REFRESH NATURE CREAM- citric acid, glycerin cream 
GP International Corp.

Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

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82790

purpose

Acne Control

Use

​Daily Moisturizing and skin repairing

Warnings

Do not use on cuts, or if you have extremely sensitive skin

Do not mix the product with other AHA, BHA, Steroids related Products

which can cause irritation characterized by redness,

itching, and burning

Warnings

When using this product do not use in or near the eyes.

Warnings

Stop use if irritation become severe and ask a doctor

Warnings

For external use only avoid contact with the eyes,lips and mouth

Warnings

Keep out of reach of children If swallowed, please get medical help

Directions

Directions Cleanse the skin thoroughly before applying

the product * Apply gently a thin layer on the desired area 2 to 3 times daily

active ingredient

Glycerin 5.0 % Skin Protection

Xanthium Strumarium Fruit Extract 0.17% Antioxidant

Cnidium Monnieri Fruit Extract 0.17% Anti Flammatory

Angelica Acutiloba Root Extract 0.17% Skin lightening

Citric Acid 0.01% Exfoliating

Malic Acid 0.003% Exfoliating

Inactive Ingredients

Water, Butylene Glycol Hydrogenated Polydecene, Beeswax, Cetearyl Olivate, Methylpropanediol, Pentaerythrityl Tetraethylhexanoate, Ethylhexyl Palmitate, Cetyl Ethylhexanoate, Sorbitan Olivate, Stearic Acid, Rhus Semialata Gall Extract, Hexanediol, Hydrolyzed Collagen, Cetearyl Alcohol , Dimethicone, Sodium Acrylate, Sodium Acryloyldimethyl, Taurate, Copolymer,Palmitic Acid, Propanediol, Isohexadecane, Hydroxyacetophenone, Carbomer, Arginine, Limonia Acidissima Extract,Centella Asiatica Extract, Chlorphenesin, Ethylhexylglycerin, Polysorbate 80, Xanthan Gum,Fragrance,Benzyl Salicylate,Coumarin, Butylphenyl Methylpropional, Limonene, Linalool, Disodium EDTA,Sodium Lactate,Arachidic Acid,Citric Acid,Sodium PCA,Myristic Acid,Lactic Acid,Pyruvic Acid,Tartaric Acid,Alcohol,Polysorbate 20, Madecassoside

