NAPROXEN- naproxen tablet 
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Medication Guide for Non-steroidal Anti-Inflammatory Drugs (NSAIDs)

(See the end of this Medication Guide for a list of prescription NSAID medicines.)

What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?
NSAID medicines may increase the chance of a heart attack or stroke that can lead to death. This chance increases:

NSAID medicines should never be used right before or after a heart surgery called a "coronary artery bypass graft (CABG)."

NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding:

The chance of a person getting an ulcer or bleeding increases with:

NSAID medicines should only be used:

What are Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

NSAID medicines are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as:

Who should not take a Non-Steroidal Anti-Inflammatory Drug (NSAID)?
Do not take an NSAID medicine:

Tell your healthcare provider:

What are the possible side effects of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?


Serious side effects include:


Other side effects include:

  • heart attack 
  • stroke
  • high blood pressure
  • heart failure from body swelling (fluid
  • kidney problems including kidney
  • bleeding and ulcers in the stomach and
  • low red blood cells (anemia) 
  • life-threatening skin reactions 
  • life-threatening allergic reactions 
  • liver problems including liver failure 
  • asthma attacks in people who have
  • stomach pain 
  • constipation
  • diarrhea
  • gas 
  • heartburn
  • nausea
  • vomiting
  • dizziness
Get emergency help right away if you have any of the following symptoms:
  • shortness of breath or trouble
  • chest pain
  • weakness in one part or side of your body
  • slurred speech
  • swelling of the face or
Stop your NSAID medicine and call your healthcare provider right away if you have any of the following symptoms:
  • nausea
  • more tired or weaker than usual
  • itching
  • your skin or eyes look yellow
  • stomach pain
  • flu-like symptoms
  • vomit blood
  • there is blood in your bowel
    movement or it is black and sticky 
    like tar
  • unusual weight gain
  • skin rash or blisters with fever
  • swelling of the arms and legs,
    hands and feet

These are not all the side effects with NSAID medicines. Talk to your healthcare provider or pharmacist for more information about NSAID medicines.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or West-ward at 1-877-233-2001.

Other information about Non-Steroidal Anti-Inflammatory Drugs (NSAIDs):

NSAID medicines that need a prescription

Generic Name



  Cataflam®, Voltaren®, ArthrotecTM (combined with misoprostol) 
  Lodine®, Lodine®XL 
  Nalfon®, Nalfon200®
  Motrin®, Tab-Profen®, Vicoprofen®* (combined with hydrocodone), 
CombunoxTM (combined with oxycodone) 
  Indocin®, Indocin®SR, Indo-LemmonTM, IndomethaganTM
  Mefenamic Acid
  Naprosyn®, Anaprox®, Anaprox®DS, EC-Naprosyn®, Naprelan®
Naprapac® (copackaged with lansoprazole) 
  Tolectin®, Tolectin DS®, Tolectin®600 

*Vicoprofen contains the same dose of ibuprofen as over-the-counter (OTC) NSAIDs, and is usually used for less than 10 days to treat pain.  The OTC NSAID label warns that long term continuous use may increase the risk of heart attack or stroke.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

All registered trademarks in this document are the property of their respective owners.

Distributed by:
Major Pharmaceuticals
Livonia, MI 48150  USA

Revised September 2009

Revised: 7/2014
Aphena Pharma Solutions - Tennessee, LLC