MEDROXYPROGESTERONE ACETATE- medroxyprogesterone acetate tablet 
Cardinal Health

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Medroxyprogesterone Acetate Tablets, USP

DESCRIPTION

Medroxyprogesterone acetate tablets contain medroxyprogesterone acetate, which is a derivative of progesterone. It is a white to off-white, odorless crystalline powder, stable in air, melting between 200 and 210°C. It is freely soluble in chloroform, soluble in acetone and in dioxane, sparingly soluble in alcohol and in methanol, slightly soluble in ether, and insoluble in water.

The chemical name for medroxyprogesterone acetate is Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6α)-. The structural formula is:

Chemical Structure

Each tablet for oral administration contains 2.5 mg, 5 mg or 10 mg of medroxyprogesterone acetate.

Inactive ingredients: calcium stearate, corn starch, lactose, mineral oil, sorbic acid, sucrose, talc. The 2.5 mg tablet contains FD&C Yellow No. 6.

CLINICAL PHARMACOLOGY

Medroxyprogesterone acetate, administered orally or parenterally in the recommended doses to women with adequate endogenous estrogen, transforms proliferative into secretory endometrium. Androgenic and anabolic effects have been noted, but the drug is apparently devoid of significant estrogenic activity. While parenterally administered medroxyprogesterone acetate inhibits gonadotropin production, which in turn prevents follicular maturation and ovulation, available data indicate that this does not occur when the usually recommended oral dosage is given as single daily doses.

Pharmacokinetics

The pharmacokinetics of medroxyprogesterone acetate were determined in 20 postmenopausal women following a single-dose administration of eight medroxyprogesterone acetate tablets 2.5 mg or a single administration of two medroxyprogesterone acetate tablets 10 mg under fasting conditions. In another study, the steady-state pharmacokinetics of medroxyprogesterone acetate were determined under fasting conditions in 30 postmenopausal women following daily administration of one medroxyprogesterone acetate tablet 10 mg for 7 days. In both studies, medroxyprogesterone acetate was quantitated in serum using a validated gas chromatography-mass spectrometry (GC-MS) method. Estimates of the pharmacokinetic parameters of medroxyprogesterone acetate after single and multiple doses of medroxyprogesterone acetate tablets were highly variable and are summarized in Table 1.

Table 1. Mean (SD) Pharmacokinetic Parameters for Medroxyprogesterone Acetate Tablets
Tablet Strength C max
(ng/mL)
T max
(h)
Auc 0–(∞)
(ng∙h/mL)
t 1/2
(h)
Vd/f
(L)
CL/f
(mL/min)
*
Following Day 7 dose

Single Dose

2 × 10 mg

1.01 (0.599)

2.65 (1.41)

6.95 (3.39)

12.1 (3.49)

78024
(47220)

64110
(42662)

8 × 2.5 mg

0.805 (0.413)

2.22 (1.39)

5.62 (2.79)

11.6 (2.81)

62748
(40146)

74123
(35126)

Multiple Dose

10 mg *

0.71 (0.35)

2.83 (1.83)

6.01 (3.16)

16.6 (15.0)

40564
(38256)

41963
(38402)

Absorption: No specific investigation on the absolute bioavailability of medroxyprogesterone acetate in humans has been conducted. Medroxyprogesterone acetate is rapidly absorbed from the gastrointestinal tract, and maximum medroxyprogesterone acetate concentrations are obtained between 2 to 4 hours after oral administration.

Effect of Food: Administration of medroxyprogesterone acetate with food increases the bioavailability of medroxyprogesterone acetate. A 10-mg dose of medroxyprogesterone acetate, taken immediately before or after a meal, increased medroxyprogesterone acetate Cmax (50 to 70%) and AUC (18 to 33%). The half-life of medroxyprogesterone acetate was not changed with food.

Distribution: Medroxyprogesterone acetate is approximately 90% protein bound, primarily to albumin; no medroxyprogesterone acetate binding occurs with sex-hormone binding globulin. The unbound medroxyprogesterone acetate modulates pharmacologic responses.

Metabolism: Following oral dosing, medroxyprogesterone acetate is extensively metabolized in the liver via ring A and/or side-chain hydroxylation, with subsequent conjugation and elimination in the urine. At least 16 medroxyprogesterone acetate metabolites have been identified.

