DEPAKOTE ER- divalproex sodium tablet, extended release 
AbbVie Inc.

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MEDICATION GUIDE

DEPAKOTE ER (dep-a-kOte)
(divalproex sodium)
Extended-Release Tablets

DEPAKOTE (dep-a-kOte)
(divalproex sodium)
Tablets

DEPAKOTE (dep-a-kOte)
(divalproex sodium delayed release capsules)
Sprinkle Capsules

Read this Medication Guide before you start taking Depakote and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

What is the most important information I should know about Depakote?

Do not stop taking Depakote without first talking to your healthcare provider.

Stopping Depakote suddenly can cause serious problems.

Depakote can cause serious side effects, including:

1. Serious liver damage that can cause death, especially in children younger than 2 years old. The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment.

Call your healthcare provider right away if you get any of the following symptoms:

In some cases, liver damage may continue despite stopping the drug.

2. Depakote may harm your unborn baby.

3. Inflammation of your pancreas that can cause death.

Call your healthcare provider right away if you have any of these symptoms:

4. Like other antiepileptic drugs, Depakote may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

How can I watch for early symptoms of suicidal thoughts and actions?

Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Do not stop Depakote without first talking to a healthcare provider. Stopping Depakote suddenly can cause serious problems. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop (status epilepticus).

Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

What is Depakote?

Depakote comes in different dosage forms with different usages.

Depakote Tablets and Depakote Extended-Release Tablets are prescription medicines used:

Depakote Sprinkle Capsules is a prescription medicine used alone or with other medicines, to treat:

Who should not take Depakote?

Do not take Depakote if you:

What should I tell my healthcare provider before taking Depakote?

Before you take Depakote, tell your healthcare provider if you:

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, herbal supplements and medicines that you take for a short period of time.

Taking Depakote with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist each time you get a new medicine.

How should I take Depakote?

What should I avoid while taking Depakote?

What are the possible side effects of Depakote?

Depakote can cause serious side effects including:

Call your healthcare provider right away, if you have any of the symptoms listed above.

The common side effects of Depakote include:

These are not all of the possible side effects of Depakote. For more information, ask your healthcare provider or pharmacist.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Depakote?

Keep Depakote and all medicines out of the reach of children.

General information about the safe and effective use of Depakote

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Depakote for a condition for which it was not prescribed. Do not give Depakote to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Depakote. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Depakote that is written for health professionals.

For more information, go to www.rxabbvie.com or call 1-800-633-9110.

What are the ingredients in Depakote?

Active ingredient: divalproex sodium

Inactive ingredients:

Depakote ER:
     250 mg is Mfd. by AbbVie LTD, Barceloneta, PR 00617
     500 mg is Mfd. by AbbVie Inc., North Chicago, IL 60064 U.S.A. or
     AbbVie LTD, Barceloneta, PR 00617
     For AbbVie Inc., North Chicago, IL 60064 U.S.A.

Depakote Tablets:
     Mfd. by AbbVie LTD, Barceloneta, PR 00617
     For AbbVie Inc., North Chicago, IL 60064, U.S.A.

Depakote Sprinkle Capsules:
     AbbVie Inc., North Chicago, IL 60064, U.S.A.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

©2000-2021 AbbVie Inc.

Revised: June 2021 

20068448 

Revised: 6/2021
AbbVie Inc.