REFRESH OPTIVE ADVANCED- carboxymethylcellulose sodium, glycerin, polysorbate 80 solution/ drops 
Allergan, Inc.

Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

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Refresh Optive ADVANCED unit dose

Drug Facts

Active ingredients

Carboxymethylcellulose sodium 0.5%

Glycerin 1%

Polysorbate 80 0.5%

Purpose

Eye lubricant

Eye lubricant

Eye lubricant

Uses

Warnings

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions

To open, TWIST AND PULL TAB TO REMOVE. Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

Other information

Inactive ingredients

Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; purified water; and sodium hydroxide.

Questions or comments?

Telephone1.800.678.1605

refreshbrand.com

PDP

Preservative-free NDC 0023-4491-30
REFRESH AMERICA
SENDING EYE DROPS TO OUR FIRST RESPONDERS

Refresh
Optive
®
ADVANCED
Lubricant Eye Drops

TRIPLE-ACTION RELIEF

Clinically proven to lubricate, hydrate,
and protect natural tears from evaporating

30 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

Carton
REFRESH OPTIVE ADVANCED 
carboxymethylcellulose sodium, glycerin, polysorbate 80 solution/ drops
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:0023-4491
Route of AdministrationOPHTHALMIC
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
carboxymethylcellulose sodium (UNII: K679OBS311) (carboxymethylcellulose - UNII:05JZI7B19X) carboxymethylcellulose sodium5 mg  in 1 mL
glycerin (UNII: PDC6A3C0OX) (glycerin - UNII:PDC6A3C0OX) glycerin10 mg  in 1 mL
polysorbate 80 (UNII: 6OZP39ZG8H) (polysorbate 80 - UNII:6OZP39ZG8H) polysorbate 805 mg  in 1 mL
Inactive Ingredients
Ingredient NameStrength
boric acid (UNII: R57ZHV85D4)  
carbomer copolymer type A (UNII: 71DD5V995L)  
castor oil (UNII: D5340Y2I9G)  
erythritol (UNII: RA96B954X6)  
levocarnitine (UNII: 0G389FZZ9M)  
water (UNII: 059QF0KO0R)  
sodium hydroxide (UNII: 55X04QC32I)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:0023-4491-055 in 1 CARTON01/15/2013
10.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
2NDC:0023-4491-3030 in 1 CARTON01/15/2013
20.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC MONOGRAPH FINALpart34901/15/2013
Labeler - Allergan, Inc. (144796497)

Revised: 10/2016
Document Id: d106254c-c4a3-47f4-b7ec-f1fd6046fd62
Set id: ebd0839e-2e1d-4e0e-986c-19f1f5c76358
Version: 6
Effective Time: 20161015
 
Allergan, Inc.