Active ingredients

Carboxymethylcellulose sodium 0.5%

Glycerin 1%

Polysorbate 80 0.5%

Purpose

Eye lubricant

Uses

For the temporary relief of burning, irritation, and discomfort due to dryness of the eye or exposure to wind or sun.
May be used as a protectant against further irritation.

Warnings

For external use only.
To avoid contamination, do not touch tip of container to any surface. Replace cap after using.
If solution changes color, do not use.

Stop use and ask a doctor if

you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions

Instill 1 or 2 drops in the affected eye(s) as needed.

Other information

Use only if tape seals on top and bottom flaps are intact.
Use before expiration date marked on container.
Discard 90 days after opening.
Store at 59°-77°F (15°-25°C).
RETAIN THIS CARTON FOR FUTURE REFERENCE.

Inactive ingredients

Boric acid; carbomer copolymer type A; castor oil; erythritol; levocarnitine; puriﬁed water; PURITE® (stabilized oxychloro complex); and sodium hydroxide (to adjust pH).

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ADVANCED

Lubricant Eye Drops

TRIPLE-ACTION RELIEF

Clinically proven to lubricate,
hydrate, and protect
natural tears from evaporating

0.33 fl oz (10 mL) Sterile

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Lubricant Eye Drops
TRIPLE-ACTION RELIEF
Clinically proven to lubricate,
hydrate, and protect
natural tears from evaporating
0.33 fl oz (10 mL) Sterile

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NDC 0023-4307-15

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ADVANCED

Lubricant Eye Drops

TRIPLE-ACTION RELIEF

Clinically proven to lubricate,
hydrate, and protect
natural tears from evaporating

0.5 fl oz (15 mL) Sterile

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Optive®
ADVANCED
Lubricant Eye Drops
TRIPLE-ACTION RELIEF
Clinically proven to lubricate,
hydrate, and protect
natural tears from evaporating
0.5 fl oz (15 mL) Sterile

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ADVANCED

Lubricant Eye Drops

TRIPLE-ACTION RELIEF

Clinically proven to lubricate,
hydrate, and protect
natural tears from evaporating

0.068 fl oz (2 mL) Sterile

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NDC 0023-4307-02 - Sample
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Optive®
ADVANCED
Lubricant Eye Drops
TRIPLE-ACTION RELIEF
Clinically proven to lubricate,
hydrate, and protect
natural tears from evaporating
0.068 fl oz (2 mL) Sterile

REFRESH OPTIVE ADVANCED
carboxymethylcellulose sodium, glycerin, and polysorbate 80 solution/ drops

Product Information
Product Type	HUMAN OTC DRUG	Item Code (Source)	NDC:0023-4307
Route of Administration	OPHTHALMIC

Ingredient Name	Basis of Strength	Strength
Active Ingredient/Active Moiety
carboxymethylcellulose sodium (UNII: K679OBS311) (carboxymethylcellulose - UNII:05JZI7B19X)	carboxymethylcellulose sodium	5 mg in 1 mL
glycerin (UNII: PDC6A3C0OX) (glycerin - UNII:PDC6A3C0OX)	glycerin	10 mg in 1 mL
polysorbate 80 (UNII: 6OZP39ZG8H) (polysorbate 80 - UNII:6OZP39ZG8H)	polysorbate 80	5 mg in 1 mL

Ingredient Name	Strength
Inactive Ingredients
boric acid (UNII: R57ZHV85D4)
carbomer copolymer type A (UNII: 71DD5V995L)
castor oil (UNII: D5340Y2I9G)
erythritol (UNII: RA96B954X6)
levocarnitine (UNII: 0G389FZZ9M)
water (UNII: 059QF0KO0R)
sodium chlorite (UNII: G538EBV4VF)
hydrochloric acid (UNII: QTT17582CB)
sodium hydroxide (UNII: 55X04QC32I)

#	Item Code	Package Description	Marketing Start Date
Packaging
1	NDC:0023-4307-03	1 in 1 CARTON	11/30/2011
1		3 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
2	NDC:0023-4307-10	1 in 1 CARTON	11/30/2011
2		10 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
3	NDC:0023-4307-20	2 in 1 CARTON	11/30/2011
3		10 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
4	NDC:0023-4307-02	1 in 1 CARTON	11/30/2011
4		2 mL in 1 BOTTLE; Type 0: Not a Combination Product
5	NDC:0023-4307-15	1 in 1 CARTON	11/30/2011
5		15 mL in 1 BOTTLE; Type 0: Not a Combination Product

Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
Marketing Information
OTC Monograph Drug	M018	11/30/2011

Labeler - Allergan, Inc. (144796497)

Refresh Optive® ADVANCED Drug Facts

Active ingredients

Purpose

Uses

Warnings

Stop use and ask a doctor if

Keep out of reach of children.

Directions

Other information

Inactive ingredients

Questions or comments?

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