MATRIX- altrenogest solution
Merck Sharp & Dohme Corp.
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For synchronization of estrus in sexually mature gilts that have had at least one estrous cycle. Treatment with MATRIX® results in estrus (standing heat) 4 to 9 days after completion of the 14-day treatment period.
It is a violation of Federal law to use this drug product other than as directed in the labeling or as directed by your veterinarian.
DESCRIPTION:
MATRIX® (altrenogest) Oral Solution contains 2.2 mg altrenogest per mL (0.22%) in an oil solution.
WITHDRAWAL PERIODS
Animals intended for human consumption must not be slaughtered within 21 days of the last treatment with this drug product.
USER SAFETY WARNINGS:
Not for use in humans. Keep out of reach of children.
Skin contact must be avoided as MATRIX® is readily absorbed through unbroken skin, and exposure may result in serious side effects to both women and men. Always wear vinyl, neoprene, or nitrile protective gloves when handling MATRIX or when in contact with equipment or surfaces contaminated by this product. Latex gloves are not protective.
PREGNANT WOMEN OR WOMEN WHO MAY BE PREGNANT SHOULD NOT HANDLE MATRIX® (altrenogest). WOMEN OF CHILDBEARING AGE SHOULD EXERCISE EXTREME CAUTION WHEN HANDLING THIS PRODUCT.
Accidental absorption, such as absorption through the skin, could lead to a disruption of the menstrual cycle or prolongation of pregnancy. Wash off accidental spillage on the skin immediately with soap and water. Any equipment or surfaces that come in contact with MATRIX® should be adequately cleaned and decontaminated to prevent human exposure.
Always use the MATRIX® Dosing Device to administer this product. The MATRIX® bottle is designed only for use with the MATRIX® Dosing Device. Use without the device increases the risk of human exposure.
PEOPLE WHO SHOULD NOT HANDLE MATRIX®:1
ACCIDENTAL EXPOSURE:
MATRIX® is readily absorbed from contact with the skin. In addition, this oil-based product can penetrate latex or other types of porous gloves. Always wear vinyl, neoprene, or nitrile protective gloves when handling MATRIX®. Latex gloves are not protective. If MATRIX® gets inside gloves by damage or spilling, the covered skin may absorb more of the drug. Side effects after a single exposure are possible; however, continued daily exposure has the potential for more serious effects.
IN CASE OF ACCIDENTAL EXPOSURE:
Skin exposure and/or clothing contamination: Wash skin immediately with soap and water, and launder clothing with detergent.
Eye exposure: Immediately flush with plenty of water for 15 minutes. Get medical attention. If wearing contact lenses, flush eyes immediately with water before removing lenses.
If swallowed: Do not induce vomiting. Seek medical attention immediately. MATRIX® contains an oil. Vomiting should be supervised by a physician because of possible pulmonary damage via aspiration of the oil base. If possible, bring the labeling to the physician.
Reported HUMAN Effects from Exposure:
Side effects have been reported in women and men following accidental exposure to altrenogest products, including MATRIX®, either through handling of the product or contact with contaminated surfaces.
Do not use MATRIX® in gilts having a previous or current history of uterine inflammation (i.e., acute, subacute, or chronic endometritis).
Underdosing of MATRIX® may lead to the occurrence of cystic follicles.
A small percentage (less than 5%) of treated gilts may exhibit estrus (standing heat) during the 14-day treatment period. Gilts nearing estrus at the start of the 14-day treatment period may express estrus early in that period.
While wearing vinyl, neoprene, or nitrile gloves, remove shipping cap and seal; replace with enclosed plastic dispensing cap. This product can penetrate latex or other types of porous gloves. Latex gloves are not protective. Connect the MATRIX® Dosing Device to the solution bottle, according to the instructions provided with the MATRIX® Dosing Device package. Do not use any dosing device other than the MATRIX® Dosing Device.
Administer 6.8 mL (15 mg altrenogest) per gilt once daily for 14 consecutive days. Treat gilts on an individual animal basis by top-dressing MATRIX® on a portion of each gilt's daily feed allowance. To produce the desired synchronization of estrus in a group of gilts, treat all of the gilts daily for the same 14-day period.
MATRIX® (altrenogest) Oral Solution contains 2.2 mg/mL (0.22%) of the active ingredient, packaged in 1,000 mL plastic bottles.
Store MATRIX® solution bottle and Dosing Device when loaded with solution for continued use at or below room temperature, 77°F (25°C). Close tightly. Refer to the MATRIX® Dosing Device label for equipment cleaning instructions. Place empty drug containers, waste from rinsing the Dosing Device, protective gloves, or other articles that contact this product in a leak-resistant container for disposal in accordance with applicable Federal, state, and local regulations.
Approved by FDA under NADA # 141-222
Restricted Drug (California) - use only as directed.
Manufactured for: Intervet Inc.
(d/b/a Merck Animal Health), Rahway,
NJ 07065, a subsidiary of Merck & Co.
Made in France.
Rev. 08/2023
MATRIX®
(altrenogest)
Oral Solution, 2.2 mg altrenogest per mL (0.22%)
FOR USE IN SWINE ONLY
It is a violation of Federal law to use this drug product other
than as directed in the labeling or as directed by your
veterinarian.
MATRIX
altrenogest solution |
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Labeler - Merck Sharp & Dohme Corp. (001317601) |
Establishment | |||
Name | Address | ID/FEI | Business Operations |
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Intervet Production S.A. | 771867553 | LABEL, ANALYSIS, PACK, MANUFACTURE |
Establishment | |||
Name | Address | ID/FEI | Business Operations |
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Aspen Oss b.v. | 491013870 | API MANUFACTURE |
Establishment | |||
Name | Address | ID/FEI | Business Operations |
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Euroapi France | 276495414 | API MANUFACTURE |