3M SOLUPREP S- chlorhexidine gluconate and isopropyl alcohol solution 
Solventum US OpCo LLC

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3M SoluPrep™ S 26mL Brite Green Applicator

Drug Facts

Active ingredients

Chlorhexidine gluconate 2% w/v

Isopropyl alcohol 70% v/v

Purpose

Antiseptic

Antiseptic

Uses

patient preoperative skin preparation:

Warnings

For external use only. Flammable, keep away from fire or flame.

To reduce risk of fire, PREP CAREFULLY:

Allergy Alert: This product may cause a severe allergic reaction. Symptoms may include:

  • wheezing/difficulty breathing
  • shock
  • facial swelling
  • hives
  • rash

If an allergic reaction occurs, stop use and seek medical help right away.

Do not use

  • on patients with known allergies to chlorhexidine gluconate or any other ingredient in this product
  • for lumbar puncture or in contact with the meninges
  • on open skin wounds or as a general skin cleanser

When using this product

  • keep out of eyes, ears, and mouth. May cause serious or permanent injury if permitted to enter and remain. If contact occurs, rinse with cold water right away and contact a doctor.
  • to avoid skin injury, care should be taken when removing drapes, tapes, etc.

Stop use and ask a doctor if irritation, sensitization, or allergic reaction occurs. These may be signs of a serious condition.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions (follow all directions for use)

Getting Patient Ready for Solution:

Activating the Applicator:

When Applying Solution:

After Applying Solution:

While Waiting for Solution to Completely Dry:

After Solution is Completely Dry:

Other information

Inactive ingredients

acetyltri-n-butyl citrate, FD&C blue #1, FD&C yellow #5, purified water USP, Trisodium HEDTA

Questions?

call 1-800-228-3957 (Monday-Friday 7AM-6PM CST). www.3M.com/Medical

34-8727-1905-8

3M SoluPrep™ S 10.5mL Brite Green Applicator

Drug Facts

Active ingredients

Chlorhexidine gluconate 2% w/v

Isopropyl alcohol 70% v/v

Purpose

Antiseptic

Antiseptic

Uses

patient preoperative skin preparation:

Warnings

For external use only. Flammable, keep away from fire or flame.

To reduce risk of fire, PREP CAREFULLY:

Allergy Alert: This product may cause a severe allergic reaction. Symptoms may include:

  • wheezing/difficulty breathing
  • shock
  • facial swelling
  • hives
  • rash

If an allergic reaction occurs, stop use and seek medical help right away.

Do not use

  • on patients with known allergies to chlorhexidine gluconate or any other ingredient in this product
  • for lumbar puncture or in contact with the meninges
  • on open skin wounds or as a general skin cleanser

When using this product

  • keep out of eyes, ears, and mouth. May cause serious or permanent injury if permitted to enter and remain. If contact occurs, rinse with cold water right away and contact a doctor.
  • to avoid skin injury, care should be taken when removing drapes, tapes, etc.

Stop use and ask a doctor if irritation, sensitization, or allergic reaction occurs. These may be signs of a serious condition.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions (follow all directions for use)

Getting Patient Ready for Solution:

Activating the Applicator:

When Applying Solution:

After Applying Solution:

While Waiting for Solution to Completely Dry:

After Solution is Completely Dry:

Other information

Inactive ingredients

acetyltri-n-butyl citrate, FD&C blue #1, FD&C yellow #5, purified water USP, Trisodium HEDTA

Questions?

call 1-800-228-3957 (Monday-Friday 7AM-6PM CST). www.3M.com/Medical

34-8727-1906-6

3M SoluPrep™ S 10.5mL Clear Applicator

Drug Facts

Active ingredients

Chlorhexidine gluconate 2% w/v

Isopropyl alcohol 70% v/v

Purpose

Antiseptic

Antiseptic

Uses

patient preoperative skin preparation:

Warnings

Allergy Alert: This product may cause a severe allergic reaction. Symptoms may include:

  • wheezing/difficulty breathing
  • shock
  • facial swelling
  • hives
  • rash

If an allergic reaction occurs, stop use and seek medical help right away.

