What is the most important information I should know about Metoclopramide?

• the longer you take Metoclopramide and the more Metoclopramide you take. You should not take Metoclopramide for more than 12 weeks.
• if you are older, especially if you are an older woman.
• if you have diabetes.

• lip smacking, chewing, or puckering up your mouth
• frowning or scowling
• sticking out your tongue
• blinking and moving your eyes
• shaking of your arms and legs

• for 4 to 12 weeks to relieve heartburn symptoms with gastroesophageal reflux when certain other treatments do not work.
• to relieve the symptoms of slow stomach emptying in people with diabetes.

• have a history of tardive dyskinesia or have a problem controlling your muscles and movements after taking Metoclopramide or a medicine that works like Metoclopramide.
• have stomach or intestine problems that could get worse with Metoclopramide, such as bleeding, blockage or a tear in the stomach or bowel wall.
• have a type of tumor that can cause high blood pressure such as pheochromocytoma.
• have epilepsy (seizures). Metoclopramide can increase your chance for seizures and make them worse.
• are allergic to metoclopramide. Metoclopramide can cause serious allergic reactions. Stop taking Metoclopramide right away and get emergency help if you have any of these symptoms:
  • swelling of your tongue, throat, lips, eyes or face.
  • trouble swallowing or breathing.
  • skin rash, hives, sores in your mouth, or skin blisters.

• have diabetes. Your dose of insulin may need to be changed.
• had problems controlling your muscle movements after taking any medicine.
• have Parkinson's disease.
• have a type of tumor that can cause high blood pressure (pheochromocytoma).
• have kidney or liver disease.
• have or had depression or mental illness.
• have high blood pressure.
• have heart failure or heart rhythm problems.
• have breast cancer.
• drink alcohol.
• have seizures
• are pregnant or plan to become pregnant. Metoclopramide may harm your unborn baby if taken during the end of pregnancy. Talk to your healthcare provider if you become pregnant while taking Metoclopramide.
• are breastfeeding or plan to breastfeed. Metoclopramide can pass into your breast milk and may harm your baby. You and your healthcare provider should decide if you will take Metoclopramide or breastfeed.

• another medicine that contains metoclopramide, such as REGLAN injection or metoclopramide oral solution
• a medicine for Parkinson's disease
• a blood pressure medicine
• a medicine for depression, especially a Monoamine Oxidase Inhibitor (MAOI)
• an anti-psychotic medicine, used to treat mental illness such as schizophrenia
• insulin
• medicines that can make you sleepy, such as anti-anxiety medicines, sleep medicines, and narcotics If you are not sure if your medicine is one listed above, ask your healthcare provider or pharmacist.

• Take Metoclopramide exactly as your healthcare provider tells you. Do not change your dose unless your healthcare provider tells you to.
• You should not take Metoclopramide for more than 12 weeks.
• Take Metoclopramide at least 30 minutes before each meal and at bedtime.
• If you take too much Metoclopramide, call your poison control center at 1-800-222-1222 or go to the nearest emergency room right away.

• Do not drink alcohol while taking Metoclopramide. Alcohol may make some side effects of Metoclopramide worse, such as feeling sleepy.
• Do not drive, operate machinery, or do other dangerous activities until you know how Metoclopramide affects you.
  Metoclopramide may cause sleepiness or dizziness.

What are the possible side effects of Metoclopramide?

• Tardive dyskinesia (abnormal muscle movements). See " What is the most important information I need to know about Metoclopramide?"
• Other changes in muscle control and movement, such as:
  • Uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia). These muscle spasms can cause abnormal movements and body positions, and speech problems. These spasms usually start within the first 2 days of treatment. Rarely, these muscle spasms may cause trouble breathing. These spasms happen more often in adults less than 30 years of age.
  • Parkinsonism. Symptoms include slight shaking, body stiffness, trouble moving or keeping your balance. If you already have Parkinson's Disease, your symptoms may become worse while you are taking Metoclopramide.
  • Being unable to sit still or feeling you need to move your hands, feet, or body (akathisia). Symptoms can include feeling jittery, anxious, irritated or unable to sleep (insomnia), feeling the need to walk around (pacing) and tapping your feet.

• Neuroleptic Malignant Syndrome (NMS). NMS is a very rare but very serious condition that can happen with Metoclopramide. NMS can cause death and must be treated in a hospital. Symptoms of NMS include: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating.
• Depression, thoughts about suicide, and suicide. Some people who take Metoclopramide become depressed, even if they have no history of depression. You may have thoughts about hurting or killing yourself. Some people who have taken Metoclopramide have ended their own lives (suicide).
• High blood pressure. Metoclopramide can cause your blood pressure to increase.
• Too much body water. People who have certain liver problems or heart failure and take Metoclopramide may hold too much water in their body (fluid retention). Tell your doctor right away if you have sudden weight gain, or swelling of your hands, legs, or feet.
• Increased prolactin. Tell your doctor if your menstrual periods stop, your breasts get larger and make milk, or you cannot have sex (impotence). These symptoms go away when you stop taking Metoclopramide.

• feel depressed or have thoughts about hurting or killing yourself
• have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating
• have muscle movements you cannot stop or control
• have muscle movements that are new or unusual

• restlessness
• drowsiness
• tiredness
• lack of energy

• Store Metoclopramide at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep Metoclopramide in the bottle it comes in and away from light. Keep the bottle closed tightly.