(Read the following instructions carefully before using this medication. If you have any questions, please consult with your doctor).

General Information

Clonidine Transdermal System is a tan colored, oval shaped adhesive PATCH containing an active blood-pressure-lowering medication. It is designed to deliver the drug into the body through the skin smoothly and consistently for one full week. Normal exposure to water, as in showering, bathing, and swimming, should not affect the PATCH.

Figure 1:

The optional white, oval shaped, ADHESIVE COVER should be applied directly over the PATCH, should the PATCH begin to separate from the skin. The ADHESIVE COVER ensures that the PATCH sticks to the skin. The Clonidine Transdermal System PATCH must be replaced with a new one on a fresh skin site if the one in use significantly loosens or falls off.

Skin burns have been reported at the patch site in several patients wearing an aluminized transdermal system during a magnetic resonance imaging scan (MRI). Because the Clonidine Transdermal Patch contains aluminum, it is recommended to remove the system before undergoing an MRI.

How to Apply the Clonidine Transdermal System PATCH

1. Apply the tan colored, oval shaped Clonidine Transdermal System PATCH once a week, preferably at a convenient time on the same day of the week (i.e., prior to bedtime on Tuesday of week one; prior to bedtime on Tuesday of week two, etc.).
   

   Figure 2:

2. Select a hairless area such as on the upper, outer arm or upper chest. The area chosen should be free of cuts, abrasions, irritation, scars or calluses and should not be shaved before applying the Clonidine Transdermal System PATCH. Do not place the Clonidine Transdermal System PATCH on skin folds or under tight undergarments, since premature loosening may occur.
3. Wash hands with soap and water and thoroughly dry them.
4. Clean the area chosen with soap and water. Rinse and wipe dry with a clean, dry tissue.
5. Select the pouch labeled Clonidine Transdermal System and open it as illustrated in Figure 3. Remove the tan colored, oval shaped PATCH from the pouch.
   

   Figure 3:

6. Remove the white translucent plastic protective liner from the PATCH by gently peeling off one half of the liner at a time as shown in Figure 4. Avoid touching the sticky side of the Clonidine Transdermal System PATCH.
   

   Figure 4:

7. Place the Clonidine Transdermal System PATCH on the prepared skin site (sticky side down) by applying firm pressure over the PATCH to ensure good contact with the skin, especially around the edges (Figure 5). Discard the white translucent plastic protective liner and wash your hands with soap and water to remove any drug from your hands.
   

   Figure 5:

8. After one week, remove the old PATCH and discard it (refer to Instructions for Disposal). After choosing a different skin site, repeat instructions 2 through 7 for the application of your next Clonidine Transdermal System PATCH.

What to do if your Clonidine Transdermal System PATCH becomes loose while wearing:

How to Apply the ADHESIVE COVER

Note: The white, oval shaped ADHESIVE COVER does not contain any drug and should not be used alone. The cover should be applied directly over the Clonidine Transdermal System PATCH only if the PATCH begins to separate from the skin, thereby ensuring that it sticks to the skin for seven full days.

1. Wash hands with soap and water and thoroughly dry them.
2. Using a clean, dry tissue, make sure that the area around the oval shaped, tan Clonidine Transdermal System PATCH is clean and dry. Press gently on the Clonidine Transdermal System PATCH to ensure that the edges are in good contact with the skin.
3. Take the white, oval shaped, ADHESIVE COVER (Figure 6) from the plain white pouch and remove the paper liner backing from the cover.
   

   Figure 6:

4. Carefully center the white, oval shaped ADHESIVE COVER over the tan oval shaped, Clonidine Transdermal System PATCH and apply firm pressure, especially around the edges in contact with the skin.

Instructions for Disposal

KEEP OUT OF REACH OF CHILDREN

During or even after use, a PATCH contains active medication which may be harmful to infants and children if accidentally applied or ingested. After use, fold in half with the sticky sides together. Dispose of carefully out of reach of children.

Mfd by: AVEVA
       Drug Delivery Systems, A Nitto Denko Company, Miramar, FL 33025

Mfd for: PAR PHARMACEUTICAL COS, INC., Spring Valley, NY 10977

3001690
PI774-86-1-06
Rev. 11/08