Do not use

  • on patients with known allergies to chlorhexidine gluconate or any other ingredient in this product
  • for lumbar puncture or in contact with the meninges
  • on open skin wounds or as a general skin cleanser

When using this product

  • keep out of eyes, ears, and mouth. May cause serious or permanent injury if permitted to enter and remain. If contact occurs, rinse with cold water right away and contact a doctor.
  • to avoid skin injury, care should be taken when removing drapes, tapes, etc.

Stop use and ask a doctor if irritation, sensitization, or allergic reaction occurs. These may be signs of a serious condition.

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions (follow all directions for use)

Getting Patient Ready for Solution:

Activating the Applicator:

When Applying Solution:

After Applying Solution:

While Waiting for Solution to Completely Dry:

After Solution is Completely Dry:

Other information

Inactive ingredients

acetyltri-n-butyl citrate, purified water USP, Trisodium HEDTA

Questions?

call 1-800-228-3957 (Monday-Friday 7AM-6PM CST). www.3M.com/Medical

34-8727-1907-4

Principal Display Panel - 26mL Brite Green Applicator Label

3M

NDC 17518-082-01

STERILE EO

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

REF 67130

for large prep areas below the neck

Sterile Antiseptic Solution

Applicator is sterile if package is intact

Brite Green

0.9 fl oz • 26 mL

Single Use

Only

PRESS CAP DOWN

BACK AND FORTH

APPLICATION

External use only

Professional use only

Read Drug Facts information

before use

34-8727-1931-4

3M and SoluPrep are trademarks of 3M.

Principal Display Panel - 26mL Brite Green Applicator Label

Principal Display Panel - 26mL Brite Green Applicator Insert Label

3M

STERILE EO

NDC 17518-082-01

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

for large prep areas below the neck

Sterile Antiseptic Solution

Applicator is sterile if package is intact

Brite Green

SoluPrep™ S Sterile Antiseptic Solution is a sterile patient preoperative skin preparation.

Each unit dose applicator contains 0.9 fl oz (26 mL) of solution which covers a 13.2 in. x 21.6 in. area (approximate from shoulder to groin in an average full size adult).

For procedures requiring less coverage, a smaller applicator is available (67133 - Tinted or

67134 - Clear). The smaller applicator size contains 0.36 fl oz (10.5 mL) of solution which

covers an approximate 8.4 in. x 15.6 in. area. Do not use more than required for the area.

3M recommends all users participate in product in-service training prior to use.

In-servicing is available on video, from your 3M sales representative or at the 3M website

(www.3m.com).

SoluPrep™ S Sterile Antiseptic Solution is an antimicrobial skin preparation. It is

recommended that the prep remain on the skin after the procedure for continued

protection. The prep will gradually wear away. If however early removal is desired, use

soap and water or 70% isopropyl alcohol.

REF 67130

0.9 fl oz • 26 mL

Made in USA with Globally

Sourced Materials

3M Company

2510 Conway Ave.

St. Paul, MN 55144 USA

1-800-228-3957

www.3M.com/Medical

Single Use Only

3M and SoluPrep are trademarks of 3M.

@ 2022, 3M. All rights reserved.

Not Made With

Natural Rubber Latex

34-8727-1932-2

Principal Display Panel - 26mL Brite Green Applicator Insert Label

Principal Display Panel – 3M SoluPrep™ S 26mL Brite Green Applicator Pouch Label

3M

REF 67130

NDC 17518-082-01

Single

Use Only

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

for large prep areas below the neck

Sterile Antiseptic Solution

Applicator is sterile if package is intact

0.9 fl oz • 26 mL

Brite Green

Principal Display Panel – 3M SoluPrep™ S 26mL Brite Green Applicator Pouch Label

Principal Display Panel – 10.5mL Brite Green Applicator Label

3M

NDC 17518-082-02

STERILE EO

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

REF 67133

for head, neck, and small prep areas

Sterile Antiseptic Solution

Applicator is sterile if package is intact

Brite Green

0.36 fl oz • 10.5 mL

Single Use

Only

3M and

SoluPrep

are trademarks

of 3M.

