REFRESH OPTIVE ADVANCED- carboxymethylcellulose sodium, glycerin, and polysorbate 80 solution/ drops 
Allergan, Inc.

Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

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Refresh Optive ADVANCED

Drug Facts

Active ingredients

Carboxymethylcellulose sodium 0.5%

Glycerin 1%

Polysorbate 80 0.5%

Purpose

Eye lubricant

Eye lubricant

Eye lubricant

Uses

Warnings

Stop use and ask a doctor if you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions

Instill 1 or 2 drops in the affected eye(s) as needed.

Other information

Inactive ingredients

Boric acid; castor oil; erythritol; levocarnitine; carbomer copolymer type A; purified water; and PURITE® (stabilized oxychloro complex). May also contain sodium hydroxide to adjust pH.

Questions or comments?

Telephone1.800.678.1605

refreshbrand.com

© 2017 Allergan. All rights reserved.
All trademarks are the property of their respective owners.
Revised: June 2, 2017

Refresh

Optive®

ADVANCED

Lubricant Eye Drops

TRIPLE-ACTION RELIEF

Clinically proven to lubricate,

hydrate, and protect

natural tears from evaporating

0.33 fl oz (10 mL) Sterile

Principal Display Panel Carton
REFRESH OPTIVE ADVANCED 
carboxymethylcellulose sodium, glycerin, and polysorbate 80 solution/ drops
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:0023-4307
Route of AdministrationOPHTHALMIC
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
carboxymethylcellulose sodium (UNII: K679OBS311) (carboxymethylcellulose - UNII:05JZI7B19X) carboxymethylcellulose sodium5 mg  in 1 mL
glycerin (UNII: PDC6A3C0OX) (glycerin - UNII:PDC6A3C0OX) glycerin10 mg  in 1 mL
polysorbate 80 (UNII: 6OZP39ZG8H) (polysorbate 80 - UNII:6OZP39ZG8H) polysorbate 805 mg  in 1 mL
Inactive Ingredients
Ingredient NameStrength
boric acid (UNII: R57ZHV85D4)  
castor oil (UNII: D5340Y2I9G)  
erythritol (UNII: RA96B954X6)  
levocarnitine (UNII: 0G389FZZ9M)  
carbomer copolymer type A (UNII: 71DD5V995L)  
water (UNII: 059QF0KO0R)  
sodium chlorite (UNII: G538EBV4VF)  
hydrochloric acid (UNII: QTT17582CB)  
sodium hydroxide (UNII: 55X04QC32I)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:0023-4307-031 in 1 CARTON11/30/2011
13 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
2NDC:0023-4307-101 in 1 CARTON11/30/2011
210 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
3NDC:0023-4307-202 in 1 CARTON11/30/2011
310 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC MONOGRAPH FINALpart34911/30/2011
Labeler - Allergan, Inc. (144796497)

Revised: 6/2016
Document Id: fe97c425-121a-4b44-baf7-9e4eb38b3993
Set id: aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0
Version: 11
Effective Time: 20160615
 
Allergan, Inc.