Active ingredients (in each 20 mL)
Acetaminophen 650 mg
Dextromethorphan HBr 20 mg
Triprolidine HCl 2.5 mg
Uses
- temporarily relieves these common cold and flu symptoms:
- headache
- minor aches and pains
- sneezing
- runny nose
- itching of the nose or throat
- cough
- sore throat
- itchy, watery eyes due to hay fever
- temporarily reduces fever
- controls cough to help you get to sleep
Warnings
Liver warning: This product contains acetaminophen. Severe liver damage may occur if you take
- 3 or more alcoholic drinks every day while using this product
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:
- rash
- blisters
- skin reddening
If a skin reaction occurs, stop use and seek medical help right away.
Sore throat warning: If sore throat is severe, persists for more than 2 days, is accompanied or followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
Ask a doctor before use if you have
- cough that occurs with too much phlegm (mucus)
- difficulty in urination due to enlargement of the prostate gland
- liver disease
- a breathing problem such as emphysema or chronic bronchitis
- glaucoma
- persistent or chronic cough such as occurs with smoking, asthma, or emphysema
Ask a doctor or pharmacist before use if you are
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
When using this product
- excitability may occur, especially in children
- alcohol, sedatives, and tranquilizers may increase drowsiness
- marked drowsiness may occur
- use caution when driving a motor vehicle or operating machinery
- avoid alcoholic beverages
Directions
- do not take more than directed
- do not take more than 4 doses in any 24-hour period
- mL = milliliter
- only use the dose cup provided
- adults and children 12 years and over: 20 mL in dosing cup provided every 4 hours
- children under 12 years: do not use
Other information
- store at 25°C (77°F); excursions permitted between 15°-30°C (59°-86°F)
- use by expiration date on package
Inactive ingredients
anhydrous citric acid, FD&C blue #1, FD&C red #40, FD&C yellow #6, flavors, glycerin, propylene glycol, purified water, sodium benzoate, sucralose, xanthan gum
Principal Display Panel
51316-963-45
♥CVS™
NIGHTTIME
COLD & FLU
ACETAMINOPHEN
Pain Reliever, Fever Reducer
Dextromethorphan HBr
Cough Suppressant
Triprolidine HCl, Antihistamine
Compare to Mucinex® Nightshift™
Cold & Flu active ingredients*
Relieves: Fever & sore throat,
Runny nose, Sneezing
Controls Cough
6 FL OZ (177 mL) | Ages 12 & Older
TAMPER EVIDENT: DO NOT USE IF IMPRINTED SAFETY
SEAL UNDER CAP IS BROKEN OR MISSING
PARENTS:
Learn about teen medicine abuse
www.StopMedicineAbuse.org
*This product is not manufactured or
distributed by RB Health (US) LLC,
owner of the registered trademark
Mucinex® Nightshift™ Cold & Flu.
B-063-45 ORG
50844 ORG072406345
Distributed by:
CVS Pharmacy, Inc.
One CVS Drive
Woonsocket, RI 02895
© 2025 CVS/pharmacy
CVS.com®
1-800-SHOP CVS
V-19849
CVS 44-063