SNAP

BACK AND FORTH

APPLICATION

External use only

Professional use only

Read Drug Facts information

before use

Principal Display Panel – 10.5mL Brite Green Applicator Label

34-8727-1930-6

Principal Display Panel – 10.5mL Brite Green Applicator Insert Label

3M

STERILE EO

NDC 17518-082-02

SoluPrep™ S

chlorhexidine gluconate

(2% w/v) and isopropyl

alcohol (70% v/v)

Patient Preoperative Skin Preparation

for head, neck, and small prep areas

Sterile Antiseptic Solution

Applicator is sterile if package is intact

Brite Green

SoluPrep™ S Sterile Antiseptic Solution is a sterile

patient preoperative skin preparation. Each unit dose

applicator contains 0.36 fl oz (10.5 mL) of solution which

covers a 8.4 in. x 15.6 in. area.

3M recommends all users participate in product

in-service training prior to use. In-servicing is available

on video, from your 3M sales representative or at the 3M

website (www.3m.com).

SoluPrep™ S Sterile Antiseptic Solution is an

antimicrobial skin preparation. It is recommended that

the prep remain on the skin after the procedure for

continued protection. The prep will gradually wear away.

If however early removal is desired, use soap and water

or 70% isopropyl alcohol.

REF 67133

0.36 fl oz • 10.5 mL

Made in USA with Globally

Sourced Materials

3M Company

2510 Conway Ave.

St. Paul, MN 55144 USA

1-800-228-3957

www.3M.com/Medical

3M and SoluPrep are

trademarks of 3M.

@ 2022, 3M. All rights reserved.

34-8727-1933-0

Principal Display Panel – 10.5mL Brite Green Applicator Insert Label

Principal Display Panel – 3M SoluPrep™ S 10.5mL Brite Green Applicator Pouch Label

3M

REF 67133

NDC 17518-082-02

Single

Use Only

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

for head, neck, and small prep areas

Sterile Antiseptic Solution

Applicator is sterile if package is intact

0.36 fl oz • 10.5 mL

Brite Green

Principal Display Panel – 3M SoluPrep™ S 10.5mL Brite Green Applicator Pouch Label

Principal Display Panel – 10.5 mL Clear Applicator Label

3M

NDC 17518-083-02

STERILE EO

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

REF 67134

for head, neck, and small prep areas

Sterile Antiseptic Solution

Applicator is sterile if package is intact

Clear

0.36 fl oz • 10.5 mL

SNAP

BACK AND FORTH

APPLICATION

External use only

Professional use only

Read Drug Facts information

before use

Single Use

Only

3M and

SoluPrep

are trademarks

of 3M.

34-8727-1929-8

Principal Display Panel – 10.5 mL Clear Applicator Label

Principal Display Panel – 10.5mL Clear Insert Label

3M

STERILE EO

NDC 17518-083-02

SoluPrep™ S

chlorhexidine gluconate

(2% w/v) and isopropyl

alcohol (70% v/v)

Patient Preoperative Skin Preparation

for head, neck, and small prep areas

Sterile Antiseptic Solution

Applicator is sterile if package is intact

Clear

Not Made With

Natural Rubber Latex

Single Use Only

SoluPrep™ S Sterile Antiseptic Solution is a sterile

patient preoperative skin preparation. Each unit dose

applicator contains 0.36 fl oz (10.5 mL) of solution which

covers a 8.4 in. x 15.6 in. area.

3M recommends all users participate in product

in-service training prior to use. In-servicing is available

on video, from your 3M sales representative or at the 3M

website (www.3m.com).