Excretion: Most medroxyprogesterone acetate metabolites are excreted in the urine as glucuronide conjugates with only minor amounts excreted as sulfates. Mean percent dose excreted in the 24-hour urine of patients with fatty liver as intact medroxyprogesterone acetate after a 10-mg or 100-mg dose was 7.3% and 6.4%, respectively.

Special Populations

Renal Insufficiency: The pharmacokinetics of medroxyprogesterone acetate in patients with varying degrees of renal insufficiency have not been investigated. The renal clearance of medroxyprogesterone acetate is negligible and a decrease in total body clearance is not expected in patients with renal insufficiency.

Hepatic Insufficiency: Medroxyprogesterone acetate is almost exclusively eliminated via hepatic metabolism. In 14 patients with advanced liver disease, medroxyprogesterone acetate disposition was significantly altered (reduced elimination). As such, medroxyprogesterone acetate is contraindicated in patients with severe hepatic disease (see CONTRAINDICATIONS). However, for patients with mild-moderate degree of hepatic impairment, a lower dose of medroxyprogesterone acetate or a less frequent administration should be considered.

Drug -Drug Interactions

No formal pharmacokinetic drug-drug interaction studies have been conducted with medroxyprogesterone acetate. However, published literature indicates that coadministration of conjugated estrogens with medroxyprogesterone acetate does not affect the pharmacokinetic profile of medroxyprogesterone acetate; similarly, medroxyprogesterone acetate does not affect the pharmacokinetic profile of the conjugated or unconjugated estrogens. Literature data also indicate that concomitant administration with aminoglutethimide would significantly reduce serum concentrations of medroxyprogesterone acetate, likely by increasing the clearance of the drug.

CLINICAL STUDIES

The use of unopposed estrogen therapy has been associated with an increased risk of endometrial hyperplasia, a possible precursor of endometrial carcinoma.1 The incidence of estrogen-associated endometrial hyperplasia and endometrial cancer was assessed in two large, long-term, randomized clinical trials. The histological results of the clinical studies indicate that the addition of medroxyprogesterone acetate to an estrogen replacement regimen for 12 to 14 days per cycle reduces the incidence of endometrial hyperplasia in women with intact uteri. The addition of a progestin to 0.625 mg conjugated estrogen has not been shown to interfere with the efficacy of 0.625 mg conjugated estrogen for its approved indications.1-3

A 3-year, double-blind, placebo-controlled study was conducted in which nonhysterectomized, postmenopausal women between the ages of 45 and 64 years were randomized to receive placebo, conjugated estrogen only, or conjugated estrogen plus cyclic medroxyprogesterone acetate. The treatment group receiving 10 mg medroxyprogesterone acetate plus 0.625 mg conjugated estrogens showed a significantly lower rate of hyperplasia in comparison to the group given 0.625 mg conjugated estrogens only. The 3-year histological results are summarized in Table 2.

Table 2. Number (%) of Endometrial Biopsy Changes Since Baseline After 3 Years of Treatment *
Histological ResultsPlacebo
(n=119)
CEE
(n=119)
MPA + CEE
(n=118)
*
Includes most extreme abnormal result
CEE = conjugated equine estrogens 0.625 mg/day
MPA = medroxyprogesterone acetate

Normal/No hyperplasia (%)

116 (97)

45 (38)

112 (95)

Simple (cystic) hyperplasia (%)

1 (1)

33 (28)

4 (3)

Complex (adenomatous) hyperplasia (%)

1 (1)

27 (22)

2 (2)

Atypia (%)

0

14 (12)

0

Adenocarcinoma (%)

1 (1)

0

0

In a second study, postmenopausal women between the ages of 45 and 65 years were enrolled in a 1-year, double-blind study. All patients received conjugated estrogen 0.625 mg every day of a 28-day cycle, and were randomized to receive cyclic medroxyprogesterone acetate 5 mg, cyclic medroxyprogesterone acetate 10 mg, or conjugated estrogen only. The treatment groups receiving medroxyprogesterone acetate 5 or 10 mg plus conjugated estrogens showed a significantly lower rate of hyperplasia in comparison to the group given conjugated estrogens only. The incidence of endometrial hyperplasia is shown in Table 3.

