DEXAMETHASONE SOLUTION - dexamethasone solution
MWI/VetOne
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CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian.
Experimental animal studies on dexamethasone have revealed it possesses greater anti-inflammatory activity than many steroids. Veterinary clinical evidence indicates dexamethasone has approximately 20 times the anti-inflammatory activity as prednisolone and 70 to 80 times that of hydrocortisone. Thymus involution studies show dexamethasone possesses 25 times the activity of prednisolone. In reference to mineralcorticoid activity, dexamethasone does not cause significant sodium or water retention. Metabolic balance studies show that animals on controlled and limited protein intake will exhibit nitrogen losses on exceedingly high dosages.
Dexamethasone is indicated for the treatment of primary bovine ketosis and as an anti-inflammatory agent in the bovine and equine.
As supportive therapy, Dexamethasone may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids. Dexamethasone may be used intravenously as supportive therapy when an immediate hormonal response is required.
Bovine Ketosis
Dexamethasone is offered for the treatment of primary ketosis. The gluconeogenic effects of Dexamethasone, when administered intramuscularly, are generally noted within the first 6 to 12 hours. When Dexamethasone is used intravenously, the effects may be noted sooner. Blood sugar levels rise to normal levels within 12 to 24 hours. Acetone bodies are reduced to normal concentrations usually within 24 hours. The physical attitude of animals and appetite improves, usually within 12 hours. Milk production, which is suppressed as a compensatory reaction in this condition, begins to increase. In some instances, it may even surpass previous peaks. The recovery process usually takes from 3 to 7 days.
Supportive Therapy
Dexamethasone may be used a supportive therapy in mastitis, metritis, traumatic gastritis, and pyelonephritis, while appropriate primary therapy is administered. In these cases, the corticosteroid combats accompanying stress and enhances the feeling of general well-being.
Dexamethasone may also be used as supportive therapy in inflammatory conditions such as arthritic conditions, snake bite, acute mastitis, shipping fever, pneumonia, laminitis, and retained placenta.
Equine
Dexamethasone is indicated for the treatment of acute musculoskeletal inflammations, such as bursitis, carpitis, osselets, tendonitis, myositis, and sprains. If boney changes exist in any of these conditions, joints, or accessory structures, a response to Dexamethasone cannot be expected. In addition, Dexamethasone may be used as supportive therapy in fatigue, heat exhaustion, influenza, laminitis, and retained placenta provided that the primary cause is determined and corrected..
Therapy with Dexamethasone, as with any other potent corticosteroid, should be individualized accordingly to the severity of the condition being treated, anticipated duration of steroid therapy, and animal's threshold or tolerance for steroid excess. Treatment may be changed over to Dexamethasone from any other glucocorticoid with proper reduction or adjustment of dosage.
Bovine: Dexamethasone: 5-20mg intravenously or intramuscularly.
Equine: Dexamethasone: 2.5-5mg intravenously or intramuscularly.Except for emergency therapy, do not use in animals with chronic nephritis and hyper-corticalism (Cushing's Syndrome). Existence of congestive heart failure, diabetes, and osteoporosis are relative contraindications. Do not use in viral infections during the viremic stage.
NDC 13985-037-02
100mL
VetOne
Dexamethasone Solution
Sterile Vial (2mg/mL)
CAUTION: Federal law restricts this drug to use by or on the order of a licensed veterinarian
FOR ANIMAL USE ONLY
KEEP OUT OF REACH OF CHILDREN
ANADA # 200-312, Approved by FDA
Net Contents: 100mL
DEXAMETHASONE SOLUTION
dexamethasone solution |
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Labeler - MWI/VetOne (019926120) |