ETHOSUXIMIDE- ethosuximide solution 
Greenstone LLC




Capsules, Oral Solution

Read this Medication Guide before you start taking ethosuximide and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment. If you have any questions about ethosuximide, ask your healthcare provider or pharmacist.

What is the most important information I should know about ethosuximide?

Do not stop taking ethosuximide without first talking to your healthcare provider. Stopping ethosuximide suddenly can cause serious problems.

Ethosuximide can cause serious side effects, including:

Rare but serious blood problems that may be life-threatening. Call your healthcare provider right away if you have:
  • fever, swollen glands, or sore throat that come and go or do not go away
  • frequent infections or an infection that does not go away
  • easy bruising
  • red or purple spots on your body
  • bleeding gums or nose bleeds
  • severe fatigue or weakness
Drug reactions that may affect different parts of the body such as your liver, kidneys, heart, or blood cells. You may or may not have a rash with these types of reactions. These reactions can be very serious and can cause death. Call your healthcare provider right away if you have any of these symptoms:
  • joint pain and swelling
  • muscle pain
  • fatigue, weakness
  • low-grade fever
  • pain in the chest that is worse with breathing
  • skin rash
  • swollen lymph glands
  • swelling of your face
  • yellowing of your skin or the white part of your eyes
Like other antiepileptic drugs, ethosuximide may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

  • thoughts about suicide or dying
  • attempts to commit suicide
  • new or worse depression
  • new or worse anxiety
  • feeling agitated or restless
  • panic attacks
  • trouble sleeping (insomnia)
  • new or worse irritability
  • acting aggressive, being angry, or violent
  • acting on dangerous impulses
  • an extreme increase in activity and talking (mania)
  • other unusual changes in behavior or mood

How can I watch for early symptoms of suicidal thoughts and actions?

  • Pay attention to any changes, especially sudden changes, in mood, behaviors, thoughts, or feelings.
  • Keep all follow-up visits with your healthcare provider as scheduled.

Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Do not stop ethosuximide without first talking to a healthcare provider.

  • Stopping ethosuximide suddenly can cause serious problems.
  • Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop (status epilepticus).

Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

What is ethosuximide?

Ethosuximide is a prescription medicine used to treat absence (petit mal) seizures.

Who should not take ethosuximide?

Do not take ethosuximide if you are allergic to succinimides (methsuximide or ethosuximide), or any of the ingredients in ethosuximide. See the end of this Medication Guide for a complete list of ingredients in ethosuximide.

What should I tell my healthcare provider before taking ethosuximide?

Before you take ethosuximide, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Taking ethosuximide with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them with you to show your healthcare provider and pharmacist when you get a new medicine.

How should I take ethosuximide?

What should I avoid while taking ethosuximide?

What are the possible side effects of ethosuximide?

Ethosuximide may cause other serious side effects, including:

Call your healthcare provider right away, if you have any of the symptoms listed above.

The most common side effects of ethosuximide include

  • nausea or vomiting
  • indigestion, stomach pain
  • diarrhea
  • weight loss
  • loss of appetite
  • hiccups
  • fatigue
  • dizziness or lightheadedness
  • unsteadiness when walking
  • headache
  • loss of concentration

Tell your healthcare provider about any side effect that bothers you or that does not go away.

These are not all the possible side effects with ethosuximide. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store ethosuximide?

Keep ethosuximide and all medicines out of the reach of children.

General information about ethosuximide

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use ethosuximide for a condition for which it was not prescribed. Do not give ethosuximide to other people, even if they have the same condition. It may harm them.

This Medication Guide summarizes the most important information about ethosuximide. If you would like more information, talk with your healthcare provider. You can ask your healthcare provider or pharmacist for information about ethosuximide that is written for healthcare professionals.

For more information, go to or call 1-800-438-1985.

What are the ingredients in ethosuximide?

Active ingredient: ethosuximide


Inactive ingredients: Polyethylene glycol 400, NF; D&C yellow No. 10; FD&C red No. 3; gelatin, NF; glycerin, USP; and sorbitol.

Oral Solution

Inactive ingredients: Each 5 ml (teaspoonful) of oral solution contains 250 mg ethosuximide in a raspberry flavored base. Also contains citric acid, anhydrous, USP; FD&C red No. 40; FD&C yellow No. 6; flavor; glycerin, USP; purified water, USP; saccharin sodium, USP; sodium benzoate, NF; Sodium Citrate, USP; sucrose, NF.

This Medication Guide has been approved by the U.S. Food and Drug Administration.


May 2016

Revised: 6/2022
Greenstone LLC