DESCRIPTION
BIOMOX® (amoxicillin) is a broad-spectrum, semisynthetic antibiotic which provides bactericidal activity against a wide range of common gram-positive and gram-negative pathogens. Amoxicillin chemically is D-(-)α-amino-p-hydroxybenzyl penicillin trihydrate.
Inactive Ingredients
Cherry Flavor, Silicon Dioxide NF, FD&C Red #40, Polyoxyethylene-Polyoxypropylene Glycol, Sodium Benozate, Sodium Citrate, Sodium Saccharin, and Sucrose
ACTION
Amoxicillin has bactericidal activity against susceptible organisms similar to that of ampicillin. It acts by inhibiting the biosynthesis of bacterial
wall mucopeptides. Most strains of the following gram-positive and gramnegative bacteria have demonstrated susceptibility to: amoxicillin, both in vitro and in vivo: nonpenicillinase-producing staphylococci, alpha- and betahemolytic streptococci, Streptococcus faecalis, Escherichia coli and Proteus mirabilis. Amoxicillin does not resist destruction by penicillinase; therefore, it is not effective against penicillinase-producing bacteria, particularly resistant staphylococci. Most strains of Enterobacter and klebsiella and all strains of Pseudomonas are resistant.
Amoxicillin may be given without regard to meals because it is stable in gastric acid. It is rapidly absorbed following oral administration and diffuses readily into most body fluids and tissues. It diffuses poorly into the brain and spinal fluid except when the meninges are inflamed. Most of the amoxicillin is excreted in the urine unchanged.
INDICATIONS
BIOMOX® (amoxicillin) for oral suspension is indicated in the treatment of the following infections in dogs when caused by susceptible strains of organisms:
BACTERIAL DERMATITIS due to Staphylococcus aureus, Streptococcus spp.; Staphylococcus spp.; and E. coli.
SOFT TISSUE INFECTIONS (abscesses, wounds, lacerations) due to Staphylococcus aureus, Streptococcus spp.; E. coli, Proteus mirabilis and
Staphylococcus spp.
As is true with all antibiotic therapy, appropriate in vitro cultures and sensitivities should be conducted prior to treatment.
CONTRAINDICATIONS
Use of amoxicillin is contraindicated in animals with a history of an allergic reaction to penicillin.
ADVERSE REACTIONS
Amoxicillin is a semisynthetic penicillin and, therefore, has the potential for producing allergic reactions. Epinephrine and/or steroids should be administered if an allergic reaction occurs.
PRECAUTIONS
Until adequate reproductive studies are accomplished, Biomox (amoxicillin) for oral suspension should not be used in pregnant or breeding
animals.
DOSAGE AND ADMINISTRATION
The recommended dosage is 5 mg per pound of body weight administered twice daily for 5 to 7 days. Continue for 48 hours after all symptoms have subsided. If no improvment is noted in 5 days, the diagnosis should be reconsidered and therapy changed.
DIRECTIONS FOR MIXING ORAL SUSPENSION
Add sufficient water to the bottle as indicated in the table below and shake vigorously. Each mL of suspension will contain 50 mg of amoxicillin as the trihydrate.
Note: When stored at room temperature or in refrigerator, discard unused portion of reconstituted suspension after 14 days.
SUPPLY
Bimox® (amoxicillin) for oral suspension is supplied in bottles containing 0.75 g of amoxicillin activity in bottles of 15 mL or 1.5 g of amoxicillin
activity in bottles of 30 mL. After reconstitution with the required amount of water, each mL will contain 50 mg of amoxicillin as the trihydrate.
