NABUMETONE- nabumetone tablet, film coated 
NCS HealthCare of KY, LLC dba Vangard Labs

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MEDICATION GUIDE FOR NON-STEROIDAL ANTI-INFLAMMATORY DRUGS (NSAIDS)

(See the end of this Medication Guide for a list of prescription NSAID medicines.)

What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

NSAIDmedicines may increase the chance of a heart attack or stroke that can lead to death.This chance increases:

  • with longer use of NSAID medicines
  • in people who have heart disease

NSAID medicines should never be used right before or after a heart surgery called a “coronary artery bypass graft (CABG).”

NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment.

Ulcers and bleeding:

  • can happen without warning symptoms
  • may cause death

The chance of a person getting an ulcer or bleeding increases with:

  • taking medicines called “corticosteroids” and “anticoagulants”
  • longer use
  • smoking
  • drinking alcohol
  • older age
  • having poor health

NSAID medicines should only be used:

  • exactly as prescribed
  • at the lowest dose possible for your treatment
  • for the shortest time needed

 What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

NSAID medicines are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as:

  • different types of arthritis
  • menstrual cramps and other types of short-term pain

Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAIDs)?

Do not take an NSAID medicine:

  • if you had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAID medicine
  • for pain right before or after heart bypass surgery

Tell your healthcare provider:

  • about all of your medical conditions.
  • about all of the medicines you take. NSAIDs and some other medicines can interact with each other and cause serious side effects. Keep a list of your medicines to show to your healthcare provider and pharmacist.
  • if you are pregnant. NSAID medicines should not be used by pregnant women late in their pregnancy.
  • if you are breastfeeding. Talk to your doctor.

What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

 Serious side effects include: Other side effects include:
 • heart attack  • stomach pain
 • stroke  • constipation
 • high blood pressure  • diarrhea
 • heart failure from body swelling (fluid retention)  • gas
 • kidney problems including kidney failure  • heartburn
 • bleeding and ulcers in the stomach and intestine  • nausea
 • low red blood cells (anemia)  • vomiting
 • life-threatening skin reactions  • dizziness
 • life-threatening allergic reactions  
 • liver problems including liver failure  
 • asthma attacks in people who have asthma  

Get emergency help right away if you have any of the following symptoms:

 • shortness of breath or trouble breathing  • slurred speech
 • chest pain  • swelling of the face or throat
 • weakness in one part or side of your body   

Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:

 • nausea  • vomit blood
 • more tired or weaker than usual  • there is blood in your bowel movement
 • itching   or it is black and sticky like tar
 • your skin or eyes look yellow  • unusual weight gain
 • stomach pain  • skin rash or blisters with fever
 • flu-like symptoms  • swelling of the arms and legs, hands and feet

These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines.

Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

  • Aspirin is an NSAID medicine but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.
  • Some of these NSAID medicines are sold in lower doses without a prescription (over-the-counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.

NSAID medicines that need a prescription

 
 Generic Name Tradename
  Celecoxib   Celebrex
  Diclofenac   Cataflam, Voltaren, Arthrotec (combined with misoprostol)
  Diflunisal   Dolobid
  Etodolac   Lodine, Lodine XL
  Fenoprofen   Nalfon, Nalfon 200
  Flurbiprofen   Ansaid
  Ibuprofen   Motrin, Tab-Profen, Vicoprofen* (combined with hydrocodone), Combunox (combined with oxycodone)
  Indomethacin   Indocin, Indocin SR, Indo-Lemmon, Indomethagan
  Ketoprofen   Oruvail
  Ketorolac   Toradol
  Mefenamic Acid   Ponstel
  Meloxicam   Mobic
  Nabumetone   Relafen
  Naproxen   Naprosyn, Anaprox, Anaprox DS, EC-Naproxyn, Naprelan, Naprapac (copackaged with lansoprazole)
  Oxaprozin   Daypro
  Piroxicam   Feldene
  Sulindac  Clinoril
  Tolmetin   Tolectin, Tolectin DS, Tolectin 600

This Medication Guide has been approved by the U.S. Food and Drug Administration. 1-800-828-9393

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Distributed by:

Par Pharmaceutical Companies, Inc.

Spring Valley, NY 10977

  
  Rev: l11/09   OS195-01-71-01
  
Revised: 5/2011
Document Id: 1148ae8d-cbae-4495-a346-ff5921e2a33a
Set id: 62eba9b3-c088-4638-8683-07387b336399
Version: 14
Effective Time: 20110523
NCS HealthCare of KY, LLC dba Vangard Labs