DEPAKOTE- divalproex sodium tablet, delayed release 
AbbVie Inc.



DEPAKOTE ER (dep-a-kOte)
(divalproex sodium)
Extended-Release Tablets, for oral use 

DEPAKOTE (dep-a-kOte)
(divalproex sodium)
Delayed-Release Tablets, for oral use 

DEPAKOTE Sprinkle Capsules (dep-a-kOte)
(divalproex sodium delayed release capsules)
for oral use

What is the most important information I should know about DEPAKOTE?

Do not stop Depakote without first talking to a healthcare provider. Stopping Depakote suddenly can cause serious problems. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that will not stop (status epilepticus).

Depakote can cause serious side effects, including:

1. Serious liver damage that can cause death, especially in children younger than 2 years old and patients with mitochondrial disorders. The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment.

Call your healthcare provider right away if you get any of the following symptoms:

In some cases, liver damage may continue even though the medicine is stopped. Your healthcare provider will do blood tests to check your liver before and during treatment with DEPAKOTE.

2. Depakote may harm your unborn baby.

3. Swelling (Inflammation) and bleeding (hemorrhaging) of your pancreas that can cause death.

Call your healthcare provider right away if you have any of these symptoms:

4. Like other antiepileptic drugs, Depakote may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

How can I watch for early symptoms of suicidal thoughts and actions?

Call your healthcare provider between visits as needed, especially if you are worried about symptoms.

Suicidal thoughts or actions can be caused by things other than medicines. If you have suicidal thoughts or actions, your healthcare provider may check for other causes.

What is Depakote?

Depakote ER tablets, Depakote delayed-release tablets, and Depakote Sprinkle Capsules are prescription medicines used:

Depakote ER tablets and Depakote delayed-release tablets are also used to prevent migraine headaches.

Depakote ER tablets are also used to treat acute manic or mixed episodes associated with bipolar disorder with or without psychotic features.

Depakote delayed-release tablets are also used to treat manic episodes associated with bipolar disorder.

Do not take Depakote if you:

Before taking Depakote, tell your healthcare provider about all of your medical conditions including if you:

Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. 

DEPAKOTE may affect the way other medicines work, and other medicines may affect how DEPAKOTE works. Using DEPAKOTE with other medicines can cause serious side effects. Do not start or stop other medicines without talking to your healthcare provider.

Especially tell your healthcare provider if you take:

You can ask your healthcare provider or pharmacist for a list of these medicines if you are not sure.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist each time you get a new medicine.  

How should I take Depakote?

What should I avoid while taking Depakote?

What are the possible side effects of Depakote?

Call your healthcare provider right away if you have any of the symptoms listed below. Your healthcare provider may do additional tests before and during your treatment with DEPAKOTE. Your healthcare provider may reduce your dose, temporarily stop, or permanently stop treatment if you have certain side effects.

Depakote can cause serious side effects including:

○ bruising or red or purple spots on your skin○ vomiting blood or vomit that looks like coffee grounds
○ bleeding from your mouth or nose○ blood in your stools or black stools (looks like tar)
○ cough up blood or blood clots○ pain and swelling in your joints
○ feeling tired○ drowsiness
○ confusion○ coma
○ memory loss○ shivering
○ fever○ blistering and peeling of your skin
○ skin rash○ swelling of your lymph nodes
○ hives○ swelling of your face, eyes, lips, tongue, or throat
○ sores in your mouth,○ trouble swallowing or breathing

The common side effects of DEPAKOTE include:

• headache• loss of appetite
• weakness• weight loss
• sleepiness• increased appetite
• dizziness• weight gain
• tremors• nausea / vomiting
• difficulty walking or problems with coordination• stomach pain
• ringing in your ears• diarrhea
• blurred vision• constipation
• double vision• bronchitis
• unusual eye movement• flu-like symptoms
• hair loss (alopecia)• infection
• swelling of your arms or legs

These are not all of the possible side effects of Depakote.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Depakote?

Keep Depakote and all medicines out of the reach of children.

General information about the safe and effective use of Depakote

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Depakote for a condition for which it was not prescribed. Do not give Depakote to other people, even if they have the same symptoms that you have. It may harm them.

You can ask your pharmacist or healthcare provider for information about Depakote that is written for health professionals.

What are the ingredients in Depakote?

Active ingredient: divalproex sodium

Inactive ingredients:

Manufactured by:

Depakote ER tablets:
     250 mg is Mfd. by AbbVie LTD, Barceloneta, PR 00617
     500 mg is Mfd. by AbbVie Inc., North Chicago, IL 60064 U.S.A. or
     AbbVie LTD, Barceloneta, PR 00617
     For AbbVie Inc., North Chicago, IL 60064 U.S.A.

Depakote delayed-release tablets:
     Mfd. by AbbVie LTD, Barceloneta, PR 00617
     For AbbVie Inc., North Chicago, IL 60064, U.S.A.

Depakote Sprinkle Capsules:
     AbbVie Inc., North Chicago, IL 60064, U.S.A.

For more information, go to or call 1-800-633-9110.

This Medication Guide has been approved by the U.S. Food and Drug Administration.

©1983-2023 AbbVie Inc.

Revised: February 2023


Revised: 2/2023
AbbVie Inc.