LIQUAMYCIN LA-200- oxytetracycline injection, solution
Each mL contains 200 mg of oxytetracycline base as oxytetracycline dihydrate.
For the treatment of disease in beef cattle; dairy cattle; calves, including preruminating (veal) calves; and swine
For animal use only
Read Entire Package Insert Carefully Before Using This Product
Liquamycin LA-200 (oxytetracycline injection) is a sterile, ready-to-use solution for the administration of the broad-spectrum antibiotic oxytetracycline (Terramycin®) by injection.
Liquamycin LA-200 administered to cattle or swine for the treatment of bacterial pneumonia at a dosage of 9 mg of oxytetracycline per lb of body weight has been demonstrated in clinical trials to be as effective as 2 or 3 repeated, daily treatments of Terramycin Injectable at 3–5 mg/lb of body weight.
Liquamycin LA-200 does not require refrigeration; however, it is recommended that it be stored at room temperature, 15°–30°C (59°–86°F). The antibiotic activity of oxytetracycline is not appreciably diminished in the presence of body fluids, serum, or exudates.
When administered to cattle, muscle discoloration may necessitate trimming of the injection site(s) and surrounding tissues during the dressing procedure.
Discontinue treatment at least 28 days prior to slaughter of cattle and swine. Milk taken from animals during treatment and for 96 hours after the last treatment must not be used for food. Rapid intravenous administration may result in animal collapse.
Oxytetracycline should be administered intravenously slowly over a period of at least 5 minutes.
Exceeding the highest recommended dosage level of drug per lb of body weight per day, administering more than the recommended number of treatments, and/or exceeding 10 mL subcutaneously per injection site in adult beef and dairy cattle, and 5 mL intramuscularly per injection site in adult swine, may result in antibiotic residues beyond the withdrawal period.
Consult with your veterinarian prior to administering this product in order to determine the proper treatment required in the event of an adverse reaction. At the first sign of any adverse reaction, discontinue use of the product and seek the advice of your veterinarian. Some of the reactions may be attributed either to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause.
Shortly after injection, treated animals may have transient hemoglobinuria resulting in darkened urine.
As with all antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. A lack of response by the treated animal, or the development of new signs, may suggest that an overgrowth of nonsusceptible organisms has occurred. If any of these conditions occur, consult your veterinarian.
Since bacteriostatic drugs may interfere with the bactericidal action of penicillin, it is advisable to avoid giving Liquamycin LA-200 in conjunction with penicillin.
Reports of adverse reactions associated with oxytetracycline administration include injection site swelling, restlessness, ataxia, trembling, swelling of eyelids, ears, muzzle, anus and vulva (or scrotum and sheath in males), respiratory abnormalities (labored breathing), frothing at the mouth, collapse and possibly death. Some of these reactions may be attributed to anaphylaxis (an allergic reaction) or to cardiovascular collapse of unknown cause.
Store at room temperature 15°– 30°C (59°–86°F).
Protect from freezing. Use within 28 days of first vial puncture.
Stopper may be punctured a maximum of 40 times.
The use of antibiotics in the management of diseases is based on an accurate diagnosis and an adequate course of treatment. When properly used in the treatment of diseases caused by oxytetracycline-susceptible organisms, most animals that have been treated with Liquamycin LA-200 show a noticeable improvement within 24–48 hours. It is recommended that the diagnosis and treatment of animal diseases be carried out by a veterinarian. Since many diseases look alike but require different types of treatment, the use of professional veterinary and laboratory services can reduce treatment time, costs, and needless losses. Good housing, sanitation, and nutrition are important in the maintenance of healthy animals, and are essential in the treatment of diseased animals.
Liquamycin LA-200 is intended for use in the treatment of the following diseases in beef cattle; dairy cattle; calves, including preruminating (veal) calves; and swine when due to oxytetracycline-susceptible organisms:
Liquamycin LA-200 is indicated in the treatment of pneumonia and shipping fever complex associated with Pasteurella spp. and Hemophilus spp.; infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis; foot rot and diphtheria caused by Fusobacterium necrophorum; bacterial enteritis (scours) caused by Escherichia coli; wooden tongue caused by Actinobacillus lignieresii; leptospirosis caused by Leptospira pomona; and wound infections and acute metritis caused by strains of staphylococci and streptococci organisms sensitive to oxytetracycline.
Liquamycin LA-200 is indicated in the treatment of bacterial enteritis (scours, colibacillosis) caused by Escherichia coli; pneumonia caused by Pasteurella multocida; and leptospirosis caused by Leptospira pomona.