Table 3. Number (%) of Women with Endometrial Hyperplasia at 1 Year
CEE *MPA + CEE *
(n=283)MPA 5 mg
(n=277)
MPA 10 mg
(n=272)
*
CEE = conjugated equine estrogen 0.625 mg every day of a 28-day cycle.
Cyclic medroxyprogesterone acetate on days 15 to 28

Cystic hyperplasia (%)

55 (19)

3 (1)

0

Adenomatous hyperplasia without atypia

2 (1)

0

0

INDICATIONS AND USAGE

Medroxyprogesterone acetate tablets are indicated for secondary amenorrhea and for abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology, such as fibroids or uterine cancer. Medroxyprogesterone acetate tablets are also indicated to reduce the incidence of endometrial hyperplasia in nonhysterectomized postmenopausal women receiving 0.625 mg conjugated estrogen.

CONTRAINDICATIONS

1. Thrombophlebitis, thromboembolic disorders, cerebral apoplexy or patients with a past history of these conditions.

2. Liver dysfunction or disease.

3. Known or suspected malignancy of breast or genital organs.

4. Undiagnosed vaginal bleeding.

5. Missed abortion.

6. As a diagnostic test for pregnancy.

7. Known sensitivity to medroxyprogesterone acetate tablets.

8. Known or suspected pregnancy.

WARNINGS

1. The physician should be alert to the earliest manifestations of thrombotic disorders (thrombophlebitis, cerebrovascular disorders, pulmonary embolism, and retinal thrombosis). Should any of these occur or be suspected, the drug should be discontinued immediately.

2. Beagle dogs treated with medroxyprogesterone acetate developed mammary nodules some of which were malignant. Although nodules occasionally appeared in control animals, they were intermittent in nature, whereas the nodules in the drug-treated animals were larger, more numerous, persistent, and there were some breast malignancies with metastases. Their significance with respect to humans has not been established.

3. Discontinue medication pending examination if there is sudden partial or complete loss of vision, or if there is a sudden onset of proptosis, diplopia or migraine. If examination reveals papilledema or retinal vascular lesions, medication should be withdrawn.

4. Detectable amounts of progestin have been identified in the milk of mothers receiving the drug. The effect of this on the nursing infant has not been determined.

5. Usage in pregnancy is contraindicated.

6. Retrospective studies of morbidity and mortality in Great Britain and studies of morbidity in the United States have shown a statistically significant association between thrombophlebitis, pulmonary embolism, and cerebral thrombosis and embolism and the use of oral contraceptives.4-7 The estimate of the relative risk of thromboembolism in the study by Vessey and Doll6 was about sevenfold, while Sartwell and associates7 in the United States found a relative risk of 4.4, meaning that the users are several times as likely to undergo thromboembolic disease without evident cause as nonusers. The American study also indicated that the risk did not persist after discontinuation of administration, and that it was not enhanced by long continued administration. The American study was not designed to evaluate a difference between products.

PRECAUTIONS

General

1. The pretreatment physical examination should include special reference to breast and pelvic organs, as well as Papanicolaou smear.

2. Because progestogens may cause some degree of fluid retention, conditions which might be influenced by this factor, such as epilepsy, migraine, asthma, cardiac or renal dysfunction, require careful observation.

3. In cases of breakthrough bleeding, as in all cases of irregular bleeding per vaginum, nonfunctional causes should be borne in mind. In cases of undiagnosed vaginal bleeding, adequate diagnostic measures are indicated.

4. Patients who have a history of psychic depression should be carefully observed and the drug discontinued if the depression recurs to a serious degree.

5. Any possible influence of prolonged progestin therapy on pituitary, ovarian, adrenal, hepatic or uterine functions awaits further study.

6. Diabetic patients should be carefully observed while receiving progestin therapy.

7. The age of the patient constitutes no absolute limiting factor although treatment with progestins may mask the onset of the climacteric.

8. The pathologist should be advised of progestin therapy when relevant specimens are submitted.

9. Because of the occasional occurrence of thrombotic disorders, (thrombophlebitis, pulmonary embolism, retinal thrombosis, and cerebrovascular disorders) in patients taking estrogen-progestin combinations and since the mechanism is obscure, the physician should be alert to the earliest manifestation of these disorders.

