VETone® Saline Solution 0·9% Intravenous Infusion
STERILE NONPYROGENIC SOLUTION
For Animal Use Only
DESCRIPTION
VetOne Saline Solution 0.9% Intravenous Infusion is a sterile, non-pyrogenic solution intended
for water and electrolytes replenishment in single dose containers. May be administered
intravenously using aseptic technique. It contains no antimicrobial agents. Discard any unused
portion. Composition, osmolarity, pH and ionic concentration are shown in Table 1
The container is free of PVC and phthalates. The container meets the requirements of USP and is
registered with US FDA
CLINICAL PHARMACOLOGY
VetOne Saline Solution 0.9% Intravenous Infusion is intended to restore water and electrolytes.
It is capable of inducing diuresis, depending on the clinical condition of the patient.
INDICATIONS AND USAGE
VetOne Saline Solution 0.9% Intravenous Infusion is indicated as a source of water and electrolytes.
WARNINGS
VetOne Saline Solution 0.9% Intravenous Infusion should be used with great care, if at all, in patients
with congestive heart failure, severe renal insufficiency, and in clinical states in which there exists
edema with sodium retention.
The intravenous administration of VetOne Saline Solution 0.9% Intravenous Infusion can cause fluid
and/or solute overloading resulting in dilution of serum electrolyte concentrations, over-hydration,
congested states, or pulmonary edema. The risk of dilutive states is inversely proportional to the
electrolyte concentration of the injections. The risk of solute overload causing congested states with
peripheral and pulmonary edema is directly proportional to the electrolyte concentrations of the injections.
In patients with diminished renal function, administration of VetOne Saline Solution 0.9% Intravenous
Infusion may result in sodium retention.
ADVERSE REACTIONS
Reactions which may occur because of the solution or the technique of administration include febrile
response, infection at the site of injection, venous thrombosis or phlebitis extending from the site of
injection, extravasation, and hypervolemia.
If an adverse reaction does occur, discontinue the infusion, evaluate the patient, institute appropriate
therapeutic countermeasures and save the remainder of the fluid for examination if deemed necessary.
PRECAUTIONS
Clinical evaluation and periodic laboratory determinations are necessary to monitor changes in fluid
balance, electrolyte concentrations, and acid base balance during prolonged parenteral therapy or
whenever the condition of the patient warrants such evaluation·
Caution must be exercised in the administration of VetOne Saline Solution 0.9% Intravenous
Infusion to patients receiving corticosteroids or corticotrophin.
Do not administer unless solution is clear and seal is intact.
DOSAGE AND ADMINISTRATION
As directed by a veterinarian. Dosage is dependent upon the age, weight and clinical condition of the
patient, as well as laboratory determinations.
Parenteral drug products should be inspected visually for particulate matter and discolouration prior
to administration whenever solution and container permit.
All injections in plastic containers are intended for intravenous administration using sterile equipment.
Additives may be incompatible. Complete information is not available. Those additives known to be
incompatible should not be used Consult with pharmacist, if available. If, in the informed judgement
of the veterinarian, it is deemed advisable to introduce additives, use aseptic technique. Mix thoroughly
when additives have been introduced. Do not store solutions containing additives.
OVERDOSAGE
In an event of over-hydration or solute overload, re-evaluate the patient and institute appropriate
corrective measures. See Warnings, Precautions and Adverse Events.
PACKS SUPPLIED
VetOne Saline Solution 0.9% Intravenous Infusion in plastic container is available as follows:
Exposure of pharmaceutical products to heat should be minimized· Avoid excessive heat. It is
recommended the product be stored at room temperature (86°F/30°C). Protect from freezing·
DIRECTIONS FOR USE OF PLASTIC CONTAINER
To Open
Tear overwrap at silt and remove solution container. Some opacity of the plastic due to moisture absorption
during the sterilization process may be observed. This is normal and does not affect the solution quality or
safety. The opacity will diminish gradually. Check for minute leaks by squeezing solution container firmly.
If leaks are found, discard solution as sterility may be impaired. If supplemental medication is desired,
follow directions below:
Preparation for Administration
1. Suspend container from eyelet support.
2. Remove plastic protector from inlet/outlet port at bottom of container.
3. Attach administration set.
To Add Medication
WARNING: Additives may be incompatible.
To add medication before solution administration
1·Prepare medication site.
2·Using syringe with 0.63mm to 0.80mm need puncture medication port and inject.
3·Mix solution and medication thoroughly. For high density medication such as potassium chloride,
squeeze ports while ports are upright and mixthoroughly.
To add medication during solution administration
1. Close the clamp on the administration set.
2. Prepare medication site.
3. Using syringe with 0.63mm to 0.80mm needle, puncture medication port and inject.
4. Remove container from IV pole and/or turn to an upright position.
5. Evacuate both ports by squeezing them while container is in the upright position.
6. Mix solution and medication thoroughly.
7. Return container to in use position and continue administration.
