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Medication Guide for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

NSAIDs can cause serious side effects, including:

Do not take NSAIDs right before or after a heart surgery called a "coronary artery bypass graft (CABG)."

Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.

The risk of getting an ulcer or bleeding increases with:

•   past history of stomach ulcers,                                                   •   increasing doses of NSAIDs
    or stomach or intestinal                                                               •   longer use of NSAIDS
    bleeding with the use of                                                              •   smoking
    NSAIDs                                                                                       •   drinking alcohol
•   taking medicines called                                                              •   older age
    "corticosteroids",                                                                        •   poor health
    "anticoagulants", "SSRIs", or                                                     •   advanced liver disease
    "SNRIs"                                                                                      •   bleeding problems

NSAIDs should only be used:

What are NSAIDs?

NSAIDs are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as different types of arthritis, menstrual cramps, and other types of short-term pain.

Who should not take NSAIDs?

Do not take NSAIDs:

Before taking NSAIDs, tell your healthcare provider about all of your medical conditions, including if you:

Tell your healthcare provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. NSAIDs and some other medicines can interact with each other and cause serious side effects. Do not start taking any new medicine without talking to your healthcare provider first.

What are the possible side effects of NSAIDs?
NSAIDs can cause serious side effects, including:

See "What is the most important information I should know about medicines called NonSteroidal Anti-inflammatory Drugs (NSAIDs)?"

Get emergency help right away if you get any of the following symptoms:

Stop taking your NSAID and call your healthcare provider right away if you get any of the following symptoms:

•   nausea                                                             •   vomit blood
•   more tired or weaker than usual                     •   there is blood in your bowel movement
•   diarrhea                                                               or it is black and sticky like tar
•   itching                                                             •   unusual weight gain
•   your skin or eyes look yellow                         •   skin rash or blisters with fever
•   indigestion or stomach pain                            •   swelling of the arms and legs, hands and
•   flu-like symptoms                                               feet

If you take too much of your NSAID, call your healthcare provider or get medical help right away.

These are not all the possible side effects of NSAIDs. For more information, ask your pharmacist about NSAIDs.

Call your doctor for medical advice about side effects. You may report side effects to FDA at

Other information about NSAIDs

General information about the safe and effective use of NSAIDs

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use NSAIDs for a condition for which it was not prescribed. Do not give NSAIDs to other people, even if they have the same symptoms that you have. It may harm them.

If you would like more information about NSAIDs, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about NSAIDs that is written for health professionals.

For more information go to or call 1-800-615-0187.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

Revised: 7/2015

Hospira, Inc., Lake Forest, IL 60045 USA                                                                                  Hospira logo

Revised: 1/2020
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