Carcinogenesis, Mutagenesis, Impairment of Fertility

Long-term intramuscular administration of medroxyprogesterone acetate has been shown to produce mammary tumors in beagle dogs. There was no evidence of a carcinogenic effect associated with the oral administration of medroxyprogesterone acetate tablets to rats and mice. Medroxyprogesterone acetate was not mutagenic in a battery of in vitro or in vivo genetic toxicity assays.

Medroxyprogesterone acetate at high doses is an antifertility drug and high doses would be expected to impair fertility until the cessation of treatment.

Information for the Patient

See Patient Information at the end of insert.

Pregnancy

Pregnancy Category X–Medroxyprogesterone acetate tablets are contraindicated during pregnancy. Several reports suggest an association between intrauterine exposure to progestational drugs in the first trimester of pregnancy and genital abnormalities in male and female fetuses. The risk of hypospadias in male fetuses may be doubled with exposure to these drugs. Some progestational drugs induce mild virilization of the external genitalia of female fetuses.

Nursing Mothers

The administration of any drug to nursing mothers should be done only when clearly necessary since many drugs are excreted in human milk. Detectable amounts of progestin have been identified in the milk of nursing mothers receiving progestins. The effect of this on the nursing infant has not been determined.

Pediatric Use

The safety and effectiveness of medroxyprogesterone acetate tablets in pediatric patients has not been established.

ADVERSE REACTIONS

Breast– Breast tenderness or galactorrhea has been reported.

Skin– Sensitivity reactions consisting of urticaria, pruritus, edema and generalized rash have occurred. Acne, alopecia and hirsutism have been reported.

Thromboembolic Phenomena– Thromboembolic phenomena including thrombophlebitis and pulmonary embolism have been reported.

Other– The following adverse reactions have been observed in women taking progestins, including medroxyprogesterone acetate tablets:

breakthrough bleeding cholestatic jaundice

spotting anaphylactoid

change in menstrual flow reactions and anaphylaxis

amenorrhea rash (allergic) with

edema and without pruritus

change in weight mental depression

(increase or decrease) pyrexia

changes in cervical insomnia

erosion and cervical nausea

secretions somnolence

Although available evidence is suggestive of an association, such a relationship has been neither confirmed nor refuted for the following serious adverse reactions:

neuro-ocular lesions, eg, retinal thrombosis and optic neuritis.

The following adverse reactions have been observed in patients receiving estrogen-progestin combination drugs:

rise in blood pressure in fatigue

susceptible individuals backache

premenstrual-like syndrome hirsutism

changes in libido loss of scalp hair

changes in appetite erythema multiforme

cystitis-like syndrome erythema nodosum

headache hemorrhagic eruption

nervousness itching

dizziness

Laboratory Tests– The following laboratory results may be altered

by the use of estrogen-progestin combination drugs:

Increased sulfobromophthalein retention and other hepatic function tests.

Coagulation tests: increase in prothrombin factors VII, VIII, IX and X.

Metyrapone test.

Pregnanediol determination.

Thyroid function: increase in PBI, and butanol extractable protein bound iodine and decrease in T3 uptake values.

DOSAGE AND ADMINISTRATION

Secondary Amenorrhea– Medroxyprogesterone acetate tablets may be given in dosages of 5 or 10 mg daily for 5 to 10 days. A dose for inducing an optimum secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen is 10 mg of medroxyprogesterone acetate daily for 10 days. In cases of secondary amenorrhea, therapy may be started at any time. Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing medroxyprogesterone acetate tablets therapy.

Abnormal Uterine Bleeding Due to Hormonal Imbalance in theAbsence of Organic Pathology– Beginning on the calculated 16th or 21st day of the menstrual cycle, 5 or 10 mg of medroxyprogesterone acetate may be given daily for 5 to 10 days. To produce an optimum secretory transformation of an endometrium that has been adequately primed with either endogenous or exogenous estrogen, 10 mg of medroxyprogesterone acetate daily for 10 days beginning on the 16th day of the cycle is suggested. Progestin withdrawal bleeding usually occurs within three to seven days after discontinuing therapy with medroxyprogesterone acetate tablets. Patients with a past history of recurrent episodes of abnormal uterine bleeding may benefit from planned menstrual cycling with medroxyprogesterone acetate tablets.

