SYSTANE ULTRA PRESERVATIVE FREE- polyethylene glycol 400 and propylene glycol solution/ drops 
Alcon Laboratories, Inc.

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Drug Facts

Active IngredientsPurpose
Polyethylene Glycol 400 0.4%Lubricant
Propylene Glycol 0.3%Lubricant

Uses

Warnings

For external use only

Do not use

When using the product

Stop use and ask a doctor if you experience any of the following:

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions

Other Information

Inactive ingredients

Aminomethylpropanol, boric acid, hydroxypropyl guar, potassium chloride, purified water, sodium chloride, sorbitol. May contain hydrochloric acid and/or sodium hydroxide to adjust pH.

Questions?

In the U.S. call 1-800-757-9195
alcon.medinfo@alcon.com
www.systane.com

Directions for Use:

Use Diagram

PRINCIPAL DISPLAY PANEL

Preservative-Free

Systane®
LUBRICANT EYE DROPS

ULTRA PF
FAST ACTING
DRY EYE RELIEF

Moisture Rich Formula
Instantly Hydrates

Preservative-Free Bottle

DOCTOR RECOMMENDED #1 BRANDS1

Alcon

STERILE
10 mL (0.34 FL OZ)

LOT:                                         EXP.:

SIDE PANEL:

TAMPER EVIDENT:
For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase.  

1Based on a survey of eye care professionals. Data on file.

Alcon Laboratories, Inc.
Fort Worth, TX 76134 USA
Country of Origin United States
U.S. Pat.: www.alconpatents.com

300068254-0824

Actual Size

Carton

TWIN VALUE PACK

Preservative-Free

Systane®
LUBRICANT EYE DROPS

ULTRA PF
FAST ACTING
DRY EYE RELIEF

Moisture Rich Formula
Instantly Hydrates

Preservative-Free Bottles

DOCTOR RECOMMENDED #1 BRANDS1

Alcon

STERILE
Two 10 mL (0.34 FL OZ) Bottles

LOT:                                         EXP.:

SIDE PANEL:

TAMPER EVIDENT:
For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase.  

1Based on a survey of eye care professionals. Data on file.

Preservative-Free
Fast Acting
Relief for
Sensitive Eyes

Alcon Laboratories, Inc.
Fort Worth, TX 76134 USA
Country of Origin USA
U.S. Pat.: www.alconpatents.com

ACTUAL SIZE

300068255-0824

Carton Label

Preservative-Free

Systane
®
LUBRICANT EYE DROPS

ULTRA PF
FAST ACTING

DRY EYE RELIEF

Moisture Rich Formula
Instantly Hydrates

Preservative-Free Bottle

DOCTOR RECOMMENDED #1 BRANDS1

Alcon

STERILE
10 mL (0.34 fl oz)

LOT:                                         EXP.:

SIDE PANEL:

TAMPER EVIDENT:
For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase.

1Based on a survey of eye care professionals. Data on file.

Alcon Laboratories, Inc.
Fort Worth, TX 76134 USA
Country of Origin: Singapore
U.S. Pat.: www.alconpatents.com

300072082-0525 

Actual Size

Carton Label

Systane®
LUBRICANT EYE DROPS

ULTRA PF

FAST ACTING
DRY EYE RELIEF

10 mL (0.34 FL OZ) STERILE   

Only for use in the eye.
Store at room temperature.
Discard 90 days after opening.
TAMPER EVIDENT: For your protection, this bottle has a tamper evident ring around the bottom of the cap. Do not use if this ring is damaged or missing at the time of purchase.  

Alcon Laboratories, Inc.
Fort Worth, TX 76134 USA

See Carton for Directions For Use.  

Country of Origin: USA

LOT:               EXP:

300068258-0824

Label
SYSTANE ULTRA PRESERVATIVE FREE 
polyethylene glycol 400 and propylene glycol solution/ drops
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:0065-1507
Route of AdministrationOPHTHALMIC
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
Polyethylene Glycol 400 (UNII: B697894SGQ) (Polyethylene Glycol 400 - UNII:B697894SGQ) Polyethylene Glycol 4004 mg  in 1 mL
Propylene Glycol (UNII: 6DC9Q167V3) (Propylene Glycol - UNII:6DC9Q167V3) Propylene Glycol3 mg  in 1 mL
Inactive Ingredients
Ingredient NameStrength
Aminomethylpropanol (UNII: LU49E6626Q)  
Boric Acid (UNII: R57ZHV85D4)  
Guaraprolose (3500 Mpa.S At 1%) (UNII: 3A1I7376TC)  
Potassium Chloride (UNII: 660YQ98I10)  
Water (UNII: 059QF0KO0R)  
Sodium Chloride (UNII: 451W47IQ8X)  
Sorbitol (UNII: 506T60A25R)  
Hydrochloric Acid (UNII: QTT17582CB)  
Sodium Hydroxide (UNII: 55X04QC32I)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:0065-1507-821 in 1 CARTON02/15/2022
110 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
2NDC:0065-1507-922 in 1 CARTON04/11/2023
210 mL in 1 BOTTLE, DROPPER; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC Monograph DrugM01802/15/2022
Labeler - Alcon Laboratories, Inc. (008018525)
Establishment
NameAddressID/FEIBusiness Operations
Alcon Research LLC007672236manufacture(0065-1507)
Establishment
NameAddressID/FEIBusiness Operations
Alcon Singapore Manufacturing Pte. Ltd.595170137manufacture(0065-1507)

Revised: 7/2025
Document Id: c459712f-30d9-4084-a6ff-f157d6e604a9
Set id: 751fb85f-6683-4b0a-a650-324d4a74c5de
Version: 5
Effective Time: 20250730
 
Alcon Laboratories, Inc.