HEAD AND SHOULDERS 2IN1 INSTANT RELIEF- pyrithione zinc lotion/shampoo 
The Procter & Gamble Manufacturing Company

Disclaimer: Most OTC drugs are not reviewed and approved by FDA, however they may be marketed if they comply with applicable regulations and policies. FDA has not evaluated whether this product complies.

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Head and Shoulders ® 2in1

Instant Relief

Drug Facts

Active ingredient

Pyrithione zinc 1%

Purpose

Anti-dandruff

Uses

helps prevent recurrence of flaking and itching associated with dandruff.

Warnings

For external use only.

When using this product

  • avoid contact with eyes. If contact occurs, rinse eyes thoroughly with water.

Stop use and ask a doctor if

  • condition worsens or does not improve after regular use of this product as directed.

Keep this and all drugs out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions

  • for best results use at least twice a week or as directed by a doctor.
  • for maximum dandruff control, use every time you shampoo.
  • shake before use.
  • wet hair, massage onto scalp, rinse, repeat if desired.

Inactive ingredients

Water, sodium laureth sulfate, zinc carbonate,glycol distearate, cocamideMEA, cocamidopropyl betaie, fragrance,dimethicone, sodiumxylenesulfonate,sodium chloride, menthol, guarhydroxypropyltrimonium chloride,sodium benzoate,polyquaternium-10, stearyl alcohol, magnesiumcarbonate hydroxide, cetyl alcohol, mentha piperita(peppermint)oil, mentha arvensis leaf oil, methylchloroisothiazolinone, methylisothiazolinone, yellow5, blue1.

Questions (or comments)?

1-800-723-9569

Dist. by PROCTER & GAMBLE,
CINCINNATI, OH 45202

PRINCIPAL DISPLAY PANEL - 380 mL Bottle Label

head &
shoulders ®

pyrithione zinc dandruff

shampoo + conditioner

INSTANT relief

2in1


cooling scalp relief

INFUSED WITH PEPPERMINT COMPLEX

& TEA TREE ESSENCE

FLAKE FREE.*

UP TO 100%
GUARANTEED^

12.8 FL OZ (380 mL)

HS

HEAD AND SHOULDERS 2IN1  INSTANT RELIEF
pyrithione zinc lotion/shampoo
Product Information
Product TypeHUMAN OTC DRUGItem Code (Source)NDC:37000-342
Route of AdministrationTOPICAL
Active Ingredient/Active Moiety
Ingredient NameBasis of StrengthStrength
PYRITHIONE ZINC (UNII: R953O2RHZ5) (PYRITHIONE ZINC - UNII:R953O2RHZ5) PYRITHIONE ZINC1 g  in 100 mL
Inactive Ingredients
Ingredient NameStrength
BENZYL ALCOHOL (UNII: LKG8494WBH)  
MENTHOL (UNII: L7T10EIP3A)  
MENTHA ARVENSIS LEAF OIL (UNII: 1AEY1M553N)  
METHYLCHLOROISOTHIAZOLINONE (UNII: DEL7T5QRPN)  
METHYLISOTHIAZOLINONE (UNII: 229D0E1QFA)  
FD&C YELLOW NO. 5 (UNII: I753WB2F1M)  
FD&C BLUE NO. 1 (UNII: H3R47K3TBD)  
GUAR HYDROXYPROPYLTRIMONIUM CHLORIDE (1.7 SUBSTITUENTS PER SACCHARIDE) (UNII: B16G315W7A)  
WATER (UNII: 059QF0KO0R)  
SODIUM LAURETH-3 SULFATE (UNII: BPV390UAP0)  
COCO MONOETHANOLAMIDE (UNII: C80684146D)  
ZINC CARBONATE (UNII: EQR32Y7H0M)  
GLYCOL DISTEARATE (UNII: 13W7MDN21W)  
DIMETHICONE (UNII: 92RU3N3Y1O)  
SODIUM XYLENESULFONATE (UNII: G4LZF950UR)  
STEARYL ALCOHOL (UNII: 2KR89I4H1Y)  
PEPPERMINT OIL (UNII: AV092KU4JH)  
SODIUM CHLORIDE (UNII: 451W47IQ8X)  
SODIUM BENZOATE (UNII: OJ245FE5EU)  
MAGNESIUM CARBONATE HYDROXIDE (UNII: YQO029V1L4)  
COCAMIDOPROPYL BETAINE (UNII: 5OCF3O11KX)  
POLYQUATERNIUM-10 (30000 MPA.S AT 2%) (UNII: C7RDC8Y4JS)  
Packaging
#Item CodePackage DescriptionMarketing Start DateMarketing End Date
1NDC:37000-342-5050 mL in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product09/01/201410/13/2018
2NDC:37000-342-38380 mL in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product09/01/201408/14/2022
3NDC:37000-342-66665 mL in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product09/01/201408/20/2022
4NDC:37000-342-9090 mL in 1 BOTTLE, PLASTIC; Type 0: Not a Combination Product12/01/201602/01/2020
Marketing Information
Marketing CategoryApplication Number or Monograph CitationMarketing Start DateMarketing End Date
OTC monograph finalpart358H09/01/201408/20/2022
Labeler - The Procter & Gamble Manufacturing Company (004238200)

Revised: 1/2022
Document Id: d60aa1a6-a76e-7261-e053-2995a90a5f27
Set id: a4662893-4dfa-4e66-9bd3-eb39c9e42e55
Version: 7
Effective Time: 20220120
 
The Procter & Gamble Manufacturing Company