Reduction of endometrial hyperplasia in post-menopausal women receiving 0.625 mg conjugated estrogens– Medroxyprogesterone acetate tablets may be given in dosages of 5 or 10 mg daily for 12 to 14 consecutive days per month, either beginning on the 1st day of the cycle or the 16th day of the cycle.

HOW SUPPLIED

Medroxyprogesterone acetate tablets are available:

Medroxyprogesterone acetate 10 mg tablets are available from Cardinal Health in unit dose packages of 100 tablets.

10 mg, unit dose package of 100 tablets, NDC 55154-0533-4

Overbagged with 10 tablets per bag, NDC 55154-0533-0

Store at controlled room temperature 20° to 25°C (68° to 77°F)

[see USP].

REFERENCES

1. Writing Group for the PEPI Trial: Effects of hormone replacement therapy on endometrial histology in postmenopausal women. JAMA 275:370-375, 1996.

2. Woodruff JD, Pickar JH: Incidence of endometrial hyperplasia in postmenopausal women taking conjugated estrogens (Premarin) with medroxyprogesterone acetate or conjugated estrogens alone (The Menopause Study Group). Am J Obstet Gynecol 170:1213-1223, 1994.

3. Speroff L, Rowan J, Symons J, et al: The comparative effect on bone density, endometrium, and lipids of continuous hormones as replacement therapy (CHART Study) JAMA 276:1397-1403, 1996.

4. Royal College of General Practitioners: Oral contraception and thromboembolic disease. J Coll Gen Pract 13:267-279, 1967.

5. Inman WHW, Vessey MP: Investigation of deaths from pulmonary, coronary, and cerebral thrombosis and embolism in women of child-bearing age. Br Med J 2:193-199, 1968.

6. Vessey MP, Doll R: Investigation of relation between use of oral contraceptives and thromboembolic disease. A further report. Br Med J 2:651-657, 1969.

7. Sartwell PE, Masi AT, Arthes FG, et al: Thromboembolism and oral contraceptives: An epidemiological case-control study. Am J. Epidemiol 90:365-380. 1969.

The text of the patient insert for progesterone and progesterone-like

drugs is set forth below.

PATIENT INFORMATION

Medroxyprogesterone acetate tablets contain medroxyprogesterone acetate, a progesterone. The information below is that which the U.S. Food and Drug Administration requires be provided for all patients taking progesterones. The information below relates only to the risk to the unborn child associated with use of progesterone during pregnancy. For further information on the use, side effects and other risks associated with this product, ask your doctor.

WARNING FOR WOMEN

Progesterone or progesterone-like drugs have been used to prevent miscarriage in the first few months of pregnancy. No adequate evidence is available to show that they are effective for this purpose. Furthermore, most cases of early miscarriage are due to causes which could not be helped by these drugs.

There is an increased risk of minor birth defects in children whose mothers take this drug during the first 4 months of pregnancy. Several reports suggest an association between mothers who take these drugs in the first trimester of pregnancy and genital abnormalities in male and female babies. The risk to the male baby is the possibility of being born with a condition in which the opening of the penis is on the underside rather than the tip of the penis (hypospadias). Hypospadias occurs in about 5 to 8 per 1,000 male births and is about doubled with exposure to these drugs. There is not enough information to quantify the risk to exposed female fetuses, but enlargement of the clitoris and fusion of the labia may occur, although rarely.

Therefore, since drugs of this type may induce mild masculinization of the external genitalia of the female fetus, as well as hypospadias in the male fetus, it is wise to avoid using the drug during the first trimester of pregnancy.

These drugs have been used as a test for pregnancy but such use is no longer considered safe because of possible damage to a developing baby. Also, more rapid methods for testing for pregnancy are now available.

If you take medroxyprogesterone acetate tablets and later find you were pregnant when you took them, be sure to discuss this with your doctor as soon as possible.

Rx only

Distributed by:

Greenstone Ltd.

