EAZI-BREED CIDR  SHEEP - progesterone insert, extended release 
Pharmacia & Upjohn

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EAZI-BREED™
CIDR®
(progesterone)

Sheep Insert

Active Ingredient

Progesterone, 0.3 gram per EAZI-BREED CIDR Sheep Insert

Use

Induction of estrus in ewes (sheep) during seasonal anestrus. Seasonal anestrus is when ewes do not have regular estrous cycles outside the natural breeding season. EAZI-BREED CIDR Sheep Inserts have not been tested in estrous cycling ewes.

Read booklet label before using drug for complete product information.

WARNINGS

Human Warning

Avoid contact with skin by wearing protective gloves when handling the inserts.

Keep this and all medications out of the reach of children.

Environmental Warning

Used (removed) EAZI-BREED CIDR Sheep Inserts still contain some progesterone. Used EAZI-BREED CIDR Sheep Inserts must be stored in a sealable container until disposed. Sealed bag/container with used EAZI-BREED CIDR Sheep Inserts must be properly disposed in accordance with applicable local, state and Federal regulations.

Residue Warning

A pre-slaughter withdrawal period is not required when this product is used according to label directions.

Other Information

Store at controlled room temperature 20° to 25° C (68° to 77° F) with excursions between 15° to 30° C (59° to 86° F).

To report suspected adverse reactions or questions call Pfizer Animal Health at 1-800-366-5288.

Inactive Ingredients

silicone rubber, nylon.

DO NOT USE

• in ewes with abnormal, immature or infected genital tracts
• in ewes that have never lambed
• an insert more than once. To prevent the potential transmission of venereal and blood borne diseases the EAZI-BREED CIDR Sheep Insert should be disposed after a single use.

WHEN USING THIS PRODUCT

• In ewes that respond to treatment the onset of estrus generally occurs within 1 to 3 days after removal of the EAZI-BREED CIDR Sheep Insert.
• Make sure to have a sufficient number of rams to adequately breed all ewes with an induced estrus. Breeds of rams may vary in libido in the non-breeding season. Therefore a ewe to ram ratio up to 18:1 is recommended for multi-sire situations. For single sire lots, 12:1 for ram lambs and up to 18:1 for yearling rams are recommended.

YOU MAY NOTICE

Clear, cloudy, yellow or bloody mucus on the outside of EAZI-BREED CIDR Sheep Insert when removed from ewes. The mucus may have an offensive odor. This is a result of mild irritation to the vaginal lining by the presence of the EAZI-BREED CIDR Sheep Insert, and generally clears between the time of removal and breeding. Such irritation does not affect fertility.

DIRECTIONS

For induction of estrus in ewes (sheep) during seasonal anestrus:

• Administer one EAZI-BREED CIDR Sheep Insert per ewe for 5 days.
• After insert removal, use standard flock breeding procedures to breed ewes at induced estrus.

Insertion

1. Avoid contact with skin by wearing protective gloves when handling inserts.
2. Only use the specially designed EAZI-BREED CIDR Sheep Insert Applicator for administration.
3. Restrain ewes appropriately prior to administration.
4. Wash the applicator in a non-irritating antiseptic solution, and then apply a veterinary obstetrical lubricant to the end of the applicator.
5. Push the tail end of the EAZI-BREED CIDR Sheep Insert into the applicator taking care to assure the tail is extending upward through the slot of the applicator and is pointed away from the handle.
6. Fold the wings of the EAZI-BREED CIDR Sheep Insert to make it longer and continue to advance the insert into the applicator until it is fully seated with only the tips of the wings protruding from the end of the applicator (see Figure 1).
7. Lubricate the protruding tips of the wings of the EAZI-BREED CIDR Sheep Insert with veterinary obstetrical lubricant.
8. Clean the exterior of the vulva with disposable tissue.
9. Open the lips of the vulva and gently place the loaded applicator through the vulva. The slot in the applicator should face down (see Figure 2).
10. Once the loaded applicator is past the vulva slope the applicator slightly upwards (35 - 45° angle) by lowering the handle, and then forward, without forcing, until the applicator is fully inserted or resistance is felt (see Figure 3).
11. Squeeze the finger grips within the handle of the applicator to deposit the EAZI-BREED CIDR Sheep Insert in the anterior vagina (see Figure 4) and then pull the applicator backwards to remove it from the vagina.
12. With the EAZI-BREED CIDR Sheep Insert correctly placed, with the wings open in the anterior portion of the vagina, the tail of the insert should be visible, pointing downward from the vulva of the ewe.

Figure 1	Figure 2
Figure 3
Figure 4

Removal

1. Remove EAZI-BREED CIDR Sheep Inserts by pulling, gently but firmly, on the protruding nylon tail.
2. EAZI-BREED CIDR Sheep Inserts may reverse direction within the vagina; therefore, if the nylon tail of the insert is not visible on the day of removal, check the vagina to determine if an insert is present.
3. Used (removed) EAZI-BREED CIDR Sheep Inserts must be stored in a sealable container until disposed. Sealed bag/container with used EAZI-BREED CIDR Sheep Inserts must be properly disposed in accordance with applicable local, state and Federal regulations.

Made in New Zealand

EAZI-BREED is a trademark and CIDR is a registered trademark of DEC International, NZ, Ltd.

1533000
10417300
39020416-04/09

PRINCIPAL DISPLAY PANEL

EAZI-BREED™
CIDR®
(progesterone)
Sheep Insert

NET CONTENTS: 20 EAZI-BREED CIDR Sheep Inserts per bag
Each EAZI-BREED CIDR Sheep Insert contains 0.3 gram of
progesterone in molded silicone over a flexible nylon spine.
Attached to each EAZI-BREED CIDR Sheep Insert is a nylon tail.

NADA 141-302, Approved by FDA

EAZI-BREED CIDR   SHEEP progesterone   insert, extended release

Product Information Product Type OTC ANIMAL DRUG NDC Product Code (Source) 0009-1533 Route of Administration VAGINAL DEA Schedule

Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength progesterone (progesterone) progesterone 0.3 g

Inactive Ingredients Ingredient Name Strength No Inactive Ingredients Found

Product Characteristics Color      Score      Shape Size Flavor Imprint Code Contains

Packaging # NDC Package Description Multilevel Packaging 1 0009-1533-01 20 INSERT In 1 BAG None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
NADA	NADA141302	10/01/2009

Labeler - Pharmacia & Upjohn (829076566)

Registrant - Pfizer Inc (001326495)

Establishment
Name	Address	ID/FEI	Operations
DEC International (NZ) Limited		595014127	MANUFACTURE

Revised: 11/2009Pharmacia & Upjohn