In sows, Liquamycin LA-200 is indicated as an aid in the control of infectious enteritis (baby pig scours, colibacillosis) in suckling pigs caused by Escherichia coli.
Liquamycin LA-200 is to be administered by subcutaneous (SC, under the skin) or intravenous injection according to Beef Quality Assurance Guidelines.
A single dosage of 9 mg of Liquamycin LA-200 per lb of body weight administered subcutaneously is recommended in the treatment of the following conditions: 1) bacterial pneumonia caused by Pasteurella spp. (shipping fever) in calves and yearlings, where retreatment is impractical due to husbandry conditions, such as cattle on range, or where their repeated restraint is inadvisable; 2) infectious bovine keratoconjunctivitis (pinkeye) caused by Moraxella bovis.
Liquamycin LA-200 can also be administered by subcutaneous or intravenous injection at a level of 3–5 mg of oxytetracycline per lb of body weight per day. In the treatment of severe foot rot and advanced cases of other indicated diseases, a dosage level of 5 mg/lb of body weight per day is recommended. Treatment should be continued 24–48 hours following remission of disease signs; however, not to exceed a total of 4 consecutive days. Consult your veterinarian if improvement is not noted within 24–48 hours of the beginning of treatment.
A single dosage of 9 mg of Liquamycin LA-200 per lb of body weight administered intramuscularly in the neck region is recommended in the treatment of bacterial pneumonia caused by Pasteurella multocida in swine, where retreatment is impractical due to husbandry conditions or where repeated restraint is inadvisable.
Liquamycin LA-200 can also be administered by intramuscular injection at a level of 3–5 mg of oxytetracycline per lb of body weight per day. Treatment should be continued 24–48 hours following remission of disease signs; however, not to exceed a total of 4 consecutive days. Consult your veterinarian if improvement is not noted within 24–48 hours of the beginning of treatment.
For sows, administer once intramuscularly in the neck region 3 mg of oxytetracycline per lb of body weight approximately 8 hours before farrowing or immediately after completion of farrowing.
For swine weighing 25 lb of body weight and under, Liquamycin LA-200 should be administered undiluted for treatment at 9 mg/lb but should be administered diluted for treatment at 3 or 5 mg/lb.
|9 mg/lb Dosage||3 or 5 mg/lb Dosage|
|Volume of Undiluted Liquamycin LA-200||Volume of Diluted Liquamycin LA-200|
|Body Weight||9 mg/lb||3 mg/lb||Dilution*||5 mg/lb|
|5 lb||0.2 mL||0.6 mL||1:7||1.0 mL|
|10 lb||0.5 mL||0.9 mL||1:5||1.5 mL|
|25 lb||1.1 mL||1.5 mL||1:3||2.5 mL|
Liquamycin LA-200 is intended for use in the treatment of disease due to oxytetracycline-susceptible organisms in beef cattle; dairy cattle; calves, including preruminating (veal) calves; and swine. A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized by boiling in water for 15 minutes). In cold weather, Liquamycin LA-200 should be warmed to room temperature before administration to animals. Before withdrawing the solution from the bottle, disinfect the rubber cap on the bottle with suitable disinfectant, such as 70% alcohol. The injection site should be similarly cleaned with the disinfectant. Needles of 16–18 gauge and 1–1½ inches long are adequate for intramuscular and subcutaneous injections. Needles 2–3 inches are recommended for intravenous use.
Intramuscular injections in swine should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle in the neck region; avoid blood vessels and major nerves. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site. No more than 5 mL should be injected at any one site in adult swine; rotate injection sites for each succeeding treatment.
Subcutaneous injections in beef cattle, dairy cattle, and calves, including preruminating (veal) calves, should be made by directing the needle of suitable gauge and length through the loose folds of the neck skin in front of the shoulder. Care should be taken to ensure that the tip of the needle has penetrated the skin but is not lodged in muscle. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site. The solution should be injected slowly into the area between the skin and muscles. No more than 10 mL should be injected subcutaneously at any one site in adult beef and dairy cattle; rotate injection sites for each succeeding treatment. The volume administered per injection site should be reduced according to age and body size so that 1–2 mL per site is injected in small calves.
Liquamycin LA-200 may be administered intravenously to beef and dairy cattle. As with all highly concentrated materials, Liquamycin LA-200 should be administered slowly by the intravenous route.
|FIGURE I||FIGURE II|
Restricted Drug (California)—Use Only as Directed
Not For Human Use
Approved by FDA under NADA # 113-232
Kalamazoo, MI 49007
Revised: May 2019
oxytetracycline injection, solution
|Labeler - Zoetis Inc. (828851555)|