Peapack, NJ 07977

Revised March 2004 820 107 000

Repackaged By:

Cardinal Health

Zanesville OH 43701

IU39993800607

Patient labeling for:

Medroxyprogesterone Acetate Tablets, USP

Medroxyprogesterone acetate tablets contain

medroxyprogesterone acetate, a progesterone.

The information below is that which

the U.S. Food and Drug Administration

requires be provided for all patients taking

progesterones. The information below

relates only to the risk to the unborn child

associated with use of progesterone during

pregnancy. For further information on the

use, side effects and other risks associated

with this product, ask your doctor.

WARNING FOR WOMEN

Progesterone or progesterone-like drugs

have been used to prevent miscarriage in the

first few months of pregnancy. No adequate

evidence is available to show that they are

effective for this purpose. Furthermore, most

cases of early miscarriage are due to causes

which could not be helped by these drugs.

There is an increased risk of minor birth

defects in children whose mothers take this

drug during the first 4 months of pregnancy.

Several reports suggest an association

between mothers who take these drugs in

the first trimester of pregnancy and genital

abnormalities in male and female babies.

The risk to the male baby is the possibility of

being born with a condition in which the

opening of the penis is on the underside

rather than the tip of the penis (hypospadias).

Hypospadias occurs in about 5 to 8

per 1,000 male births and is about doubled

with exposure to these drugs. There is not

enough information to quantify the risk to

exposed female fetuses, but enlargement of

the clitoris and fusion of the labia may

occur, although rarely.

Therefore, since drugs of this type may

induce mild masculinization of the external

genitalia of the female fetus, as well as

hypospadias in the male fetus, it is wise to

avoid using the drug during the first

trimester of pregnancy.

These drugs have been used as a test for

pregnancy but such use is no longer considered

safe because of possible damage to a

developing baby. Also, more rapid methods

for testing for pregnancy are now available.

If you take medroxyprogesterone acetate

tablets and later find you were pregnant

when you took them, be sure to discuss this

with your doctor as soon as possible.

Distributed by: Greenstone Ltd.

Peapack, NJ 07977 P06176

Revised July 2004 820 097 000

IU3999380A0807

PRINCIPAL DISPLAY PANEL - Carton

Medroxyprogesterone Acetate Tablets, USP

10 mg

100 Tablets

Medroxyprogesterone Acetate Carton

PRINCIPAL DISPLAY PANEL - Pouch

Medroxyprogesterone Acetate Tablet, USP

10 mg

Medroxyprogesterone Acetate Pouch

Principal Display Panel - Bag

Medroxyprogesterone Acetate Tablets, USP

10 mg

10 Tablets

Bag Label
MEDROXYPROGESTERONE ACETATE 
medroxyprogesterone acetate tablet
Product Information
Product TypeHUMAN PRESCRIPTION DRUGItem Code (Source)NDC:55154-0533(NDC:59762-3742)
Route of AdministrationORAL
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
medroxyprogesterone acetate (UNII: C2QI4IOI2G) (medroxyprogesterone - UNII:HSU1C9YRES) medroxyprogesterone acetate10 mg
Inactive Ingredients
Ingredient NameStrength
calcium stearate (UNII: 776XM7047L)  
starch, corn (UNII: O8232NY3SJ)  
LACTOSE, UNSPECIFIED FORM (UNII: J2B2A4N98G)  
mineral oil (UNII: T5L8T28FGP)  
sorbic acid (UNII: X045WJ989B)  
sucrose (UNII: C151H8M554)  
talc (UNII: 7SEV7J4R1U)  
Product Characteristics
ColorWHITE (WHITE) Score2 pieces
ShapeROUND (ROUND) Size7mm
FlavorImprint Code G3742
Contains    
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:55154-0533-4100 in 1 CARTON06/03/195901/31/2014
1NDC:55154-0533-61 in 1 POUCH; Type 0: Not a Combination Product
2NDC:55154-0533-010 in 1 BAG06/03/195907/31/2014
21 in 1 POUCH; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
NDA authorized genericNDA01183906/03/195907/31/2014
Labeler - Cardinal Health (188557102)
Establishment
NameAddressID/FEIBusiness Operations
Cardinal Health188557102REPACK(55154-0533)

Revised: 10/2017
 
Cardinal Health