SoluPrep™ S Sterile Antiseptic Solution is an

antimicrobial skin preparation. It is recommended that

the prep remain on the skin after the procedure for

continued protection. The prep will gradually wear away.

If however early removal is desired, use soap and water or 70% isopropyl

alcohol.

REF 67134

0.36 fl oz • 10.5 mL

Made in USA with Globally

Sourced Materials

3M Company

2510 Conway Ave.

St. Paul, MN 55144 USA

1-800-228-3957

www.3M.com/Medical

3M and SoluPrep are trademarks of 3M.

@ 2022, 3M. All rights reserved.

34-8727-1934-8

Principal Display Panel – 10.5mL Clear Insert Label

Principal Display Panel – 3M SoluPrep™ S 10.5mL Clear Applicator Pouch Label

3M

REF 67134

NDC 17518-083-02

Single

Use Only

SoluPrep™ S

chlorhexidine gluconate (2% w/v) and isopropyl alcohol (70% v/v)

Patient Preoperative Skin Preparation

for head, neck, and small prep areas

Sterile Antiseptic Solution

Applicator is sterile if package is intact

0.36 fl oz • 10.5 mL

Clear

Principal Display Panel – 3M SoluPrep™ S 10.5mL Clear Applicator Pouch Label
3M SOLUPREP S 
chlorhexidine gluconate and isopropyl alcohol solution
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:17518-082
Route of AdministrationTOPICAL
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
Chlorhexidine Gluconate (UNII: MOR84MUD8E) (Chlorhexidine - UNII:R4KO0DY52L) Chlorhexidine Gluconate20 mg  in 1 mL
Isopropyl Alcohol (UNII: ND2M416302) (Isopropyl Alcohol - UNII:ND2M416302) Isopropyl Alcohol0.7 mL  in 1 mL
Inactive Ingredients
Ingredient NameStrength
Acetyltributyl Citrate (UNII: 0ZBX0N59RZ)  
FD&C BLUE NO. 1 (UNII: H3R47K3TBD)  
FD&C YELLOW NO. 5 (UNII: I753WB2F1M)  
Water (UNII: 059QF0KO0R)  
Trisodium Hedta (UNII: K3E0U7O8KI)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:17518-082-011 in 1 POUCH01/23/2023
126 mL in 1 APPLICATOR; Type 0: Not a Combination Product
2NDC:17518-082-021 in 1 POUCH01/23/2023
210.5 mL in 1 APPLICATOR; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
NDANDA20828801/23/2023
3M SOLUPREP S 
chlorhexidine gluconate and isopropyl alcohol solution
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:17518-083
Route of AdministrationTOPICAL
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
Chlorhexidine Gluconate (UNII: MOR84MUD8E) (Chlorhexidine - UNII:R4KO0DY52L) Chlorhexidine Gluconate20 mg  in 1 mL
Isopropyl Alcohol (UNII: ND2M416302) (Isopropyl Alcohol - UNII:ND2M416302) Isopropyl Alcohol0.7 mL  in 1 mL
Inactive Ingredients
Ingredient NameStrength
Acetyltributyl Citrate (UNII: 0ZBX0N59RZ)  
Water (UNII: 059QF0KO0R)  
Trisodium Hedta (UNII: K3E0U7O8KI)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:17518-083-021 in 1 POUCH01/23/2023
110.5 mL in 1 APPLICATOR; Type 0: Not a Combination Product
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
NDANDA20828801/23/2023
Labeler - Solventum US OpCo LLC (006173082)
Establishment
NameAddressID/FEIBusiness Operations
3M Company830016148ANALYSIS(17518-082, 17518-083)

Revised: 4/2024
Document Id: 4e149ef4-37e6-46f4-86d7-198f84e64331
Set id: 084aa305-5863-441a-a94d-36bc1b05195a
Version: 3
Effective Time: 20240401
 
Solventum US OpCo LLC