MORPHINE SULFATE- morphine sulfate capsule, extended release 
Upsher-Smith Laboratories, LLC

----------

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Medication Guide
Morphine Sulfate (mor∙feen sul∙fate) Extended-Release Capsules, CII

Morphine sulfate extended-release capsules are:

  • A strong prescription pain medicine that contains an opioid (narcotic) that is used to manage pain severe enough to require daily around-the-clock, long-term treatment with an opioid, when other pain treatments such as non-opioid pain medicines or immediate-release opioid medicines do not treat your pain well enough or you cannot tolerate them.
  • A long-acting (extended-release) opioid pain medicine that can put you at risk for overdose and death. Even if you take your dose correctly as prescribed you are at risk for opioid addiction, abuse, and misuse that can lead to death.
  • Not for use to treat pain that is not around-the-clock.

Important information about morphine sulfate extended-release capsules:

  • Get emergency help right away if you take too much morphine sulfate extended-release capsules (overdose). When you first start taking morphine sulfate extended-release capsules, when your dose is changed, or if you take too much (overdose), serious or life-threatening breathing problems that can lead to death may occur.
  • Taking morphine sulfate extended-release capsules with other opioid medicines, benzodiazepines, alcohol, or other central nervous system depressants (including street drugs) can cause severe drowsiness, decreased awareness, breathing problems, coma, and death.
  • Never give anyone else your morphine sulfate extended-release capsules. They could die from taking it. Store morphine sulfate extended-release capsules away from children and in a safe place to prevent stealing or abuse. Selling or giving away morphine sulfate extended-release capsules is against the law.

Do not take morphine sulfate extended-release capsules if you have:

  • severe asthma, trouble breathing, or other lung problems.
  • a bowel blockage or have narrowing of the stomach or intestines.

Before taking morphine sulfate extended-release capsules, tell your healthcare provider if you have a history of:

  • head injury, seizures
  • problems urinating
  • liver, kidney, thyroid problems
  • pancreas or gallbladder problems
  • abuse of street or prescription drugs, alcohol addiction, or mental health problems.

Tell your healthcare provider if you are:

  • pregnant or planning to become pregnant. Prolonged use of morphine sulfate extended-release capsules during pregnancy can cause withdrawal symptoms in your newborn baby that could be life-threatening if not recognized and treated.
  • breastfeeding. Not recommended during treatment with morphine sulfate extended-release capsules. It may harm your baby.
  • taking prescription or over-the-counter medicines, vitamins, or herbal supplements. Taking morphine sulfate extended-release capsules with certain other medicines can cause serious side effects.

When taking morphine sulfate extended-release capsules:

  • Do not change your dose. Take morphine sulfate extended-release capsules exactly as prescribed by your healthcare provider. Use the lowest dose possible for the shortest time needed.
  • Take your prescribed dose every 12 or 24 hours at the same time every day. Do not take more than your prescribed dose in 24 hours. If you miss a dose, take your next dose at your usual time.
  • Swallow morphine sulfate extended-release capsules whole. Do not cut, break, chew, crush, dissolve, snort, or inject morphine sulfate extended-release capsules because this may cause you to overdose and die.
  • You should not receive morphine sulfate extended-release capsules through a nasogastric tube.
  • If you cannot swallow morphine sulfate extended-release capsules, see the detailed Instructions For Use.
  • Call your healthcare provider if the dose you are taking does not control your pain.
  • Do not stop taking morphine sulfate extended-release capsules without talking to your healthcare provider.
  • After you stop taking morphine sulfate extended-release capsules, flush any unused capsules down the toilet.

While taking morphine sulfate extended-release capsules DO NOT:

  • Drive or operate heavy machinery, until you know how morphine sulfate extended-release capsules affects you. Morphine sulfate extended-release capsules can make you sleepy, dizzy, or lightheaded.
  • Drink alcohol or use prescription or over-the-counter medicines that contain alcohol. Using products containing alcohol during treatment with morphine sulfate extended-release capsules may cause you to overdose and die.

The possible side effects of morphine sulfate extended-release capsules are:

  • constipation, nausea, sleepiness, vomiting, tiredness, headache, dizziness, abdominal pain. Call your healthcare provider if you have any of these symptoms and they are severe.

Get emergency medical help if you have:

  • trouble breathing, shortness of breath, fast heartbeat, chest pain, swelling of your face, tongue, or throat, extreme drowsiness, light-headedness when changing positions, feeling faint, agitation, high body temperature, trouble walking, stiff muscles, or mental changes such as confusion.

These are not all the possible side effects of morphine sulfate extended-release capsules. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. For more information go to dailymed.nlm.nih.gov

For Medication Guides, please visit www.upsher-smith.com or call 1-888-650-3789.

Manufactured by
UPSHER-SMITH LABORATORIES, LLC
Maple Grove, MN 55369

Revised 0119

Revised: 1/2019
Upsher-Smith Laboratories, LLC