Daily Hydrating Cream for Acne Control

Daily Hydrating Cream for Acne Control

1

REFRESH NATURE CREAM 
citric acid, glycerin cream
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:82790-301
Route of AdministrationTOPICAL
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
XANTHIUM STRUMARIUM FRUIT (UNII: TN770YC17C) (XANTHIUM STRUMARIUM FRUIT - UNII:TN770YC17C) XANTHIUM STRUMARIUM FRUIT0.17 g  in 100 g
CNIDIUM MONNIERI FRUIT (UNII: V1IA3S3CUS) (CNIDIUM MONNIERI FRUIT - UNII:V1IA3S3CUS) CNIDIUM MONNIERI FRUIT0.17 g  in 100 g
MALIC ACID (UNII: 817L1N4CKP) (MALIC ACID - UNII:817L1N4CKP) MALIC ACID0.003 g  in 100 g
GLYCERIN (UNII: PDC6A3C0OX) (GLYCERIN - UNII:PDC6A3C0OX) GLYCERIN5 g  in 100 g
ANGELICA ACUTILOBA ROOT (UNII: 3W51R3EK30) (ANGELICA ACUTILOBA ROOT - UNII:3W51R3EK30) ANGELICA ACUTILOBA ROOT0.17 g  in 100 g
LIMONIA ACIDISSIMA WHOLE (UNII: MU5C4X2819) (LIMONIA ACIDISSIMA WHOLE - UNII:MU5C4X2819) LIMONIA ACIDISSIMA WHOLE0.17 g  in 100 g
CITRIC ACID MONOHYDRATE (UNII: 2968PHW8QP) (ANHYDROUS CITRIC ACID - UNII:XF417D3PSL) ANHYDROUS CITRIC ACID0.01 g  in 100 g
Inactive Ingredients
Ingredient NameStrength
STEARIC ACID (UNII: 4ELV7Z65AP)  
SODIUM ACRYLOYLDIMETHYLTAURATE (UNII: 2T9Q6EKI0G)  
TAURINE (UNII: 1EQV5MLY3D)  
GLATIRAMER ACETATE (UNII: 5M691HL4BO)  
POLYSORBATE 20 (UNII: 7T1F30V5YH)  
MADECASSOSIDE (UNII: CQ2F5O6YIY)  
MARINE COLLAGEN, SOLUBLE (UNII: 8JC99XGU4W)  
SODIUM ACRYLATE (UNII: 7C98FKB43H)  
BUTYLENE GLYCOL (UNII: 3XUS85K0RA)  
HYDROGENATED POLYDECENE TYPE I (UNII: U333RI6EB7)  
LACTIC ACID (UNII: 33X04XA5AT)  
ISOHEXADECANE (UNII: 918X1OUF1E)  
HYDROXYACETOPHENONE (UNII: G1L3HT4CMH)  
ARACHIDIC ACID (UNII: PQB8MJD4RB)  
SODIUM PYRROLIDONE CARBOXYLATE (UNII: 469OTG57A2)  
MYRISTIC ACID (UNII: 0I3V7S25AW)  
PALMITIC ACID (UNII: 2V16EO95H1)  
YELLOW WAX (UNII: 2ZA36H0S2V)  
CETEARYL OLIVATE (UNII: 58B69Q84JO)  
METHYLPROPANEDIOL (UNII: N8F53B3R4R)  
PENTAERYTHRITYL TETRAETHYLHEXANOATE (UNII: XJ7052W897)  
CARBOMER HOMOPOLYMER, UNSPECIFIED TYPE (UNII: 0A5MM307FC)  
XANTHAN GUM (UNII: TTV12P4NEE)  
BUTYLPHENYL METHYLPROPIONAL (UNII: T7540GJV69)  
RHUS CHINENSIS GALL (UNII: 4W3Y2V7J3R)  
CETOSTEARYL ALCOHOL (UNII: 2DMT128M1S)  
ETHYLHEXYLGLYCERIN (UNII: 147D247K3P)  
BENZYL SALICYLATE (UNII: WAO5MNK9TU)  
COUMARIN (UNII: A4VZ22K1WT)  
LIMONENE, (+/-)- (UNII: 9MC3I34447)  
PROPANEDIOL (UNII: 5965N8W85T)  
ARGININE (UNII: 94ZLA3W45F)  
CENTELLA ASIATICA TRITERPENOIDS (UNII: 4YS74Q4G4J)  
POLYSORBATE 80 (UNII: 6OZP39ZG8H)  
LINALOOL, (+/-)- (UNII: D81QY6I88E)  
SORBITAN OLIVATE (UNII: MDL271E3GR)  
HEXANEDIOL (UNII: ZIA319275I)  
DIMETHICONE (UNII: 92RU3N3Y1O)  
WATER (UNII: 059QF0KO0R)  
ETHYLHEXYL PALMITATE (UNII: 2865993309)  
CETYL ETHYLHEXANOATE (UNII: 134647WMX4)  
FRAGRANCE LEMON ORC2001060 (UNII: K1725A7G95)  
CHLORPHENESIN (UNII: I670DAL4SZ)  
EDETATE DISODIUM ANHYDROUS (UNII: 8NLQ36F6MM)  
SODIUM LACTATE (UNII: TU7HW0W0QT)  
PYRUVIC ACID (UNII: 8558G7RUTR)  
TARTARIC ACID (UNII: W4888I119H)  
ALCOHOL (UNII: 3K9958V90M)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:82790-301-01110 g in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product06/22/2022
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC monograph not finalpart33406/22/2022
Labeler - GP International Corp. (695896955)
Registrant - GP International Corp. (695896955)
Establishment
NameAddressID/FEIBusiness Operations
GP International Corp.695896955manufacture(82790-301)

Revised: 6/2022
Document Id: e203bdca-15d3-e8d7-e053-2995a90a0e7b
Set id: e203bdca-15d2-e8d7-e053-2995a90a0e7b
Version: 1
Effective Time: 20220622
 
GP International Corp.