REFRESH PLUS- carboxymethylcellulose sodium solution/ drops 
Allergan, Inc.

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REFRESH PLUS® (Preservative-free) 
Drug Facts

Active ingredient

Carboxymethylcellulose sodium 0.5%

Purpose

Eye lubricant

Uses

Warnings

Stop use and ask a doctor if

you experience eye pain, changes in vision, continued redness or irritation of the eye, or if the condition worsens or persists for more than 72 hours.

Keep out of reach of children.

If swallowed, get medical help or contact a Poison Control Center right away.

Directions

To open, TWIST AND PULL TAB TO REMOVE. 

Instill 1 or 2 drops in the affected eye(s) as needed and discard container.

*Follow your eye doctor’s instructions if you are using this product after an eye surgery (e.g., LASIK) to relieve eye dryness and discomfort.

Other information

Inactive ingredients

Calcium chloride dihydrate; magnesium chloride hexahydrate; potassium chloride; purified water; sodium chloride; and sodium lactate. May contain hydrochloric acid and/or sodium hydroxide (to adjust pH).

Questions or comments?

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refreshbrand.com

v1.0DFL0403

PRINCIPAL DISPLAY PANEL

NDC 0023-0403-30
Preservative-free
Refresh
Plus
®
Lubricant Eye Drops
For Eye Dryness
MOISTURIZING RELIEF 
Original Strength
Lubricates & Moisturizes
Recommended for Sensitive Eyes
30 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

NDC 0023-0403-30
Preservative-free
Refresh
Plus®
Lubricant Eye Drops
For Eye Dryness
MOISTURIZING RELIEF 
Original Strength
Lubricates & Moisturizes
Recommended for Sensitive Eyes 
30 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

PRINCIPAL DISPLAY PANEL

NDC 0023-0403-50
VALUE SIZE
50 Vials
Preservative-free
Refresh

Plus®
Lubricant Eye Drops
For Eye Dryness
MOISTURIZING RELIEF
Original Strength
Lubricates & Moisturizes
Recommended for Sensitive Eyes
50 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

NDC 0023-0403-50
VALUE SIZE
50 Vials
Preservative-free
Refresh
Plus®
Lubricant Eye Drops
For Eye Dryness
MOISTURIZING RELIEF 
Original Strength
Lubricates & Moisturizes
Recommended for Sensitive Eyes
50 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

PRINCIPAL DISPLAY PANEL

NDC 0023-0403-70
VALUE SIZE
70 Vials
Preservative-free
Refresh

Plus®
Lubricant Eye Drops
For Eye Dryness
MOISTURIZING RELIEF
Original Strength
Lubricates & Moisturizes
Recommended for Sensitive Eyes
70 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

NDC 0023-0403-70
VALUE SIZE
70 Vials
Preservative-free
Refresh
Plus®
Lubricant Eye Drops
For Eye Dryness
MOISTURIZING RELIEF 
Original Strength
Lubricates & Moisturizes
Recommended for Sensitive Eyes
70 Single-Use Containers
0.01 fl oz (0.4 mL) each Sterile

REFRESH PLUS 
carboxymethylcellulose sodium solution/ drops
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:0023-0403
Route of AdministrationOPHTHALMIC
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
CARBOXYMETHYLCELLULOSE SODIUM (UNII: K679OBS311) (CARBOXYMETHYLCELLULOSE - UNII:05JZI7B19X) CARBOXYMETHYLCELLULOSE SODIUM5 mg  in 1 mL
Inactive Ingredients
Ingredient NameStrength
CALCIUM CHLORIDE (UNII: M4I0D6VV5M)  
MAGNESIUM CHLORIDE (UNII: 02F3473H9O)  
POTASSIUM CHLORIDE (UNII: 660YQ98I10)  
WATER (UNII: 059QF0KO0R)  
SODIUM CHLORIDE (UNII: 451W47IQ8X)  
SODIUM LACTATE (UNII: TU7HW0W0QT)  
HYDROCHLORIC ACID (UNII: QTT17582CB)  
SODIUM HYDROXIDE (UNII: 55X04QC32I)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:0023-0403-055 in 1 CARTON10/09/1996
10.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
2NDC:0023-0403-3030 in 1 CARTON10/09/1996
20.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
3NDC:0023-0403-5050 in 1 CARTON10/09/1996
30.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
4NDC:0023-0403-7070 in 1 CARTON10/09/1996
40.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
5NDC:0023-0403-10100 in 1 CARTON10/09/1996
50.4 mL in 1 VIAL, SINGLE-USE; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC Monograph DrugM01810/09/1996
Labeler - Allergan, Inc. (144796497)

Revised: 6/2022
Document Id: 46382b58-5847-4984-a4d1-b91b832dbe4e
Set id: 0f6a4b4b-cde6-4518-84b5-ce997f1154a7
Version: 11
Effective Time: 20220628
 
Allergan, Inc.