KRYSTEXXA- pegloticase injection, solution 
Horizon Therapeutics USA, Inc.


Medication Guide
injection, for intravenous use

Read this Medication Guide before you start receiving KRYSTEXXA and before each treatment. There may be new information. This Medication Guide does not take the place of talking with your doctor about your medical condition or treatment. Talk to your doctor if you have any questions about your treatment with KRYSTEXXA.

What is the most important information I should know about KRYSTEXXA?

Serious allergic reactions may happen in some people who receive KRYSTEXXA. These allergic reactions can be life threatening and usually happen within 2 hours of the infusion.

KRYSTEXXA should be given to you by a doctor or nurse in a healthcare setting where serious allergic reactions can be treated. Your doctor or nurse should watch you for any signs of a serious allergic reaction during and after your treatment with KRYSTEXXA.

Tell your doctor or nurse right away if you have any of these symptoms during or after your treatment with KRYSTEXXA:


It is not known if KRYSTEXXA is safe and effective in children under 18 years of age.

Who should not receive KRYSTEXXA?

Do not receive KRYSTEXXA if you:

What should I tell my doctor before receiving treatment with KRYSTEXXA?

Before you receive KRYSTEXXA, tell your doctor about all of your medical conditions, including if you:

Tell your doctor about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Do not take any other uric acid lowering drug, such as allopurinol, febuxostat (Uloric) or probenecid, while receiving KRYSTEXXA.

Know the medicines you take. Keep a list of your medicines and show them to your doctor and pharmacist when you get a new medicine.

How will I receive KRYSTEXXA?

What are the possible side effects of KRYSTEXXA?

KRYSTEXXA may cause serious side effects.

See "What is the most important information I should know about KRYSTEXXA?"

The most common side effects of KRYSTEXXA when given together with methotrexate include:

The most common side effects of KRYSTEXXA include:

Tell your doctor if you have any side effect that bothers you or that does not go away.

These are not all of the side effects of KRYSTEXXA. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

You may also report side effects to Horizon at 1-866-479-6742.

General information about the safe and effective use of KRYSTEXXA.

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. This Medication Guide summarizes the most important information about KRYSTEXXA. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information about KRYSTEXXA that is written for health professionals.

For more information, go to or call 1-866-479-6742.

What are the ingredients in KRYSTEXXA?

Active ingredient: pegloticase

Inactive ingredients: disodium hydrogen phosphate dihydrate, sodium chloride, sodium dihydrogen phosphate dihydrate, and water for injection.

Product manufactured by:
Horizon Therapeutics Ireland DAC
Dublin, Ireland
US License Number 2022

Product distributed by:
Horizon Therapeutics USA, Inc.
Deerfield, IL 60015

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Revised: 7/2022


Revised: 12/2022
Horizon Therapeutics USA, Inc.