DESCRIPTION
CHORULON® is a freeze-dried preparation of chorionic gonadotropin (human Chorionic Gonadotropin or hCG) for intramuscular administration after reconstitution. When reconstituted with the accompanying sterile diluent, each 10 mL vial contains 10,000 I.U. chorionic gonadotropin (equivalent to 10,000 USP Units chorionic gonadotropin) and 10 mg mannitol, with mono- and disodium phosphate to adjust the pH of the solution.
ACTION
Chorionic gonadotropin has luteinizing hormone-like activity with little or no follicle stimulating or estrogenic activity.
INDICATIONS
DOSAGE AND ADMINISTRATION
To reconstitute, transfer the contents of one vial of sterile diluent into one vial of freeze-dried powder. The resulting 10 mL of CHORULON® contains 10,000 I.U. chorionic gonadotropin.
COWS: The contents of one vial (10 mL) of reconstituted CHORULON® should be administered as a single deep intramuscular injection. Dosage may be repeated in 14 days if the animal's behavior or rectal examination of the ovaries indicates the necessity for retreatment.
FINFISH: CHORULON® should be administered via intramuscular injection just ventral to the dorsal fin for one (1) to three (3) injections. Any single injection should be administered, depending on the fish species, at a dose of 50 to 510 I.U./lb body weight (bw) for males and 67 to 1816 I.U./lb bw for females. Depending on body weight and dose administered, it may be necessary to divide the dose among two or more injection sites to avoid injecting a large volume at a single site.
Summaries of doses tested in representative fish species are contained within the following tables. The dose of CHORULON® to be used in other species of finfish may differ from those species listed in the tables, but should fall within the suggested range of 50 to 510 I.U./lb bw for males and 67 to 1816 I.U./lb bw for females.
| Nomenclature Common Name, Genus & Species, Family | Tested Dose(s) (I.U./lb bw/injection) | Number of Injection | Injections Interval (h) | |
|---|---|---|---|---|
| Males | Females | |||
| Footnotes: 1, nt = not tested | ||||
| yellow perch, Perca flavescens, Percidae | nt1 | 67-300 | 1 | - |
| striped bass, Morone saxitilis, Percichthyidae | 50-500 | 75-252 | 1 | - |
| white bass, Morone chrysops, Percichthyidae | 65-510 | 91-750 | 1 | - |
| razorback sucker, Xyrauchen texanus, Catostomidae | nt | 100 | 3 | 24 |
| walleye, Stizostedion vitreum, Percidae | 75-400 | 145-830 | 1-3 | 72 |
| red snapper, Lutjanus campechanus, Lutjanidae | 250 | 500 | 1 | - |
| sauger, Stizostedion canadense, Percidae | 500 | 500-1000 | 1 | - |
| Chinese catfish, Clarius fuscus, Clariidae | nt | 1816 | 1 | - |
| Nomenclature Common Name, Genus & Species, Family | Tested Dose(s) (I.U./lb bw/injection) | Number of Injection | Injections Interval (h) | |
|---|---|---|---|---|
| Males | Females | |||
| white bass, Morone chrysops, Percichthyidae | 750 | 1500 | 1 | - |
| walleye, Stizostedion vitreum, Percidae | 750 | 1500 | 1 | - |
| grass carp, Ctenopharyngodon idella, Cyprinidae | 2500 | 5000 | 1 | - |
| channel catfish, Ictalurus punctatus, Ictaluridae | 2500 | 5000 | 1 | - |
ADVERSE REACTIONS
Chorionic gonadotropin is a protein. in the unlikely event of an anaphylactic reaction, epinephrine should be administered. the administration of an antihistamine may also be indicated.
RESIDUE WARNINGS
No withdrawal period is required for cows or brood finfish treated according to label directions. the total dose administered (all injections combined) should not exceed 25,000 i.u. (25 mL) per fish in fish intended for human consumption.
STORAGE AND HANDLING PRECAUTIONS
Store at or below room temperature, 77° F (25°C). Keep out of reach of children. once reconstituted, CHORULON® should be used immediately. unused solution should be disposed of properly and not stored for future use.
HOW SUPPLIED
CHORULON® is supplied in cartons containing five vials of freeze-dried powder and five 10 mL vials of sterile diluent. order Code No. CH-475-1.
