PRLR-SLICK CATTLE- prlr gene edit in at least one copy producing protein truncation at or between amino acids 433 to 497 not applicable 
Recombinetics, Inc.

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PRLR-SLICK Cattle

Identity: CRISPR-Cas9 editing with or without homology dependent repair in heat-susceptible beef breeds to introduce mutations into at least one copy of the PRLR gene of Bos taurus chromosome 20 (NC_037347.1). The intended mutations generate a premature stop codon in the coding sequence resulting in a truncated PRLR protein and a SLICK coat phenotype.

Claim: Mutations causing PRLR protein truncation at or between amino acids 433 to 497 produce a SLICK coat phenotype that is reported to be linked to increased thermotolerance in Bos taurus species raised in sub-tropical environments.

Product Use: Founder animals are intended for production and sale of seed stock and/or embryos to enable the establishment of PRLR-SLICK thermotolerant beef herds that will be used as a food source. Due to the specific process used to produce these animals, they may have 2 or more genetically different sets of cells, and as a result the PRLR-SLICK thermotolerant phenotype may not be inherited by all first generation progeny.

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PRLR-SLICK CATTLE 
prlr gene edit in at least one copy producing protein truncation at or between amino acids 433 to 497 not applicable
Product Information
Product TypeItem Code (Source)NDC:86086-006
Route of AdministrationNOT APPLICABLE
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
SLICK ALTERATION DISRUPTING BOS TAURUS G.(NC_037347.1) FS(39099129-39099368) IN EXON 9 OF PRLR GENE IN BOS TAURUS (UNII: B8K52Z76YK) (SLICK ALTERATION DISRUPTING BOS TAURUS G.(NC_037347.1) FS(39099129-39099368) IN EXON 9 OF PRLR GENE IN BOS TAURUS - UNII:B8K52Z76YK) SLICK ALTERATION DISRUPTING BOS TAURUS G.(NC_037347.1) FS(39099129-39099368) IN EXON 9 OF PRLR GENE IN BOS TAURUS1 [arb'U]  in 1 [arb'U]
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:86086-006-011 [arb'U] in 1 NOT APPLICABLE
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
unapproved drug other03/01/2022
Labeler - Recombinetics, Inc. (829874523)
Registrant - Acceligen, Inc. (108237218)
Establishment
NameAddressID/FEIBusiness Operations
Recombinetics, Inc.829874523manufacture

Revised: 7/2024
Document Id: 3f63b2a0-1da1-4136-b5cf-5fcc8039c5ce
Set id: 423a7b9c-9f78-4461-a2de-7e9ee34c12ee
Version: 4
Effective Time: 20240724
 
Recombinetics, Inc.