REFRESH OPTIVE ADVANCED- carboxymethylcellulose sodium, glycerin, polysorbate 80 solution/ drops 
Allergan, Inc.

----------

Refresh Optive ADVANCED

Refresh Optive ADVANCED (Preservative-free) 

Drug Facts

Active ingredients

Carboxymethylcellulose sodium 0.5%

Glycerin 1%

Polysorbate 80 0.5%

Purpose

Eye lubricant

Eye lubricant

Eye lubricant

Uses

Warnings

Stop use and ask a doctor if

you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions

To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

Other information

Inactive ingredients

Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide (to adjust pH).

Questions or comments?

1.800.678.1605

refreshbrand.com

v1.0DFL4491

PRINCIPAL DISPLAY PANEL

NDC 0023-4491-30

Single-Use Containers
Preservative-free

Refresh
Optive®
ADVANCED
Lubricant Eye Drops

TRIPLE-ACTION RELIEF
Lubricates, Hydrates & Protects
Great for Sensitive Eyes

30 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

NDC 0023-4491-30
Single-Use Containers
Preservative-free
Refresh
Optive®
ADVANCED
Lubricant Eye Drops
TRIPLE-ACTION RELIEF
Lubricates, Hydrates & Protects
Great for Sensitive Eyes
30 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

     

REFRESH OPTIVE ADVANCED 
carboxymethylcellulose sodium, glycerin, polysorbate 80 solution/ drops
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:0023-4491
Route of AdministrationOPHTHALMIC
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
carboxymethylcellulose sodium (UNII: K679OBS311) (carboxymethylcellulose - UNII:05JZI7B19X) carboxymethylcellulose sodium5 mg  in 1 mL
glycerin (UNII: PDC6A3C0OX) (glycerin - UNII:PDC6A3C0OX) glycerin10 mg  in 1 mL
polysorbate 80 (UNII: 6OZP39ZG8H) (polysorbate 80 - UNII:6OZP39ZG8H) polysorbate 805 mg  in 1 mL
Inactive Ingredients
Ingredient NameStrength
boric acid (UNII: R57ZHV85D4)  
CARBOMER COPOLYMER TYPE A (ALLYL PENTAERYTHRITOL CROSSLINKED) (UNII: 71DD5V995L)  
castor oil (UNII: D5340Y2I9G)  
erythritol (UNII: RA96B954X6)  
levocarnitine (UNII: 0G389FZZ9M)  
water (UNII: 059QF0KO0R)  
sodium hydroxide (UNII: 55X04QC32I)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:0023-4491-055 in 1 CARTON01/15/2013
10.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
2NDC:0023-4491-3030 in 1 CARTON01/15/2013
20.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC Monograph DrugM01801/15/2013
Labeler - Allergan, Inc. (144796497)

Revised: 9/2022
Document Id: 0f33d84a-ad59-479a-877c-a02cf4dd8518
Set id: ebd0839e-2e1d-4e0e-986c-19f1f5c76358
Version: 10
Effective Time: 20220915
 
Allergan, Inc.