetrabenazine tablet?"
  • have liver problems.
  • are taking a monoamine oxidase inhibitor (MAOI) medicine. Ask your doctor or pharmacist if you are not sure.
  • are taking reserpine. Do not take medicines that contain reserpine (such as Serpalan® and Renese®-R) with Tetrabenazine tablet. If your doctor plans to switch you from taking reserpine to Tetrabenazine tablet, you must wait at least 20 days after your last dose of reserpine before you start taking Tetrabenazine tablet.

What should I tell my doctor before taking Tetrabenazine tablet?

Tell your doctor about all your medical conditions, including if you:

  • have emotional or mental problems (for example, depression, nervousness, anxiety, anger, agitation, psychosis, previous suicidal thoughts or suicide attempts).
  • have liver disease.
  • have any allergies. See the end of this Medication Guide for a complete list of the ingredients in Tetrabenazine tablet.
  • have breast cancer or a history of breast cancer.
  • have heart disease that is not stable, have heart failure or recently had a heart attack.
  • have an irregular heartbeat (cardiac arrhythmia).
  • are pregnant or plan to become pregnant. It is not known if Tetrabenazine tablet can harm your unborn baby.
  • are breast-feeding. It is not known if TETRABENAZINE passes into breast milk.

Tell your doctor about all the medicines you take, including prescription medicines and nonprescription medicines, vitamins and herbal products. Using Tetrabenazine tablet with certain other medicines may cause serious side effects. Do not start any new medicines while taking Tetrabenazine tablet without talking to your doctor first.

How sho uld I take Tetrabenazine tablet?

  • Tetrabenazine tablet is a tablet that you take by mouth.
  • Take Tetrabenazine tablet exactly as prescribed by your doctor.
  • You may take Tetrabenazine tablet with or without food.
  • Your doctor will increase your dose of Tetrabenazine tablet each week for several weeks, until you and your doctor find the best dose for you.
  • If you stop taking Tetrabenazine tablet or miss a dose, your involuntary movements may return or worsen in 12 to 18 hours after the last dose.
  • Before starting Tetrabenazine tablet, you should talk to your health care provider about what to do if you miss a dose. If you miss a dose and it is time for your next dose, do not double the dose.
  • Tell your doctor if you stop taking Tetrabenazine tablet for more than 5 days. Do not take another dose until you talk to your doctor.
  • If your doctor thinks you need to take more than 50 mg of TETRABENAZINE each day, you will need to have a blood test to see if it is safe for you.

What sho uld I avo id while taking Tetrabenazine tablet?

Sleepiness (sedation) is a common side effect of Tetrabenazine tablet. While taking Tetrabenazine tablet, do not drive a car or operate dangerous machinery until you know how TETRABENAZINE affects you. Drinking alcohol and taking other drugs that may also cause sleepiness while you are taking Tetrabenazine tablet may increase any sleepiness caused by TETRABENAZINE.

What are the possible side effects of Tetrabenazine tablet?

Tetrabenazine tablet can cause serious side effects, including:

  • Depression, suicidal thoughts, or actions. See "What is the most important information I should know about Tetrabenazine?"
  • Neuroleptic Malignant Syndrome (NMS).Call your doctor right away and go to the nearest emergency room if you develop these signs and symptoms that do not have another obvious cause:
    • high fever
    • stiff muscles
    • problems thinking
    • very fast or uneven heartbeat
    • increased sweating
  • Parkinsonism. Symptoms of Parkinsonism include: slight shaking, body stiffness, trouble moving or keeping your balance.
  • Restlessness. You may get a condition where you feel a strong urge to move. This is called akathisia.
  • Trouble swallowing. Tetrabenazine tablet may increase the chance that you will have trouble swallowing. Increased coughing may be the first sign that you are having trouble swallowing. Trouble swallowing increases your risk of pneumonia.
  • Irregular heartbeat. Tetrabenazine tablet increases your chance of having certain changes in the electrical activity in your heart which can be seen on an electrocardiogram (EKG). These changes can lead to a dangerous abnormal heartbeat. Taking Tetrabenazine tablet with certain medicines may increase this chance.
  • Dizziness due to blood pressure changes when you change position (orthostatic hypotension). Change positions slowly from lying down to sitting up and from sitting up to standing when taking Tetrabenazine tablet. Tell your doctor right away if you get dizzy or faint while taking Tetrabenazine tablet. Your doctor may need to watch your blood pressure closely.

Common side effects with TETRABENAZINE include:

  • sleepiness (sedation)
  • trouble sleeping
  • depression
  • tiredness (fatigue)
  • anxiety
  • restlessness
  • agitation
  • nausea

Tell your doctor if you have any side effects. Do not stop taking Tetrabenazine tablet without talking to your doctor first.

Call your doctor for medical advice about side effects. You may report side effects to the Food and Drug Administration (FDA) at 1-800-FDA-1088.

General information about Tetrabenazine tablet

Tetrabenazine tablet contains the active ingredient tetrabenazine. It also contains these inactive ingredients: lactose, maize starch, talc, and magnesium stearate. The 25 mg tablet, which is pale yellow, also contains yellow iron oxide.

Medicines are sometimes prescribed for conditions that are not listed in a Medication Guide. Do not use Tetrabenazine tablet for a condition for which it was not prescribed. Do not give Tetrabenazine tablet to other people, even if they have the same symptoms that you have. It may harm them. Keep Tetrabenazine tablet out of the reach of children.

This Medication Guide summarizes the most important information about Tetrabenazine tablet. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information about Tetrabenazine tablet that is written for healthcare professionals.

You can also call Tagi Pharma at 1-844-870-7759 or visit www.tagipharma.com.

Trademarks are property of their respective owners.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Manufactured For:

TAGI Pharma, Inc.
722 Progressive Lane,
Room 205
South Beloit, IL 61080

Revised: 01/2018

Revised: 1/2019
TAGI Pharma, Inc.