Medication Guide for Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) 

What is the most important information I should know about medicines called Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)?

NSAIDs can cause serious side effects, including:

Increased risk of a heart attack or stroke that can lead to death. This risk may happen early in treatment and may increase:

 

with increasing doses of NSAIDs

 

with longer use of NSAIDs

Do not take NSAIDs right before or after a heart surgery called a “coronary artery bypass graft (CABG)”. Avoid taking NSAIDs after a recent heart attack, unless your healthcare provider tells you to. You may have an increased risk of another heart attack if you take NSAIDs after a recent heart attack.  

1.

Increased risk of bleeding, ulcers, and tears (perforation) of the esophagus (tube leading from the mouth to the stomach), stomach and intestines:

 

anytime during use

 

without warning symptoms

 

that may cause death

The risk of getting an ulcer or bleeding increases with:

 

past history of stomach ulcers, or stomach or intestinal bleeding with use of NSAIDs

 

taking medicines called “corticosteroids”, “anticoagulants”, “SSRIs”, “SNRIs” increasing doses of NSAIDs

 

longer use of NSAIDs

 

smoking

 

drinking alcohol

 

older age

 

poor health

 

advanced liver disease

 

bleeding problems

NSAIDs should only be used:

 

exactly as prescribed

 

at the lowest dose possible

 

for your treatment for the shortest time needed

What are NSAIDs?

NSAIDs are used to treat pain and redness, swelling, and heat (inflammation) from medical conditions such as different types of arthritis, menstrual cramps, and other types of short-term pain.  

Who should not take NSAIDs?

Do not take NSAIDs:

 

if you have had an asthma attack, hives, or other allergic reaction with aspirin or any other NSAIDs.

 

right before or after heart bypass surgery.  

Before taking NSAIDs, tell your healthcare provider about all of your medical conditions, including if you:

 

have liver or kidney problems

 

have high blood pressure

 

have asthma are pregnant or plan to become pregnant. Talk to your healthcare provider if you are considering taking NSAIDs during pregnancy. You should not take NSAIDs after 29 weeks of pregnancy.

 

are breastfeeding or plan to breastfeed.  

Tell your healthcare provider about all of the medicines you take, including prescription or over-the-counter medicines, vitamins or herbal supplements. NSAIDs and some other medicines can interact with each other and cause serious side effects. Do not start taking any new medicine without talking to your healthcare provider first.  

What are the possible side effects of NSAIDs?

NSAIDs can cause serious side effects, including: See “What is the most important information I should know about medicines called Nonsteroidal Anti-inflammatory Drugs (NSAIDs)?”

1.

new or worse high blood pressure

2.

heart failure

3.

liver problems including liver failure

4.

kidney problems including kidney failure

5.

low red blood cells (anemia)

6.

life-threatening skin reactions

7.

life-threatening allergic reactions

8.

Other side effects of NSAIDs include: stomach pain, constipation, diarrhea, gas, heartburn, nausea, vomiting, and dizziness.

Get emergency help right away if you have any of the following symptoms:

 

shortness of breath or trouble breathing

 

chest pain

 

weakness in one part or side of your body

 

slurred speech

 

swelling of the face or throat

Stop taking your NSAID and call your healthcare provider right away if you get any of the following symptoms:

 

nausea

 

more tired or weaker than usual

 

diarrhea

 

itching

 

your skin or eyes look yellow

 

indigestion or stomach pain

 

flu-like symptoms

 

vomit blood

 

there is blood in your bowel movement or it is black and sticky like tar

 

unusual weight gain

 

skin rash or blisters with fever

 

swelling of the arms and legs, hands and feet

If you take too much of your NSAID, call your healthcare provider or get medical help right away.  

These are not all the possible side effects of NSAIDs. For more information, ask your healthcare provider or pharmacist about NSAIDs.  

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.  

Other information about NSAIDs

1.

Aspirin is an NSAID but it does not increase the chance of a heart attack. Aspirin can cause bleeding in the brain, stomach, and intestines. Aspirin can also cause ulcers in the stomach and intestines.

2.

Some NSAIDs are sold in lower doses without a prescription (over-the-counter). Talk to your healthcare provider before using over-the-counter NSAIDs for more than 10 days.  

General information about the safe and effective use of NSAIDs

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use NSAIDs for a condition for which it was not prescribed. Do not give NSAIDs to other people, even if they have the same symptoms that you have. It may harm them.

If you would like more information about NSAIDs, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about NSAIDs that is written for health professionals. 

This Medication Guide has been approved by the U.S. Food and Drug Administration. 

To reorder additional Medication Guides, please contact Dr. Reddy's Customer Service at 1-866-733-3952.

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Revised: 0616

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